CIHR Projects
Browse 44179 CIHR-funded research projects
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PI: Sears, Carly S
Chronic non-cancer pain, encompassing several multifaceted conditions, imposes substantial personal and societal burden worldwide, with yearly costs of approximately $40 billion in Canada alone. Due …
Childhood brain cancer occurs at a critical stage of physical and cognitive development. Although treatments have improved in the past two decades, the severity of the disease and the intensity of th…
PI: Leung, Chelsea
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein 9 (Cas9) is a gene-editing technology that can be used to treat disease. One impactful potential applicati…
PI: Gupta, Keshav
Rhabdomyosarcoma (RMS) is the most common soft-tissue cancer in children and has a particularly poor prognosis with a 5 year survival rate of 30% in individuals with metastatic (spreading throughout …
PI: Lowe, Catherine
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition that affects up to 10% of children, characterized by inattention, impulsivity, and hyperactivity symptoms. Perinatal …
A Three Dimensional Evaluation of NK cell Prognostic Impact on High Grade Serous Ovarian Cancer
Among all gynecological malignancies high-grade serous carcinoma (HGSC) is the deadliest and most common. It is nicknamed the silent killer because it is detected at later stages and has a poor survi…
PI: Russell, Emily L
Chronic obstructive pulmonary disease (COPD) affects 17% of Canadians aged 40 years, and is characterized by abnormal circulating levels of systemic and lung-specific inflammatory biomarkers, which i…
Association of occupation with lung function decline in high-, middle-, and low-income countries
PI: Moinuddin, Ali
The World Health Organization and International Labour Organization (WHO/ILO) have attributed 1.9 million deaths globally to occupational exposures in 2016. The long-term effects of many occupational…
PI: Al Sharani, Sara
Background: Unhealthy food marketing to children adversely affects their diet quality and health. The negative impacts of this marketing may be amplified on digital media, which allows industry to us…
PI: Yu, Richard X
A concussion, also known as a mild traumatic brain injury, is caused by biomechanical forces. Due to the complexity of this injury, many individuals with a concussion still have persistent symptoms p…
The Human Milk Oligosaccharide Status in Women With and Without Gestational Diabetes Mellitus
PI: Churchill, Megan
Gestational Diabetes Mellitus (GDM) is a maternal intolerance to glucose (a simple sugar) that can develop during the second to third trimester of pregnancy (20-32 weeks). Human milk (HM) is consider…
PI: Forder, Aisling
Nasopharyngeal carcinoma (NPC) is a cancer that forms in the throat at the level of the nose. The location of the tumour makes it very difficult to detect early, when it is still small, as it does no…
PI: Liu, Mingxin
Rationale: Ageism, i.e., ;stereotype, prejudice, and discrimination directly towards people because of their age, may contribute to various adverse health outcomes and increase the burden on health a…
PI: Hou, Sophia
People of colour and members of the LGBTQ+ community experience higher rates of disease and mental health issues compared to White and cisgender/heterosexual people. These outcomes are worsened by da…
Family caregivers play an important role in the care and support of patients. In fact, they are in a unique position to relieve much of the responsibility from the notoriously burdened medical system…
PI: Trkulja, Kyla L
The nuclear export protein Exportin 1 (XPO1), which carries proteins, ribosomal subunits, and RNA into the cytoplasm, is overexpressed in almost all patients with solid and hematological cancers. Sel…
PI: Feighan, Kira M
Synaptic plasticity, the activity dependent changes in efficacy and strength of synaptic connections in the adult brain, is thought to underlie learning and memory formation. Netrin-1 is a protein th…
PI: Shoukry, Roaa
Children with disorders that impact their neurodevelopment find it more difficult to regulate their emotions and behaviour. This dysregulation arises from executive function impairments that characte…
PI: Rioux, Mathilde
There are no effective treatments for persistent memory symptoms following concussion. Cognitive rehabilitation, the current standard of care, may be misguided because it focuses on adapting to perma…
The essential role of innate immunity, the bodys first line of defence, in pathogen clearance is reflected by its remarkable existence and diversity at every level of the evolutionary tree of life. I…
The teenage pregnancy rate in Northern British Columbia (NBC) is the highest in the province. Compared to adults, pregnant, birthing, and early parenting (PBEP) adolescents are at greater risk for ad…
Thrombosis is a pathological condition that occurs as a result of unregulated blood clotting that occludes blood vessels, leading to conditions such as heart attack and stroke. Despite the availabili…
PI: Gray, Aidan
The focus of this project is on a type of breast cancer called triple-negative breast cancer (TNBC) that is very aggressive and has a poor prognosis. It affects mainly young women in the prime of lif…
The Fort McMurray wildfire began in May 2016, destroying homes and forcing its inhabitants to flee the city, including pregnant women. Prenatal stress due to past natural disasters has been associate…
PI: Liu, Yi Ran
One of the most common and debilitating diseases of the digestive tract is inflammatory bowels disease (IBD), which can cause damage to the gastrointestinal tract due to chronic inflammation. Over th…
Spinal cord injury is an extremely debilitating condition with a complex pathology and no cure. The main obstacles to spinal cord regeneration appear to be poor intrinsic capacity for regrowth in the…
PI: Soliman, Rania
Most patients who have pelvic radiotherapy (RT) as a treatment for cancer experience some degree of acute gastrointestinal (GI) and genitourinary (GU) toxicities. All patients must have access to wel…
PI: Al-Khaz'Aly, Ali
All living cells produce unique vibrations due to internal metabolic processes which have previously been recorded using Atomic Force Microscopy (AFM). These studies have established proof of concept…
Disruption of synaptic communication by genetic disorders, aging, viral infections, and other agents is one of the leading underlying causes of brain disorders, such as Alzheimer's disease, intellect…
Preterm birth is the world's leading cause of death for children under the age of 5. Yet, there are no effective medications to safely prevent this condition. Prostaglandin F2alpha (PGF2alpha) is a b…
PI: Wang, Yi Ran
Age-related hearing loss, or presbycusis, is the most common health condition in the elderly after hypertension and arthritis. Presbycusis is thought to be associated with cognitive decline and may b…
Inflammatory bowel disease (IBD) is a major health burden in Canada. Incidence of IBD has increased substantially in recent years, and Canada has among the highest rates of IBD globally. Although the…
Investigating the impact of PGC-1a-coupled metabolic reprogramming on breast cancer metastasis
An increasingly recognized feature of cancer is its ability to make alterations to metabolism to meet the high energy demands of rapidly growing tumours. The ability to reprogram their metabolism als…
PI: Torrens, Aidan
Drug resistance is a major medical challenge leading to low survival rates amongst diseases like lung cancer, the most diagnosed cancer in Canadians. Cisplatin is the current standard of care, but dr…
Depression is a debilitating illness affecting 20% of the population that is characterized by depressed mood and disrupted cognition. Compared to males, females are twice as likely to develop depress…
Prince Albert Saskatchewan is a region that is experiencing high rates of substance use compared to provincial and national averages. This has led to an increase in health and social services demands…
PI: Grewal, Haskirat
Spinal cord injury (SCI) is a traumatic event affecting 1.3 million North Americans and is associated with severe physical, psychological, social, and economic burdens on patients and their families.…
PI: Zheng, Alice
Autism spectrum disorder (ASD) is a neurodevelopmental condition that has been diagnosed in approximately 1 out of 66 children between 5 to 17 years of age in Canada. Altered sensory processing is co…
PI: Marotta, Justin
The biomedical field has seen an increased use of miniature power-efficient chips as neural prostheses. These chips are implanted in the brain to help treat neurological diseases such as epilepsy and…
PI: Steele, Brian
Suicide is a leading cause of mortality in Canada. The etiology of suicide is multifaceted and includes social factors, which are relevant for equitable interventions. One social factor of interest i…
Assessing Visually Induced Motion Sickness in a Diverse Population of Female Stroke Survivors
PI: Fox, Summer A
Femalestroke survivors access rehabilitation services less than male stroke survivors, and they are underrepresented in rehabilitation research. This suggests that treatments are not being tested equ…
Spinal Cord Injury (SCI) is one of the leading causes of disability, and although rehabilitation strategies are common, there is a need for new treatment options that focus on the regeneration of cel…
1-2% of infants and toddlers need surgery annually. Managing their pain after surgery is challenging. Opioids are commonly used but have many side effects. Due to these side effects, doctors use mult…
A novel immunotherapy for Rheumatoid Arthritis: targeting citrullinated epitope-specific T cells
PI: Malhotra, Devon
Rheumatoid arthritis (RA) is a chronic, autoimmune disease that primarily affects the joints of the hands, knees, and feet of about 1 in every 100 individuals. In RA, the bodys immune system mistaken…
PI: Boudaa, Sarah
Les maladies cardiaques peuvent affecter le cerveau et augmenter les risques de démence. Des études récentes suggèrent qu’une augmentation chronique de la pulsatilité cérébrale pourrait contribuer au…
Cancer mortality rates can be greatly ameliorated by improving early diagnosis mechanisms and routinely screening the population. However, most tumour diagnosis methods are highly invasive and unfeas…
SARS-CoV-2 the respiratory virus responsible for millions of deaths around the world since its first appearance in 2019 , in Wuhan, China. Despite the high vaccination rates, the danger of COVID-19 p…
PI: Wang, Nicole I
Invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells are unique subsets of T cells that have been shown to be involved in regulating immune responses to tumors and …
Développement d'un modèle de peau 3D à double composante immunitaire pour l'étude du psoriasis
Le psoriasis est une maladie cutanée inflammatoire complexe impliquant une variété de cellules tissulaires et de cellules de l’immunité innée et adaptative. Cette dermatose est plus particulièrement …
PI: Radadia, Nisarg
Lung cancer is common in Canada. For people diagnosed with early-stage lung cancer, the ideal course of treatment is for the tumor to be surgically removed. However, lung complications are common adv…