CIHR Projects
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Showing 51-100 of 7698 projects for "cancer"
PI: Mazzoli, Vienna
Current cancer therapies, such as chemotherapy, are largely non-specific and cause systemic side effects. Modern advances in cancer therapeutics involve the development of personalized smart drugs to…
PI: Mslati, Hazem
Proteolysis targeting chimera (PROTAC) aims at selectively degrading biological targets of interest (TOI) intracellularly using host cell's ubiquitin ligases thereby achieving lasting ablation of act…
PI: Nam, Alice Jisoo
In recent years, DEP-domain containing mTOR-interacting protein (Deptor) has been identified as an endogenous inhibitor of mammalian target of Rapamycin (mTOR), the master regulator of cellular growt…
PI: Gordon, Benjamin
Our immune systems can recognize foreign invaders such as viruses and bacteria resulting in the generation of immune responses. In the context of cancer, many of these diseased cells express antigens…
PI: Moore, Allyson E
Glioblastoma multiforme (GBM) is the most common and aggressive primary adult brain tumour. Despite multimodal management patients currently face a median survival of 15 months and disease recurrence…
PI: Baerg, Lauren
It is estimated that the population of bacteria that live in our gut, known as the gut microbiota, outnumber the cells of the human body 100 times. The diversity of microbial species and their capabi…
Targeting Lysine-specific Demethylase 1 to Enhance the Post-transplant Graft-versus-leukemia Effect
PI: Yan, Yu
Acute myeloid leukemia (AML) is an aggressive blood cancer with a 5-year survival rate of 21%. AML occurs when the bone marrow produces a large number of unhealthy cells that prevent the growth and f…
PI: Pastor, Nadielda
Problématique: le Parcours de formation axée sur l’emploi (PFAE) du ministère de l’Éducation offre chaque année une alternance études-travail à 10 000 jeunes de 15 ans et plus. Il leur permet d’acqué…
Oncolytic virotherapy is a form of cancer therapy that utilizes oncolytic viruses (OVs) to preferentially infect and kill tumour cells. We have previously demonstrated that some OVs in clinical trial…
Discriminating Metabolic Health Status in a Cohort of Nursing Students: A Cross-Sectional Study
PI: Lowes, Shanna L
Obesity has become an increasingly problematic health issue worldwide. Obesity is one of the factors that determines an individuals metabolic health, along with blood pressure, blood sugar, and fat l…
As cancer progresses, it can spread from the original tumor to distal organs/tissues through a process called metastasis. One target metastatic site is the brain, where formation of metastases is dea…
PI: Chen, Angie
Colorectal cancer is a common and deadly cancer with two subtypes: the CIN subtype, which has poor patient survival, and the MIN subtype, which has better patient survival. This higher survival in MI…
Patient-specific dose escalation during brachytherapy using multiparametric MRI in cervical cancer
PI: Umolac, Troy M
Cervical cancer is the fourth most common cancer in females worldwide. Standard treatment for locally advanced cervical cancer is the combined use of radiation therapy and chemotherapy. Radiation kil…
The most common cancer in children is Acute Lymphoblastic Leukemia, or ALL. The cancer cells in ALL cannot make the amino acid asparagine. Instead, the cells get asparagine from the blood. We treat A…
PI: Dawson, Alice A
Head and neck cancer is the 6th most common cancer in the world. It typically arises in the lining of the mouth, neck, and throat and is collectively referred to as head and neck squamous cell carcin…
PI: Bherer, Juliette
En 2019, le cancer du sein était la deuxième cause de décès par cancer chez la femme au Canada. Cette maladie se divise en plusieurs sous-types selon l’expression du récepteur aux œstrogènes ?, à la …
PI: Wen, Timmy T
Hypertranscription is defined by a global increase of RNA output in a cell. It is an abnormality of a cell's transcriptional machinery best characterized in cancer cell lines and stem cell models. Th…
Newer targeted cancer therapies, including epidermal growth factor receptor inhibitors, have fewer systemic side effects than older chemotherapy but cause a near-universal acneiform rash. This rash l…
The production of recombinant soluble prorenin receptor to study its effect on cancer metabolism.
PI: Krauss, Daniel
The Prorenin Receptor (PRR) is a single-spanning transmembrane protein. It is cleaved to form an N-terminal secreted fragment called secreted PRR (sPRR), and a short transmembrane C-terminal fragment…
PI: Mei, Ruoyu
Broadly speaking, cancers are diseases stemming from mutations which cause abnormal cell growth, movement and behaviour. About a quarter of human cancers are driven by mutations in genes encoding Ras…
Investigating resident macrophages in the leukemic bone marrow niche by probing the CD82-DARC axis
The bone marrows (BM) main job is to produce the blood cells of our immune system in a process called hematopoiesis. In leukemia, the BM becomes filled with cancerous blood cells, which prevents norm…
Acute Myeloid Leukemia (AML) is a common, aggressive type of leukemia. The progression of AML depends on the function of cells called leukemic stem cells (LSCs). Research shows that AML patients with…
PI: Linteau, Naomie
Des mutations fréquentes de cellules cancéreuses touchent les complexes protéiques mSWI/SNF. Ces assemblages de protéines sont essentiels à l’initiation du cancer du foie, car ils régulent l’utilisat…
PI: Medawar, Edgard
Colorectal cancer is the second cause of cancer deaths and the third most common cancer worldwide. The main screening modality is colonoscopy, a procedure where the bowel is visualized with a camera …
PI: Kerba, Johanne
Grâce aux avancées thérapeutiques, le taux de survie des enfants et adolescents atteints de cancer est de 80%. Toutefois, la période de traitement demeure difficile en raison des effets secondaires i…
PI: Lynn, Matthew J
Lung cancer is the most diagnosed cancer and the leading cause of cancer deaths in Canada. Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, but primary response rates to immune ch…
PI: Cheong, Ian
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest types of cancer, with only 8% of patients surviving beyond five years. The poor prognosis of patients with PDAC highlights a need …
PI: Garneau, James
Insomnia affects between 30 to 60% of cancer patients at any given time. The current gold standard for treating insomnia is cognitive behavioural therapy for insomnia (CBTi), however accessibility to…
Human Herpesvirus 6A/B (HHV6A/B) are two viruses currently present in over 90% of our population, remaining in the body for life following infection. The consequences of this are not well characteriz…
Investigating the mechanisms of DNA release from cancer cells in esophageal adenocarcinoma patients
Esophageal adenocarcinoma (EAC) is characterized by low survival rates and has had an increase in incidence in recent decades. Liquid biopsies from EAC patients have the potential to improve diagnosi…
PI: Duong, Nathan
My proposed research involves looking at the interleukin-23/interleukin-23 receptor (IL-23/IL-23R) pathway in the context of acute myeloid leukemia (AML). Preliminary data for this project indicates …
PI: Chan, Jennifer
Pancreatic ductal adenocarcinoma (PDAC) is a major class of pancreatic cancers that accounts for more than 90% of diagnosed cases. Fast progression, late-stage diagnosis, and drug resistance are amon…
Des défauts moléculaires à l’enveloppe nucléaire sont à l’origine ou contribuent à des maladies humaines incluant des cancers et des dystrophies. Une meilleure connaissance des mécanismes moléculaire…
Cancer remains the primary cause of death in Canada due to its ability to spread throughout the body, and create secondary complications of cancer-associated thrombotic disease, or in other words a b…
PI: Yang, Zi Ling
Cancer immunotherapy works by using the bodys own immune system to treat cancer. A type of immunotherapeutic known as ;molecular adapters work by binding immune cells and linking them to targeted tum…
PI: takdenti, meriem
Malgré les progrès de la recherche et le développement de nouvelles thérapies anticancéreuses ciblées, le cancer représente la principale cause de mortalité dans le monde en général et au Canada en p…
PI: Cai, Renying
Some viruses can make us very sick, but we then get better because our immune system fights them off. Other viruses can last a lifetime, such as HIV or hepatitis C, where our immune system cant get r…
PI: Joynt, Alyssa C
Lynch syndrome (LS) is the most common cause of inherited colorectal cancer (CRC). LS is caused by inherited changes in one of four DNA mismatch repair (MMR) genes, resulting in an increased risk for…
PI: Bennett, Jillian
The standard of care for locally advanced cervical cancer includes external beam radiation therapy (EBRT) with concomitant chemotherapy, followed by brachytherapy (BT). BT involves the positioning of…
The cell is the basic building block of life. The human body is composed of trillions of cells. Inside the cell, there are several machines, or organelles, which serve specific and essential roles. E…
PI: Touma, Nawar
Prostate cancer (PCa) has the second leading cancer-specific mortality in Canadian men. At time of diagnosis, cancer's aggressiveness is determined to predict the risk of mortality. Molecular imaging…
PI: Durland, Lauren
Cancer affects a substantial portion of the Canadian population; however, a universal cure remains elusive. Recent approaches to cancer treatment have focused on T cells, an important type of immune …
Extracellular vesicle protein signatures of pediatric liver tumors - A novel strategy for diagnosis
Hepatoblastoma (HB) is the most frequent pediatric liver tumor. Standard treatment involves diagnostic imaging, biopsy, chemotherapy and surgery. Since most children are diagnosed under the age of 5 …
The mitochondria is responsible for food metabolism and energy production inside the human body. In response to diverse mitochondrial stressors, eukaryotic cells initiate two distinct pathways, mitop…
Investigating the immunopathogenesis of hepatitis B virus using the woodchuck hepatitis virus model
PI: Al-Yasiri, Layla
Hepatitis B virus (HBV) has established chronic infections in more than 296 million individuals worldwide and is associated with liver cancer and cirrhosis. Lifelong regiments of nucleos(t)ide analog…
Monoclonal B-cell lymphocytosis (MBL) is a pre-condition of chronic lymphocytic leukemia (CLL), which is associated with weakened immunity and greater vulnerability to infections and cancer developme…
Le cancer de la prostate est l’un des cancers les plus diagnostiqués chez les Canadiens. Bien que de nombreuses options de traitement sont disponibles pour les patients, le cancer de la prostate caus…
PI: Her, Peter
Researchers have long focused on how unexpected and permanent changes in our genetic makeup, or DNA leads to diseases like cancer. However, just looking at DNA might not be giving us the full picture…
PI: Mazzone, Ryan J
The epithelial cells that line the intestine not only function in nutrient absorption, but also serve as a crucial barrier that protects against microbial infection. Within these cells, NOD-like rece…
Investigating the in vitro and in vivo effects of cannabis smoke exposure on lung cancer development
PI: Wang, Peiyao
With rapid legalization and decriminalization of cannabis, there is a growing need to understand its specific effects, particularly through smoking, the main method of consumption. Current literature…