CIHR Projects
Browse 1384 CIHR-funded research projects
Search & Filter Projects
Showing 51-100 of 1384 projects for "covid"
Despite an extensive effort to tackle the COVID-19 pandemic in Canada, some populations were hit harder by the COVID-19 and have been facing additional barriers to coping with its effect on their hea…
PI: Sharlin, Noga
SARS-CoV-2 is the virus responsible for the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. The symptoms of COVID-19 vary from mild illness to severe disease leading to hospitalization or de…
PI: Bhartt, Taran P
To prevent complex infections like HIV-AIDs, malaria, and COVID-19, the next generation of vaccines will need to stimulate all branches of the immune system, not just antibody-based ;humoral immunity…
PI: Benlarbi, Mehdi
In December 2019, several pneumonia outbreaks emerged in China, all related to the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The high transmissibility of SARS-CoV-2 caused t…
PI: Panjwani, Azra A
Background: In 2020, there were 6265 opioid poisoning deaths in Canada, marking the most devastating year for overdose deaths. During the COVID-19 pandemic, access to substance use related supports h…
Longitudinal Mental Health Symptom Changes Prior to and During COVID-19 Among At-Risk Populations
In addition to causing over 4.5 million deaths, the COVID-19 pandemic has led to extensive disruption in peoples social and economic lives. Some groups of individuals, such as women and ethnic minori…
The coronavirus family encompasses three pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV), which have the capability of infecting humans causing cytokine storms, acute respiratory distress…
During the COVID-19 pandemic, researchers and clinicians have sought to understand why people experience drastic differences in symptom severity when infected with SARS-CoV-2.Antibodies produced by t…
PI: Jansen, Ethan
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) causes the disease known as COVID-19 (coronavirus disease 2019). Currently, the long-term outcomes of SARS-CoV-2 infection are poorly unde…
PI: Rayner, Daniel
Despite advancements in diagnostic and therapeutic tools, heart failure (HF) is a growing epidemic in Canada and remains a major public health concern. The COVID-19 pandemic has only worsened this si…
PI: Duncan, Maggie C
Antiretroviral therapies have transformed HIV from a life-threatening infection to a manageable health condition, but these drugs must be taken for life. This is because HIV establishes a latent rese…
Ce projet de recherche a pour objectif d’explorer l’effet d’un type de réseaux sociaux (Instagram) sur les perturbations de l’image corporelle auprès de populations présentant des attitudes et compor…
Eating disorders (EDs) are life-threatening mental illnesses with serious health consequences. Despite having the highest mortality rate of any mental disorder, individuals with EDs are far less like…
PI: Sandhu, Monique
Illicit drug use is associated with severe health and social harms among young people, which have been further exacerbated in the context of the overlapping overdose and COVID-19 crises in Greater Va…
Prenatal stress and subsequent maternal pain associated with altered brain development in children
PI: Jessa, Jenna
Chronic pain is a major public health issue, affecting one in five Canadians. The estimated costs of chronic pain in Canada are $60 billion CAD per year. Chronic pain impacts social, emotional, and d…
PI: Ncube, Nokuzola
Intimate partner violence (IPV) is any form of abuse maintained by an intimate partner with some examples including physical, sexual, emotional, and financial abuse. In response to the COVID-19 pande…
Antimicrobial resistance is quickly emerging as one of the most important threats to global health. As an increasing number of microorganisms continue to develop resistance to current treatments, exp…
The COVID-19 pandemic is caused by SARS-CoV-2, which has infected over 261 million people and caused over 5 million deaths worldwide. Pregnant women have been especially affected by COVID-19, leading…
Errant epitopes from arginine methylated SARS-CoV-2 proteins predisposing to autoimmune diseases
PI: Khan, Sarah M
The SARS-CoV-2 nucleocapsid (N) protein is the most abundant protein expressed in virions and infected cells. It contains five RGG/RG motifs, preferential sites for protein arginine methyltransferase…
PI: Smaill, Fiona M; Comeau, Jeannette L; Gauvreau, Gail M; Halperin, Scott A; Langley, Joanne M; Loeb, Mark B; Miller, Matthew S; Satia, Imran; Wang, Jun; Xing, Zhou
Despite the benefit of current COVID vaccines in preventing severe disease and death, these vaccines are relatively poor at preventing infection with new variants like Omicron and work less well in t…
PI: Bourbeau, Jean; Anderson, David R; Batist, Gerald; Bell, Emily C; Benoit, Britney L; Collister, David; Dasgupta, Kaberi; Fahim, Christine; Fergusson, Dean A; Filion, Kristian B; Gahagan, Jacqueline C; Goos, Lisa; Khan, Nadia A; King, Malcolm; Li, Linda C; Mitra, Souvik; Morin, Suzanne N; Pilote, Louise; Reiman, Tony; Richer, Lawrence P; Saleh, Ramy R; Sapp, John L; Tomblin Murphy, Gail G; Yeh, Ann E.
COVID-19 pandemic has highlighted the importance for Canada to have the capacity to run large clinical trials and no longer be only reactive but responsive in leading with increase capacity and quali…
PI: Rochwerg, Bram N; Del Sorbo, Lorenzo; Fan, Eddy; Ferguson, Niall D; Goligher, Ewan C
Acute hypoxemic respiratory failure (AHRF), or acute breathing problems, are one of the most common reasons to require hospital admission, or in the most severe cases, admission to the intensive care…
PI: Quach-Thanh, Caroline; Galanis, Eleni; Strang, Robert A; Basta, Nicole; Bhatt, Maala; Buchanan, Francine; Constantin, Evelyn; Côté, Sylvana; Drouin, Olivier; Dugas, Marc-André; Fontela, Patricia S; Foo, Cheryl P; Foster, Jennifer; Freedman, Stephen B; Gagneur, Arnaud A; Gantt, Soren M; Gill, Peter J; Kakkar, Fatima; Kellner, James D; Klassen, Terry P; Lacaze-Masmonteil, Thierry; Lalgudi Ganesan, Saptharishi; Li, Patricia T; Mahant, Sanjay; Mater, Ahmed; Muttalib, Fiona; Papenburg, Jesse; Sadarangani, Manish; Sehgal, Anupam V; 't Jong, Geert W; Wahi, Gita; Wright, Bruce
Throughout the course of the COVID-19 pandemic in Canada, infection and transmission among children has progressively increased, due to more transmissible SARS-CoV-2 variants and relatively low rates…
The COVID-19 pandemic has spread quickly around the world and has had unprecedented effects on societies, including disease management and health care systems. COVID-19 was described initially as a r…
Canadian ADAptive Platform Trial of COVID-19 Therapeutics in Community Settings (Can-ADAPT COVID)
PI: Pinto, Andrew D; Keynan, Yoav; Greiver, Michelle; JĂĽni, Peter; Lee, Todd C; McDonald, Emily G; Murthy, Srinivas; Selby, Peter L
While public health measures and vaccines have reduced the spread of SARS-CoV-2, most scientists predict this virus will be endemic and new variants will emerge. Effective and affordable medications …
People with dementia and their informal carers who live at home have experienced significant negative impacts of COVID-19 control measures (e.g. social restrictions, reallocation of resources) and th…
PI: Fowler, Robert A; Adhikari, Neill K; Archambault, Patrick; Bagshaw, Sean M; Binnie, Alexandra; Chasse, Michael; Cook, Deborah J; Daneman, Nick; Fiest, Kirsten M; Fox-Robichaud, Alison E; Goligher, Ewan C; Herridge, Margaret S; Kho, Michelle E; Lamontagne, Francois; Lawler, Patrick R; Lee, Todd C; Marshall, John C; McDonald, Emily G; McNally, James D; Meade, Maureen O; Mehta, Sangeeta; Menon, Kusum; Murthy, Srinivas; O'Hearn, Katharine J; Piquette, Dominique; Rochwerg, Bram N; Russell, James A; Tsang, Jennifer L; Turgeon, Alexis F; Wollny, Krista; Yada, Nicole; Zarychanski, Ryan
To date over 3.6 million Canadians have been diagnosed with COVID-19 infection. Of these, 15-20% have been hospitalized, and over one-quarter have been admitted to ICU. Unfortunately, there have been…
PI: Mahmood, Bushra
Background COVID-19 and pandemic response measures implemented to limit its spread have resulted in various indirect health impacts due to the disruption of many preventative, diagnostic, and managem…
Multimorbidity is when an individual has two or more chronic diseases. But, behind this simple definition lies a complex phenomenon. Chronic diseases interact, and their combined health impacts can b…
PI: AbuRaed, Ahmed G
The illicit drug overdose crisis in North America has had a profound impact on individuals, families and communities, often leading to premature loss of life and lowering of life expectancy. Since 20…
PI: Raza, Sarah
Autism is the most common and fastest growing neurodevelopmental condition in Canada. Early diagnosis is critical to promote access to interventions and supports to help children reach their fullest …
The COVID-19 pandemic greatly affected long-term care in Canada, exposing gaps in the provision of care for a vulnerable aging population. Moreover, the pandemic revealed a lack of information collec…
PI: Myge, Ivy
There has been a longstanding call for long-term care (LTC) to use models of care that are more person-centered. However, the disruptions that occurred in LTC as a result of restricted family and vol…
It has become increasingly common that aging members of our population require healthcare services to support them. Many Canadians spend their final years in long-term care (LTC) facilities as a resu…
Each year, 70,000 patients are harmed in hospital, despite decades of trying to make the healthcare system safer for them. This harm is not intentional and can be a result of miscommunication between…
PI: Bashir, Kainat
Issues involving the introduction, learning and embracing of new knowledge, innovation or practice change in healthcare are critical as the innovation impacts the quality of service and care of patie…
PI: Fowler, Robert A; Adhikari, Neill K; Archambault, Patrick; Bagshaw, Sean M; Binnie, Alexandra; Chasse, Michael; Cook, Deborah J; Daneman, Nick; Fiest, Kirsten M; Fox-Robichaud, Alison E; Goligher, Ewan C; Herridge, Margaret S; Kho, Michelle E; Lamontagne, Francois; Lawler, Patrick R; Lee, Todd C; Marshall, John C; McDonald, Emily G; McNally, James D; Meade, Maureen O; Mehta, Sangeeta; Menon, Kusum; Murthy, Srinivas; O'Hearn, Katharine J; Piquette, Dominique; Rochwerg, Bram N; Russell, James A; Tsang, Jennifer L; Turgeon, Alexis F; Wollny, Krista; Yada, Nicole; Zarychanski, Ryan
To date over 3.6 million Canadians have been diagnosed with COVID-19 infection. Of these, 15-20% have been hospitalized, and over one-quarter have been admitted to ICU. Unfortunately, there have been…
PI: Campbell, David J; Donald, Maoliosa (Mo); James, Matthew T; Manns, Braden J; Pannu, Neesh I; Tsuyuki, Ross T
People with conditions like diabetes, kidney disease, and heart disease take medications that protect them from complications; yet, these same medications may be harmful during times of illness (such…
PI: Beall, Reed; Baral, Stefan D; Janjua, Naveed Z; Katz, Alan; Maheu-Giroux, Mathieu; Mishra, Sharmistha; Williamson, Tyler
The introduction of new health innovations that bring substantial health benefits for those who receive them, such as vaccines against COVID-19, is very challenging. Challenges can include unequal ac…
Exposure to traumatic events can result in the development of post-traumatic stress disorder (PTSD), a common, serious, and complex mental health condition. Undoubtedly, the COVID-19 pandemic has bee…
PI: Razak, Fahad; Baker, Andrew J; Chan, Timothy; Gibson, Jennifer; Leung, Elizabeth; Mamdani, Muhammad; Morris, Andrew M; Pai, Menaka; Rosella, Laura C; Sarhangian, Vahid; Siddiqi, Arjumand; Verma, Amol
The COVID-19 pandemic resulted in an urgent need for effective therapeutics to treat hospitalized patients with severe infections. In less than two years, new drugs were developed and existing medica…
PI: Brignardello Petersen, Romina Andrea; Guyatt, Gordon H
After the COVID-19 pandemic started, researchers focused on assessing treatments for this disease. Global and local authorities (such as the World Health Organization (WHO) and the Public Health Agen…
PI: Montesanti, Stephanie R; Wells, Lana M
During the COVID-19 pandemic, there was a surge in domestic and sexual violence (DV/SV). Although many organizations were collecting information on DV/SV, there was no centralized structure to combin…
Addressing the COVID-19/malaria interface at health centres in the Democratic Republic of Congo
With the COVID-19 pandemic jeopardizing two decades of progress against malaria in Africa, approaches to supporting health workers on the frontlines of managing both diseases are urgently needed. Hea…
Characterization of the antiviral mechanisms of cyclophilin inhibitors against coronavirus infection
PI: Colpitts, Che C
The COVID-19 pandemic has underscored the severe threat posed by emerging coronaviruses. In the absence of effective broadly-acting antiviral therapies against coronaviruses, we are vulnerable to cor…
PI: Denis, Jean-Louis; Forest, Pierre-Gerlier; Lavis, John N
The COVID-19 pandemic underlines the importance of global health issues and the important role that public authorities at all levels of government must play to detect and contain the outbreak. Despit…
Total hip and knee replacements (TJR) for osteoarthritis are common orthopaedic procedures performed in Canada. Waits for these procedures are already lengthy, and the COVID-19 pandemic has further d…
PI: Yeung, Rae S; Benseler, Susanne; Haddad, Elie
COVID-19 can cause a life-threatening Multisystem Inflammatory Syndrome in Children (MIS-C) typically weeks after a mild or even asymptomatic infection. Each wave of COVID-19 cases is closely followe…
COVID-19 is an acute respiratory illness caused by SARS-CoV-2. COVID-19 has caused > 223 million infections and >4.1 million deaths. Most infected people are mildly symptomatic; however, ~5% suffer r…
PI: Victoria Ansalem, Anil Kumar
Coronavirus disease-19 (Covid-19) pandemic is the biggest global health crisis in recent history, resulting in over 4.5 million deaths worldwide. Covid-19 is caused by SARS-Coronavirus-2, a novel cor…