CIHR Projects
Browse 1999 CIHR-funded research projects
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Showing 51-100 of 1999 projects
PI: Jones, Nicola L; Bhat, Mamatha; Hirota, Simon A; Kaplan, Gilaad G; Lee, Kate; McKay, Derek M; Otley, Anthony R; Pena-Sanchez, Juan-Nicolas; Perreault, Nathalie; Reynolds, Lisa A; Rose, Christopher; Targownik, Laura E; Vallance, Bruce A; Verdu, Elena F
A healthy gut is key to good health and wellbeing. However, changes within our bowel and the bacteria housed in our gut can lead to diseases in our intestine such as inflammatory bowel disease, or ir…
PI: Tchernof, André; Ball, Geoff D; Blondin, Denis; Brunt, Keith R; Colquhoun, Heather; Doucette, Christine A; Forhan, Mary A; McGavock, Jonathan M; Parry, Monica J; Screaton, Robert A; Sénéchal, Martin; Wei, Xiaolin; Wing, Simon S
Canada is fortunate to have many highly productive research teams, networks and institutions, tackling a range of research gaps in the prevention and treatment of diabetes, obesity and cardiometaboli…
High intake of sugar-sweetened pop has been linked with excess weight gain and an increased risk for type 2 diabetes and heart disease. Because of this, health experts have recommended that people re…
Nutrition plays an important role in preventing heart disease and stroke, but current diet advice is not being used well to lower the number of heart attacks or strokes. Delivery of diet advice can b…
PI: Wong, Helen
Healthy diets are important for the prevention of chronic diseases and the maintenance of health. Retail food environments, like grocery stores, can shape the types of food that we buy and eat. Our f…
PI: Ghasemian Moghaddam, Mohammadamir
In the pancreas, alpha-cells release glucagon (which causes blood sugar to go up) and beta-cells release insulin (which causes blood sugar to go down); and for the control of blood sugar, secretion o…
PI: Olstad, Dana Lee; Lee, Joon
Background: Unhealthy food marketing has a negative impact on what children eat and on their health. Health Canada is going to ban digital marketing of unhealthy food that appeals to children <13 yea…
High blood potassium is very frequent in people receiving hemodialysis treatment, with one blood test out of every five revealing life-threatening high potassium levels. Dietary restriction of natura…
PI: Isenring, Paul
NKCC2 operates with other transporters in the kidney to reabsorb or excrete salt and water in appropriate quantities. Importantly, high blood pressure (or hypertension) is known to develop when the k…
Our vision is to establish a complete understanding of the biology of human beta cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabet…
PI: Advani, Andrew
Kidney disease is one of the most devastating complications of diabetes. We urgently need new treatments. Sometimes kidney disease in diabetes develops gradually over years. This is called chronic ki…
Healthy eating during pregnancy has favorable effects on markers related to diabetes (glucose tolerance) and is associated with lower gestational diabetes mellitus (GDM) risk. The cornerstone of GDM …
PI: Chan, John S
Diabetes and high blood pressure are major risk factors in the development of heart disease, including stroke, heart attacks and kidney failure. Keeping blood sugar at normal levels with insulin and …
PI: Marette, André
Obesity and type 2 diabetes (T2D) are chronic diseases that affect millions of people worldwide. A variety of diets have been proposed to offset obesity and T2D but the focus has been mainly to reduc…
PI: Baxter, Jo-Anna
Malnutrition is an underlying cause of millions of maternal and infant deaths, especially in resource-limited settings where food may be inadequate in quantity and/or quality. As breastmilk is consid…
People with obesity and type 2 diabetes have a much greater risk of developing liver fibrosis, the formation of scar tissue in the liver. Due to the rising rates of obesity and type 2 diabetes in Can…
Common complications during pregnancy include diabetes, high blood pressure, preterm birth. These are worrisome as they are linked to higher rates of diseases in later life for both the mother and th…
Obesity is a growing global health concern and is a major risk factor for type 2 diabetes (T2D). Although there is large evidence demonstrating an obesity-T2D relationship, the underlying mechanism i…
PI: Tabatabaei Dakhili, Seyed Amirhossein
It is now estimated that one-third of Canadians are living with diabetes or prediabetes and approximately 90% of these individuals are diagnosed with type 2 diabetes (T2D), the vast majority of which…
1 in 12 Canadians is suffering from rare genetic disorder and every 30 minute a child is born with mutations affecting mitochondrial function. Mitochondria are little "factories" in our cells needed …
PI: Hur, Woo suk
Non-alcoholic fatty liver disease is a growing health problem that affects over 8 million Canadians. Patients with fatty liver disease are more likely to experience liver failure, stroke and heart di…
Autophagy is a cellular degradation process in which different resident and foreign unwanted intracellular components are digested. Autophagy is activated by different cellular stresses such as starv…
PI: Rai, Sharan
Gout is the most common inflammatory arthritis among Canadians and is associated with increased risks of other metabolic diseases and premature death. Gout is caused by hyperuricemia, which refers to…
PI: Simard, MĂ©lissa
Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue. If not resolved, acute inflammation can result in organ pathologies leading to chronic in…
PI: Woo, Minna N; Cheung, Angela M; Gouspillou, Gilles; Grol, Matthew W; Kapoor, Mohit
Diabetes and osteoarthritis (OA) are two of the most common diseases affecting approximately 11 million and 4 million Canadians, respectively. Diabetes is associated with several serious complication…
PI: Wicklow, Brandy A; Dart, Allison B; Doucette, Christine A; Jones, Meaghan J; Lynn, Francis C
T2D in childhood continues to increase worldwide and affects Indigenous children and families more than non-Indigenous populations. Childhood onset T2D is associated with high rates of early onset ra…
PI: Dubé, Marie-Pierre; Carpentier, André C; Lewis, Gary F; Tardif, Jean-Claude
Colchicine is an anti-inflammatory medication and is one of the oldest remedies still commonly in use today as a treatment for gout. Recently, we have led the COLCOT study, showing that colchicine re…
PI: Cherney, David Z; Campbell, David J; Layton, Anita; Perkins, Bruce A
Diabetes is the most common cause of kidney failure in Canada, and requires either dialysis or a kidney transplant. Kidney failure leads to persistent unpleasant symptoms that reduce quality of life …
PI: Verchere, Bruce C; Hosak, Ramya; Klein Geltink, Ramon; Levings, Megan K; Santamaria, Pere; Tsai, Sue Y
Type 1 diabetes (T1D) is an autoimmune disease that occurs when the immune system mistakenly kills the beta cells in the pancreas that produce the hormone, insulin. A true cure for T1D requires the i…
PI: Kieffer, Timothy J; Hoesli, Corinne; Rideout, Elizabeth J; Shakiba, Nika
Diabetes is a debilitating disorder of high blood sugar that afflicts millions of Canadians. People living with type 1 diabetes lack the cells that release the hormone insulin, so multiple daily insu…
PI: Shapiro, James; Kieffer, Timothy J; Korbutt, Gregory S; MacDonald, Patrick E; Pepper, Andrew R
Diabetes is caused by the lack of insulin, a hormone produced by the islet Beta-cells in the pancreas that regulates blood sugar. Chronically high blood sugar can cause complications such as blindnes…
PI: MacDonald, Patrick E; Bruin, Jennifer E; Johnson, James D; Xia, Jianguo
Insulin is secreted from cells of the pancreatic islets of Langerhans into the blood after a meal to control blood sugar levels. In type 1 diabetes (T1D) islet cells are destroyed by an auto-immune r…
Overgrowth syndromes consist of a group of diseases characterized by excessive growth of certain parts of the body and a variety of anatomical deformities. As an example, Joseph Merrick (1862-1890), …
PI: Marette, André
Changes in the type of gut microbes (known of the microbiota) can promote obesity and diabetes. We showed that type 2 diabetes alters bacteria in adipose tissues and the liver in obese persons and we…
PI: Pai, Nikhil
This study will assess the effects of using a simple, low-cost, safe dietary fibre to treat non- alcoholic fatty liver disease (NAFLD) in children with obesity. This dietary fibre supplement is known…
PI: Reed, David E; De Palma, Giada
This proposal seeks to find novel treatments for abdominal pain in patients suffering from chronic abdominal pain, such as those with the irritable bowel syndrome (IBS). Unfortunately, many pain medi…
PI: Hawke, Thomas J; Macdonald, Maureen J
Type 1 Diabetes (T1D) results when the body destroys the insulin-producing beta cells of the pancreas. While insulin injections are essential for managing T1D, they are not a cure and do not prevent …
An accumulation of fat in the liver can lead to inflammation, which can be very severe in some people, and can even lead to cirrhosis. This disease is called fatty liver disease. In recent years, res…
Misuse and addiction to natural and synthetic opioids is a serious public health crisis nationwide that has become an epidemic. In only the first three months of 2020, 1,018 opioid-related deaths wer…
PI: Dubé, Marie-Pierre; Carpentier, André C; Tardif, Jean-Claude
There are several drugs available for the treatment of patients with type 2 diabetes (T2D) which have different mechanisms of action and provide variable benefits between patients. In T2D patients wh…
Gestational diabetes mellitus (GDM), defined as glucose intolerance first recognized during pregnancy, affects up to 14% of pregnancies worldwide. A GDM pregnancy significantly increases the risk of …
PI: McGlory, Christopher; Phillips, Stuart M
During periods of bedrest, we are in a state of inactivity and lose a significant amount of muscle. A good example of this phenomenon is when a person comes home from a hospital stay and their limbs …
Heart attacks, heart failure and stroke combined are a leading cause of reduced quality of life and death in Canada, and are caused primarily by the buildup of plaque in arteries in a disease called …
PI: Chun, Justin
Diabetic kidney disease is the number one cause chronic kidney disease and end stage kidney disease. Patients with diabetic kidney disease have buildup of fat molecules called lipid droplets in their…
PI: Szaszi, Katalin
Injury is a key contributor to chronic kidney disease leading to scarring (fibrosis), and ultimately kidney failure. Diseases, such as high blood pressure and diabetes cause ongoing injury that resul…
PI: Barbour, Sean; Canney, Mark; Fordyce, Christopher B
Glomerulonephritis (GN) is a group of autoimmune diseases that attack the kidneys and is the second most common cause of kidney failure requiring dialysis or a kidney transplant in Canada. Unlike mos…
Mechanisms and function of wrappER contacts with mitochondria and peroxisomes in health and disease
PI: Pellegrini, Luca
The liver is responsible for managing lipids, mostly cholesterol and triglycerides. It does so by absorbing them from the blood when they are in excess and releasing them in circulation when they are…
PI: Santosa, Sylvia
With obesity, expansion of fat tissue in different depots results in fat that does not work properly. When fat does not work properly, the fat contributes to the development of metabolic diseases suc…
Obesity kills over 4 million people every year worldwide. Meanwhile, more and more are diagnosed with type 2 diabetes (T2D) and its cardiovascular complications. This is especially so in women. Abnor…
PI: Bandsma, Robert
Malnutrition is related to 45% of all childhood deaths globally. Children with malnutrition generally do not die from malnutrition directly, but malnutrition makes them vulnerable for common infectio…