CIHR Projects
Browse 4616 CIHR-funded research projects
Search & Filter Projects
Showing 51-100 of 4616 projects
A healthy brain requires a healthy body. It is increasingly recognized that by improving the general metabolism of the body, one can improve brain function. This may be particularly true for Alzheime…
L'autisme est une condition qui se traduit par des difficultés dans les interactions sociales. Les personnes autistes ont plus de problèmes de santé et utilisent davantage les services de santé que l…
PI: Sargin, Derya
We live in a world profoundly shaped by social behaviours involving interactions and communications between the members of a given species. All mammals, ranging from primates to rodents, depend on ea…
PI: Topolnik, Lisa Y
Dendrites, the tree-like neuronal extensions, receive and analyze information from thousands of synaptic inputs and consume most of the brain energy. Activation of a single synapse on a dendrite may …
PI: Moayedi, Massieh
Endocannabionoids are molecules produced in the body that bind to cannabinoid receptors. These molecules have some of the same properties as cannabis products. There is a lot of evidence from animal …
PI: Martinez-Trujillo, Julio C
Spatial navigation involves the formation of cognitive maps of the environment containing spatial relationships between objects. Past studies have shown that the mammalian brain possesses an instanti…
PI: Verge, Valerie M; Chan, Kam M
Peripheral nerve injuries are common and often associated with poor outcomes including incomplete repair, debilitating pain states and compromised function - a reality we aim to change. We can greatl…
PI: Chen, Hsiao-Huei
Autism Spectrum of Disorders (ASD) affect young children and last a lifetime. Mutations in >100 genes cause ASD, and this has made finding therapies a challenge. Many people with ASD respond poorly t…
PI: Sapieha, Przemyslaw (Mike) S
Age-related macular degeneration (AMD) is a multifactorial neuroinflammatory disease of the aging eye precipitated by genetic and environmental risk factors. It is the leading cause of irreversible b…
PI: Tiberi, Mario
Dopamine is an important chemical of the brain. Dopamine communicates with the exterior of nerve cells by attaching to specialized group of proteins called D1, D2, D3, D4 and D5 receptors to unlock s…
Universal Activation Mechanisms in Class A GPCRs - Inspiration for next generation drug discovery
The G Protein-Coupled Receptor (GPCR) superfamily consists of over 830 distinct 7-transmembrane proteins, governing sensory and neuronal signalling, cell homeostasis, and immune response. As one thir…
PI: Best, Michael W; Bowie, Christopher R; Doell, Faye K; Foussias, George; Grossman, Michael; Kidd, Sean A; Menon, Mahesh; Wang, Wei; Woodward, Todd S
Cognitive behavioural therapy (CBT) is a psychological intervention designed to specifically target the positive and negative symptoms of schizophrenia-spectrum disorders with the ultimate goal of im…
We live in a 24-hour world where our daily activities are organized around the day-night cycle. Many of us wake up, eat our meals, go to work, and sleep at approximately the same time every day. Our …
Neurons that use the chemical dopamine as a neurotransmitter have as a distinguishing characteristic a very long and elaborate axon with multiple branches and neurotransmitter release sites. Our rece…
PI: Steve, Trevor T; Camicioli, J. Richard M
Dementia is an emerging public health crisis, with 150 million people predicted to develop dementia worldwide by 2050. In Canada, dementia is predicted to affect approximately 3% of the population by…
PI: Bonizzato, Marco
We are establishing a novel technology to recover movement after spinal cord injury. Unmet need: Cervical spinal cord injury (SCI) causes tetraplegia, a paralysis of the four limbs. The number one pr…
PI: Peever, John H
Persistent daytime sleepiness - or the inability to maintain alert wakefulness - is a major public health concern because it impairs a person's quality of life, leaving them physically, mentally and …
One third of patients with major depressive disorder (MDD) do not respond to conventional treatments and experience treatment-resistant depression (TRD). There has been a resurgence of interest on th…
PI: Kerr, Bradley
Neuropathic pain (NP) is typically described as 'the worst pain imaginable' on patient rating scales. It is currently incurable, arising in response to injuries or diseases that directly affect the n…
PI: Frampton, John P
The cornea is a thin transparent tissue that protects the internal parts of the eye and refracts light onto the retina. Severe corneal damage can lead to irreversible scarring that prevents light fro…
PI: Winston, Gavin P; Omisade, Antonina
One in 10 people have a seizure during their life. Usually no cause is identified. Seizures without an identified cause are called unprovoked first seizure (UFS). Most of these people do not have fur…
PI: Bayley, Mark T; Eng, Janice J
A stroke happens when blood flow to the brain is stopped and the brain gets damaged. At least half of people with a stroke have fatigue months and even years later. A lot of people report fatigue as …
While there is strong evidence supporting the role of the anterior cingulate cortex, basolateral amygdala, and the hippocampus (ACC, BLA, HIPP) as a key neural network regulating mood, and therefore …
PI: Boyd, Lara
Stroke in Canada has become a chronic disease; over 80% of Canadians who have a stroke will survive but rehabilitation approaches have fallen short of the goal of restoring function. The net result i…
PI: Timofeev, Igor; Fecteau, Shirley
Brain trauma triggers epileptogenesis, which after several weeks or month leads to epilepsy. Known mechanisms are following: Brain trauma leads to neuronal loss, and therefore local decrease in excit…
PI: Cook, Douglas J
After a mild traumatic brain injury (mTBI), or concussion, patients can suffer with symptoms such as nausea, headache, fatigue, and other changes that affect their quality of life. Changes in the bra…
PI: Nagy, Corina
One in 5 Canadians and almost 350 million people worldwide suffer from major depressive disorder (MDD). Depression has devastating consequences on human health, affecting all facets of life. Though t…
PI: Hampson, David R
Dravet Syndrome (DS) is a devastating and sometimes fatal neurodevelopmental disorder. Its symptoms include severe epilepsy as well as neurological and developmental disorders. Roughly 80% of affecte…
Susceptibility weighted imaging is an magnetic resonance imaging (MRI) scan widely used in routine brain exams. The scan combines magnitude (which corresponds to the brightness of a lighthouse beam) …
PI: Craig, Ann Marie
Current estimates suggest over 1 in 50 people in Canada are living with autism or schizophrenia, neuropsychiatric disorders with a strong genetic component. Disruptions in one copy of a gene called N…
PI: Markoulakis, Roula; Kodeeswaran, Sugy; Levitt, Anthony J
Youth with mental health and/or addictions (MHA) concerns often fall through gaps in care settings and systems, which can negatively impact their long-term outcomes. Many youth may also have family m…
PI: Hatcher, Simon
For people experiencing homelessness, accessing healthcare poses significant barriers including a lack of proof of insurance, access to transportation as well as institutionalized stigma. People who …
PI: Levitt, Sarah E; Buchman, Daniel
Palliative psychiatry is an approach centered on the quality-of-life concerns of patients and their families in circumstances of severe and persistent mental illness (SPMI) where there is a likelihoo…
PI: Dimitropoulos, Gina; MacEachern, Shauna; Couturier, Jennifer L; Hutt-MacLeod, Daphne; Kimber, Melissa S; Moore, Kerrie; Mushquash, Christopher J; Norman, Lia G; Perri, Andrea; Sauerwein, Jessica L; Webb, Cheryl
Eating disorders (EDs) are serious mental illnesses associated with significant mortality and medical complications. Their peak onset is in adolescence and early adulthood; this is also the time of t…
PI: Bethell, Jennifer M; Mclaurin, Joanne
Patient engagement in research is where individuals with personal experience of a health issue and caregivers (e.g., family and friends) get involved in the research process - not as study subjects, …
PI: Murata, Lisa
Due to a clinical need for improved treatments for psychosis including delusions and paranoia, The Feeling Safe Programme was recently developed by a team at University of Oxford. The aim was to deve…
PI: Durbin, Janet; Langill, Gordon; Selick, Avra
There is a well-established gap in efforts to transfer evidence-based treatments into routine delivery with quality in community settings. This is a particular challenge in the mental health system w…
PI: Sikstrom, Laura
The COVID-19 pandemic catalyzed a rapid transition to virtual care across Canada. However, research indicates that health care providers often felt under-prepared to make the transition to virtual pr…
PI: Galea, Liisa A
The meeting will explore how hormonal contraceptives influence girl's and women's brain health. Hormonal contraceptives are used by 850M girls and women worldwide and 16% of people (5-49y) in Canada.…
Il devient de plus en plus évident que dans les conditions de financement actuelles, en Europe comme en Amérique du Nord, la création de réseaux de collaborateurs concentrant leurs expertises complém…
PI: Polillo, Alexia; Bromley, Sarah J; Durbin, Janet; Kozloff, Nicole
Early psychosis intervention (EPI) is a comprehensive and life-saving treatment for youth with psychosis. Ontario is considered a leader in the development and delivery of EPI services, with the Mini…
PI: Vallières, Luc
The sixteenth congress of the International Society of Neuroimmunology (ISNI) will take place at the Quebec City Convention Center in August 2023. Nearly 1000 participants are expected. It will be ch…
PI: Henry, Melissa
Medical Assistance in Dying (MAiD) is legal in Canada since 2016. Many eligibility criteria are challenging to assess, especially unbearable suffering and providing informed consent (i.e., providing …
PI: Stergiopoulos, Vicky; Tajirian, Tania
Individuals suffering from severe mental illness (e.g., depression, schizophrenia) are less likely to receive equitable access and care for their physical health needs. Given that this population are…
While stress is essential for survival and adaptation, intense or unrelenting stress particularly when experienced during development can have long-lasting negative effects. Indeed, stress experience…
A meeting of researchers, rehabilitation professionals, lived experts and the MS Society of Canada staff to potentially build a new national research platform to accelerate the development and testin…
PI: Smart, Colette M; McVaugh-Smock, Simon
About 9.2% of the Canadian population has post-traumatic stress disorder (PTSD). Persons dealing with a major medical event such as a brain injury or stroke may be at even higher risk for experiencin…
PI: Gopaul, Urvashy
Background: Stroke is a leading cause of disability in Canada, with 85% of stroke survivors experiencing at least some movement, sensory and cognitive deficits. It is essential to maximize interactio…
PI: Rezaei, Edris
Alzheimer disease (AD) is a progressive neurodegenerative disease characterized by neurofibrillary amyloid plaques and hyperphosphorylated tau tangles that result in cognitive impairment, sleep distu…
PI: Everling, Stefan
Deficits in cognition such as attention and response suppression are a characteristic feature of many neurological and psychiatric disorders. These cognitive deficits can easily be tested with simple…