CIHR Projects
Browse 2832 CIHR-funded research projects
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Showing 51-100 of 2832 projects for "diabetes"
PI: Sarma, Sisira K
Stronger primary health care systems are associated with better health outcomes compared to those with weaker systems. Reforms introduced worldwide to address better access to primary care, preventiv…
Skeletal muscle energetics and metabolic programming in treatment -sensitive and -resistant obesity
The causes of obesity are complex and currently available treatments are often not effective. Why some people are more at risk than others for obesity and obesity-related diseases is not well underst…
When infants are exposed to perturbed nutrition shortly after birth, their metabolism can be altered permanently. For example, if infants are premature or ill at birth, they may require intravenous n…
PI: Côté, Jacques
All cells in a multicellular organism contain the same genetic material. Despite this fact, different cell types must carry out different functions. How each cell expresses the required proteins at t…
PI: Indigenous Diabetes Health Circle, .; buchanan, maureen
Aki Gimiinigonaa Mshkooziiwin (The Land Gives Us Strength): Culturally-grounded healing within the urban-Indigenous community during COVID-19 is an urban Indigenous community-led knowledge mobilizati…
PI: Puts, Maria (Martine) T; Alibhai, Shabbir M; Chesney, Tyler; Munteanu, Cosmin
Older adults often have chronic health conditions such as heart disease, diabetes and cancer. Almost half of all inpatient surgeries are for older adults. However, older adults are at greater risk fr…
PI: Shah, Baiju R; Mulder, Carol
Nearly 2½ million people are affected by diabetes in Canada, but rates among First Nations people are much higher compared to other people in Canada. We recently completed a collaborative project bet…
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth. Importantly, T1D is strongly associated with heart diseases such as heart attacks and strokes, known as ca…
Peripheral arterial disease and diabetic foot ulcer are a major risk factor for lower-extremity amputation and a major cause of morbidity and premature death in patients with diabetes. Evidence sugge…
Obesity is a major global health concern, especially in Western society where it is estimated that 65% of the population is overweight. Obesity is a major risk factor for other disorders, including d…
Our vision is to establish a complete understanding of the biology of human beta cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabet…
PI: Advani, Andrew
Kidney disease is one of the most devastating complications of diabetes. We urgently need new treatments. Sometimes kidney disease in diabetes develops gradually over years. This is called chronic ki…
A healthy brain requires a healthy body. It is increasingly recognized that by improving the general metabolism of the body, one can improve brain function. This may be particularly true for Alzheime…
Gestational diabetes mellitus (GDM), defined as high blood sugar that is first recognized during pregnancy, affects up to 1 in 6 pregnant women worldwide and carries risks for both mother and child. …
Cardiometabolic disease (CMD) consists of several modifiable risk factors such as diabetes, obesity and lipids that can lead to a heart attack or stroke and accounts for the majority of deaths in Nor…
We live in a 24-hour world where our daily activities are organized around the day-night cycle. Many of us wake up, eat our meals, go to work, and sleep at approximately the same time every day. Our …
PI: Thompson, Peter
Type 1 Diabetes (T1D) is a disease that results when the immune system mistakenly destroys most of the insulin-producing beta cells in the body. Insulin is required for our bodies to use energy and d…
Gestational diabetes mellitus (GDM), defined as high blood sugar that is first recognized during pregnancy, affects up to 1 in 6 pregnant women worldwide and carries risks for both mother and child. …
PI: McGuire, John J
A healthy circulation is essential to good health and depends on the functioning of blood vessels, especially the endothelial cells lining the inside of the vessels. Preventive therapies such as diet…
PI: Shakiba, Nika; Goyal, Sidhartha
Human pluripotent stem cells (hPSCs) have the special ability to "expand" - make copies of themselves - and give rise to all cell types of the body. Since their discovery over 20 years ago, hPSCs hav…
PI: World Health Organization, .
In December 2016, the Canadian Institutes of Health Research (CIHR) and the World Health Organization (WHO) jointly convened a meeting of research teams from Canada, China, India and South Africa in …
The Impacts of Empagliflozin Treatment on Angiogenesis in Skeletal Muscle of Type 1 Diabetic Rats
PI: El-Zahed, Maya
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PI: Herzog, Walter
Obesity is associated with an increased risk for cardiovascular diseases, diabetes, and metabolic syndrome. Recently, we discovered that obesity is also associated with muscle, bone, and joint degene…
PI: Light, Peter E
In Canada it is estimated that 1 in 60 individuals live with heart failure (HF) and rates are increasing. Importantly, HF patients have poor quality of life and are 6X more likely to die prematurely,…
PI: Mathews, Maria; Harris, Stewart B; Hedden, Lindsay K
The Primary Care Diabetes Support Program (PCDSP) in London, Ontario is an inter-disciplinary, team-based, primary care practice that cares for people with diabetes whose care is made more complex be…
PI: Santamaria, Pere
Type 1 diabetes (T1D) results from immune dysregulation (autoimmunity) leading to destruction of the insulin-producing cells of the pancreas (beta cells) by killer white blood cells. Susceptibility a…
PI: Santamaria, Pere
A few years ago, we discovered a new class of drugs, based on the use of tiny particles about a billion times smaller than a golf ball (a nanomedicine), that can treat diseases caused by mis-directed…
PI: Moore, Sarah A; Ball, Geoff D; Patton, Ian T
We are part of the Obesity Canada team developing the Canadian Clinical Practice Guideline for Managing Pediatric Obesity. Over the last 3 years we have worked together to summarize the best practice…
PI: Li, Patricia T; Banerjee, Ananya T; Cherisma, Aniel; Dhalla, Irfan; Elamin, Sara; Hanley, Jill; Hui, Charles; Suleman, Shazeen
Children and Youth with Special Healthcare Needs (CYSHCN) are those who have or are at increased risk for a chronic condition such as asthma, diabetes, sickle cell, and autism. They require many serv…
PI: Rebic, Nevena
HEALTH PROBLEM: Even though transgender and gender diverse people are more likely to have poorer mental and physical health, they face more barriers to getting the care they need. Likewise, the lack …
Exploring health vulnerabilities to climate change: a participatory approach to research design
PI: Harrison, Mark; Apantaku, Glory O
In Canada, there is limited investment in policies that respond to the realities of a changing climate and its effect on population health. Given the direct and indirect effects of climate change tha…
PI: Qureshi, Danial
Background: The global prevalence of dementia is rapidly increasing. There is evidence that cardiometabolic and vascular risk factors (CmVRFs) - such as diabetes, obesity, hypertension and high chole…
PI: Affoo, Rebecca H
Oral health is a vital component of health and well-being. The consequences of poor oral health extend far beyond the mouth and include reduced quality of life, malnutrition, and the development of s…
PI: Kandasamy, Sujane; Anand, Sonia S; Kwan, Matthew
There are systemic barriers preventing children and youth from low income communities--particularly new immigrant and refugee families--from accessing and participating in activities and programs tha…
PI: Ray, Joel G
Austism spectrum disorder (ASD) affects 1 in 60 Canadian children. ASD manifests as challenges in social interaction, speech and nonverbal communication, often with restricted and repetitive behaviou…
PI: Egan, Rylan G; McGarity-Shipley, Ellen
Social determinants of health (SDHs) are important social factors that affect health and include social support, housing, consistent access to food, a living income, transportation, and more. Despite…
PI: Wu, Che-Yuan
Dementia and cerebrovascular disease can lead to significant impact on everyday activities. The risk of dementia and cerebrovascular disease are linked to several chronic medical conditions emerging …
PI: Rampersaud, Y. Raja; Groe, Silvana
Background: Low back pain (LBP) is the most common cause of chronic pain and disability around the world. Access to evidence-based LBP care from providers that work together and put the patient at th…
PI: Becker, Sara
Approximately 3-4% of adults over the age of 50 suffer from symptoms of attention-deficit/hyperactivity disorder (ADHD). Often, these symptoms present as cognitive deficits such as executive dysfunct…
Obesity is defined as the excessive accumulation of white adipose tissue and is the most important risk factor for the development of insulin resistance, type 2 diabetes, dyslipidemia, liver diseases…
PI: Koné Péfoyo, Anna J; Joseph, Serena M; Ray, Lana
The increasing burden of multimorbidity (MMB) has revealed challenges of the health system to adequately manage persons with ongoing care needs for chronic diseases (CD). CD and moreso MMB require re…
PI: Dasgupta, Kaberi
Diabetes is an 'ambulatory care sensitive condition' because better clinic follow-up lowers the chances of needing to be hospitalized or of dying. People with lower incomes generally have more diffic…
The Wider Impact of the COVID-19 Pandemic on Gestational Diabetes Screening, Diagnosis, and Outcomes
PI: Yamamoto, Jennifer; Donovan, Lois E; Feig, Denice S
Gestational diabetes is one of the most common medical problems in pregnancy. It occurs when there are high blood sugar levels late in pregnancy. Gestational diabetes requires treatment during pregna…
PI: Ji, Catherine; Tu, Karen; Wilson, Sarah
Vaccines are one of the most important public health interventions to protect at-risk patients, such as children and older adults with comorbidities, from serious infections. The COVID-19 pandemic ha…
PI: Russell, James A
Bacterial community-acquired pneumonia (CAP) is a common complication of chronic heart, kidney, lung diseases and diabetes. During the COVID-19 pandemic (2020-present), changes to health care access …
PI: Yu, Amy Ying Xin; Kamal, Noreen R
Every 9 minutes, someone in Canada experiences a stroke. Stroke is the third most common cause of death among Canadians. The COVID19 pandemic has affected stroke care in many ways. First, infection w…
PI: Howard, Michelle I; Mangin, Derelie
Family doctors and teams in primary care provide the majority of care for chronic diseases. The COVID-19 pandemic has interrupted routine primary care. It is important that people with one or more ch…
PI: Lam, Tony K
The hallmark feature of obesity-associated type 2 diabetes is elevated blood glucose levels and body weight. The gastrointestinal tract regulates glucose levels, food intake and body weight in rodent…
PI: Shulman, Rayzel; Laur, Celia
Diabetic ketoacidosis (DKA) is a preventable and life-threatening complication of diabetes. DKA can be prevented if the symptoms of diabetes are recognized early, and children receive urgent and appr…
PI: McGavock, Jonathan M; Baker, Christopher; Smith, Brendan
Type 2 diabetes is a leading cause of death and disability in Canada. To date, the majority of the proposed solutions for reducing the burden of type 2 diabetes in Canada focus on "individualized" in…