CIHR Projects
Browse 2220 CIHR-funded research projects
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Showing 101-150 of 2220 projects
PI: Snowden-Richardson, Taylor M
One hundred and forty-four thousand Canadians suffer a diagnosed concussion each year. A concussion is a type of mild traumatic brain injury, often caused by a bump to the head or body that causes on…
PI: Yoshida, Kaya
One in 5 adults over age 55 suffers a stroke, the leading neurological impairment that leads to walking disability in older adults. Post-stroke, the most commonly reported goal is to return to indepe…
Olfaction in subjective cognitive decline: a candidate for early detection of Alzheimer's disease?
PI: Jobin, Benoît
The diagnosis of Alzheimer's disease is currently made when the criteria for dementia are met, i.e. when the cognitive deficits are severe enough to interfere with the person's autonomy. Thus, it is …
PI: Smith, Eric E; Badhwar, Amanpreet; Mazerolle, Erin L; Stefanovic, Bojana
More than 400,000 Canadians are living with dementia; two thirds of them are women and many come from vulnerable portions of our society including Indigenous communities and persons with lower socioe…
PI: Mihailidis, Alex; Bier, Nathalie; Choukou, Mohamed-Amine; Freeman, Shannon L; Hadjistavropoulos, Thomas; Kobayashi, Karen M; Stern, Bianca; Sveistrup, Heidi; Tamblyn, Robyn M; Warner, Grace; Yadollahi, Azadeh
Digital health technologies and services can play a critical role in enabling older adults to extend their ability to age-in-place by reducing the burden on our health systems, while also stimulating…
PI: Wu, Che-Yuan
Dementia is a major challenge for individuals, families, and the health care system. It is frustrating that effective treatment options are lacking. This necessitates the development of effective pre…
PI: Reppas-Rindlisbacher, Christina
Older Canadians represent over 40% of hospital admissions and are at increased risk of experiencing hospital related harms. One of these harms is delirium, which is a syndrome of new confusion that i…
PI: Xiong, Lisa
Alzheimer's disease (AD) and cardiovascular disease (CVD) affect many elderly people and are among the top 10 leading causes of death among Canadians. AD affects the brain and causes dementia, a cond…
Older adults are predisposed to suffering life-altering complications after surgery and strategies to mitigate these risks have shown inconsistent results. Part of the problem lies in that surgeons l…
PI: Monyror, John G
Huntington's disease (HD) is a hereditary and currently incurable neurodegenerative disease that is caused by accumulation of a toxic protein called mutant huntingtin in neurons. Gangliosides are lip…
PI: Kung, Tiffany F
Intracerebral hemorrhage (ICH) is a devastating bleed in the brain. The space occupied by the bleed (hematoma) and the accompanying swelling of the brain can increase pressure in the skull, with pote…
Older adults are predisposed to suffering life-altering complications after surgery and strategies to mitigate these risks have shown inconsistent results. Part of the problem lies in that surgeons l…
PI: Reppas-Rindlisbacher, Christina
Older Canadians represent over 40% of hospital admissions and are at increased risk of experiencing hospital related harms. One of these harms is delirium, a severe neuropsychiatric syndrome characte…
PI: Schlenker, Matthew; El-Defrawy, Sherif R
Cataracts are the leading cause of blindness and vision loss, affecting 95 million people globally and 2.5 million Canadians. They primarily affect the elderly and can impede their ability to perform…
Nurse Practitioner/Physician Collaborative Models of Care: Advancing Our Understanding of What Works
PI: McGilton, Katherine S; Dobell, Louisa G
As the long-term care (LTC) sector is moving towards recovery after the COVID-19 pandemic, it is time to address exposed gaps. Current models of care limit timely access to primary care providers, wh…
PI: Havaei, Farinaz; Keselman, David
COVID-19 has exacerbated work overload in a female dominant and racialized sector, long term care (LTC). Heavy workloads are attributed to persistent workforce challenges in LTC, such as inadequate s…
PI: Gibb, James K
About one million people in Canada identify as a member of the Lesbian, Gay, Bisexual, Transgender, Queer (LGBTQ+) community, however, recent data from Statistics Canada indicates that discrimination…
PI: Boyd, Rachel J
Parkinson disease (PD) follows Alzheimer disease as the second most common neurodegenerative disease in Canada and affects over 10 million people worldwide. PD is characterized by a loss of neurons i…
PI: Salma, Jordana M; Jones, Catherine A; Salami, Bukola O
The COVID-19 pandemic amplified the vulnerability of older adults due to health risks, increased isolation, and difficulties accessing essential services. Racialized older women from Muslim communiti…
We will look at health in a novel way by identifying body processes that are under tight control and finding genes and genetic variants that affect that control. Body processes that are tightly contr…
PI: Rosa-Neto, Pedro
Alzheimer's disease (AD) is an irreversible, progressive brain condition that affects memory and intellectual skills. People suffering from AD eventually lose their autonomy and are not able to carry…
ITCH: Itch is a debilitating symptom experienced by 40% of the elderly. Itch can have severe impact on quality of life, cause extreme stress and depression, and is the most common skin complaint in t…
PI: LanctĂ´t, Krista L; Hamani, Clement
Apathy is a common, early, and disabling symptom in dementias such as Alzheimer's disease (AD) and is characterized by reduced self-initiated behavior. Attempts to treat apathy include methylphenidat…
PI: Prado, Marco A
Alzheimer's disease is thought to be caused by abnormal accumulation of amyloid beta proteins in the brain, which lead to neurodegeneration and dementia. However, most people over the age of 70 have …
Prevalence and Impact of Fractures Associated with Spinal Cord Injuries: A population-based study
Spinal cord injuries cause life-altering changes in a persons' life, that can even go beyond the loss of movement of their limbs. People with spinal cord injuries are living longer, but because they …
PI: Hughes, Colleen
Alzheimer's disease affects the brain years, if not decades, before symptoms emerge. As such, we want to find factors that reduce later symptom severity. Here, we will investigate reduced sociality a…
PI: Brassard, Didier
In 2019, Health Canada updated Canada's food guide (CFG). Changes to CFG have been well received by the public and healthcare professionals. However, concerns have been raised. On the one hand, the n…
Frontotemporal dementia is among the most common causes of young onset dementia, with a prevalence approaching that of Alzheimer's disease in those under age 65. Severe behavioral and/or language dis…
PI: Tumati, Shankar
Poor blood flow to the brain results in cognitive deficits and increases the risk of developing dementia. Such deficits, especially in the early stages, may be reversed by improving blood flow to the…
PI: Lee, Justin Q
Every day we learn and remember how to navigate complex environments for our survival. To do so, the brain must represent the world in a behaviorally-relevant manner across the lifespan, such as the …
In dementia, brain cells that secrete an important chemical messenger named acetylcholine malfunction. Acetylcholine is a well-known neurotransmitter that regulates many brain processes, including at…
Avec le vieillissement de la population au Canada, un nombre grandissant de personnes âgées souffrent de problèmes de mémoire sévères comme la maladie d'Alzheimer. Ces problèmes de mémoire pourraient…
PI: O'Brien, Myles
The Canadian population is shifting, with a growing proportion of people over the age of 65. As people age, they are more likely to develop health problems. However, not everyone ages in the same way…
PI: Savard, Jacinthe
Les francophones vivant dans des communautés où l'anglais est la langue majoritaire ont souvent des difficultés à avoir des services de santé dans leur langue, une situation qui peut apporter plusieu…
PI: Novek, Sheila B
The devastating impact of COVID-19 on older adults in long-term care (LTC) facilities across Canada has drawn public attention to systemic problems across the sector. As governments, researchers and …
PI: Siméon, Frantz
Ce projet est une exploration de l'existant en matière de soutien à domicile à destination des proches-aidants francophones en contexte minoritaire dans le nord de l'Ontario de manière à dégager des …
PI: Meade, Robert D
Canadian summers are getting hotter, and heatwaves are becoming more frequent. During heatwaves, elderly individuals are at increased risk of adverse health events such as fatigue, adverse cardiovasc…
PI: Mekari, Said; Sénéchal, Martin
Compared to Anglophones, more Francophones living in NB are over 65 years, present low levels of education, are considered physically inactivity, have a low socio-economic status, and have poor acces…
Alzheimer's disease (AD) is a debilitating degenerative condition common among the elderly that affects 50 million people world-wide, including over 500,000 in Canada alone. AD patients first lose th…
PI: Germann, Jurgen
Deep brain stimulation (DBS) utilizes a surgically implanted medical device, similar to a cardiac pacemaker, to send electrical signals to specific brain areas. These electric pulses alter local brai…
PI: Zovoilis, Athanasios; Mohajerani, Majid
Alzheimer's disease (AD) is a disorder that results in degeneration of the brain, which leads to severe memory impairments. The most common form of the disease occurs in individuals older than 65 yea…
PI: Rochon, Paula A; Hillmer, Michael
Prescribing cascades occur when a drug is prescribed, a provider misinterprets the side effect as a new medical condition, and a second drug is prescribed to treat that condition. Based on our resear…
PI: Finger, Elizabeth; Ducharme, Simon
Frontotemporal dementia (FTD) is a devastating progressive neurodegenerative disease that is highly heritable and currently incurable. Approximately 40% of patients have a positive family history, an…
PI: Tandon, Anurag
Alpha-Synuclein (a-syn) is a key factor in Parkinson's disease (PD) and other neurodegenerative disorders known collectively as synucleinopathies. The main pathology common to these brain disorders i…
Social connectedness is important for promoting healthy aging among Canadians. In particular, measures of social connectedness such as marital status are linked to greater survival and less chronic d…
PI: Novak, Alison
Bathroom navigation is an essential skill for independent self-care. However, bathroom design components, such as slippery floors, amplify mobility challenges for older adults and those with mobility…
PI: Eng, Janice J
BACKGROUND: Stroke is common with a 1 in 4 lifetime risk of stroke after age 25. One of the most sought after goals by people with stroke is improved mobility. Since the COVID-19 pandemic, many hospi…
PI: Johnsrude, Ingrid S; Herrmann, Björn; Scollie, Susan D
Approximately two in five individuals over 60 experience difficulty understanding speech with even mild background noise. Clinical diagnosis of hearing impairment, and remediation with hearing aids, …
PI: Kim, Eric
In Canada, life expectancy has stagnated, and years lost to disability have increased. Further, healthcare spending, which reached $264.4 billion in 2019, is projected to continue escalating. This is…
While eye drops are a cornerstone of eye care, they suffer from serious limitations. In current formulations, the tears quickly flush the drugs from the surface of the eye, thus requiring frequent, s…