CIHR Projects
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PI: Sirbu, Olga I
Medulloblastoma is the most common cancerous brain tumour in children-one out of five childhood brain tumours are medulloblastoma. While the majority of ill health and death occurs due to metastasis,…
Pancreatic cancer is a lethal disease that typically presents at the advanced or metastatic stage. Chemotherapy remains the mainstay of treatment, but finding a targeted therapy has been a challenge …
PI: Lamarche, Jani
Fear of cancer recurrence (FCR) is common, persistent, and is associated with negative physical and mental health outcomes. Family caregivers (FC) of cancer patients experience equal or greater level…
Arsenic is an established carcinogen for the skin, bladder and lungs; however, the impact of arsenic exposure on cancer risk at other sites, including the breast, remains inconclusive. Recently, our …
PI: Shapovalov, Ivan
Metastatic cancer spread is the cause of poor prognosis in cancer. Canadian statistics show that patients with non-metastatic breast cancer have a 90% 3-year survival chance, but patients with metast…
Regardless of mutational origin, in all cancers, cells must change their biophysical characteristics to migrate through fibrous multicellular environments. As such, cell softening and increased cell-…
PI: Fukano, Marina
Breast cancer is the most diagnosed and second deadliest cancer among women in Canada after lung cancer. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks known breast can…
PI: Heney, Kayla
Melanoma is the deadliest form of skin cancer, arising from the cancerous transformation of the melanocytes, the pigment producing cells of the skin. In 5-10% of sun-exposed melanoma patients, a recu…
Immune checkpoint inhibitors are a type of cancer therapy that targets your immune system's natural ability to fight cancer. This treatment has been revolutionary for lung cancer, which is often diag…
Evaluating a chemokine signature as a predictive biomarker for T cell-inflamed cancer subtypes
Pancreatic cancer is the 3rd leading cause of cancer deaths, with less than 10% of patients surviving this cancer. An important reason for this lethality is that pancreatic cancer does not respond we…
PI: Ferrier, Sarah T
Head and neck cancer includes cancers of the mouth, tonsils, throat, and voice box. It can be caused by smoking and drinking, but also by infection with a virus called Human Papillomavirus (HPV). Whi…
PI: Lagace, Francois
Background: Cutaneous melanoma (CM) causes more deaths than any other skin cancer. In Canada, CM is the 8th most commonly diagnosed cancer and the number of CM cases is increasing. There are many wel…
PI: Valic, Michael S
The development of nanoparticles for personalised anti-cancer medicine has reached a breakneck pace in papers published and patents submitted. However, few of these nanoparticle candidates will survi…
PI: Liu, Zhe Qi
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and has the lowest 5-year patient survival rate of all major cancer types. Immunotherapy is an increasingly promis…
Unraveling the role of stress granules for leukemia stem cell maintenance and stress adaptation
PI: Tajik, Amanda
Acute myeloid leukemia is an aggressive form of blood cancer. Although remission after initial treatment is common, for many patients the disease returns, oftentimes in a more aggressive and treatmen…
PI: MacDonald, Kate
When our cells are exposed to DNA-damaging agents, such as UV light from the sun or the chemotherapeutic drugs commonly used for cancer treatment, pieces of DNA can break off from our chromosomes. Th…
PI: Harb, Sami I
To help manage the biopsychosocial consequences of cancer, many patients receive care from informal caregivers who are unpaid family members or friends. But with the onset of COVID-19, caregivers are…
PI: Vanstone, Ruth N
Although survival rates after cancer diagnosis and treatment continue to rise, the experience of cancer can pose challenges well into survivorship. Women of childbearing age who are diagnosed with ca…
PI: Panichnantakul, Pudchalaluck
The preservation of genetic material is essential for cell proliferation and survival. Unstable or damaged DNA can result in mutations and subsequently contribute to diseases which include a multitud…
PI: Lee, Stacey N
Natural Killer (NK) cells are cells of the immune system that can identify and kill unhealthy cells by using markers that label cells as healthy or unhealthy. Cancer cells are good at using certain m…
PI: MacLean, Leah K
Lung cancer is the most common cause of cancer death worldwide and Nova Scotia demonstrates the highest incidence rate of all Canadian provinces. Most lung cancer patients have a subtype that falls u…
PI: Kapcan, Eden
The immune system is trained at recognizing and killing dangerous objects in your body. These dangerous objects could be bacteria, viruses, or cancer. Sometimes cancer is able to evade the immune sys…
PI: CHEN, HE TIAN
Leukemias originate from the accumulation of mutations within hematopoietic stem cells, which are responsible for replenishing blood and immune cells for the body. Mild, pre-leukemic mutations in the…
PI: Portillo, Ana
Breast cancer is the most common cancer affecting women worldwide. Triple negative breast cancer (TNBC) accounts for 12-15% of cases, and is the most aggressive form of breast cancer with the highest…
Colorectal cancer (CRC) is the second most common cancer in Canada and is the second and third leading cause of cancer-related death among men and women, respectively. New cases of CRC are declining …
Background: Approximately 300,000 children are diagnosed with cancer annually. Treatments result in significant negative side effects. Physical activity (PA) is safe, beneficial, and feasible for chi…
PI: Daun, Julia T
Individuals with brain cancer lack access to an exercise oncology program that can address their unique physical and psychological needs. The Alberta Cancer Exercise - Neuro-Oncology (ACE-Neuro) stud…
PI: Charron, Jeremie
Il est bien connu maintenant que la pratique régulière d'activité physique permet de diminuer considérablement le risque de développer plusieurs cancers, mais on en sait très peu sur son efficacité c…
PI: Ng, Deanna
Gastric adenocarcinoma (GCa) is one of the leading causes of cancer death globally. One of the distinguishing features of GCa is its propensity to spread into the peritoneal layer of the abdominal ca…
PI: Lin, Chien-feng
Cancer is a leading cause of death worldwide across all demographics. In cancer, there is a "loss of control" (i.e., dysregulation) of genes essential for regulating cell growth. MYC is a protein tha…
Li-Fraumeni Syndrome (LFS) is a genetic condition which drastically increases the risk of developing a spectrum of early-onset cancers. 1 in 5000 people are affected by LFS, and 80% of LFS patients a…
PI: Choi, Woo Jin
Intrahepatic cholangiocarcinoma (iCCA) is a type of bile duct cancer located inside the liver. iCCA is the second most common cause of liver cancers and only 10% of those who are diagnosed with this …
PI: Chow, Jonathan T
As of 2019, 1 in 9 Canadian men are estimated to be diagnosed with prostate cancer (PCa) in their lifetime, which represents the most common cancer diagnosis in Canadian men and fourth most common ca…
Every year, there are about 20 million new cancer cases and about 10 million cancer deaths. This devastating disease, which is caused by mutation and abnormal proliferation of cells, often leads to t…
PI: Iqbal, Javaid
The COVID-19 pandemic has provided a test of whether the Canadian health care system can accommodate a health crisis and continue to deliver equitable, high-quality end-of-life cancer care. Although …
Medulloblastoma is the most common malignant paediatric brain tumour and is currently treated with surgery, external beam radiation and chemotherapy. Current treatments are debilitating to the develo…
Traditional therapeutic cancer vaccine approaches typically involve injecting cancer patients with antigens (molecules that can trigger an immune response) specific to their own tumors, along with im…
People diagnosed with cancer who are Two-Spirit, lesbian, gay, bisexual, transgender, or queer (2SLGBTQ+) often experience cancer differently from their counterparts who are cisgender and/or heterose…
PI: Voisin, Mathew
Gliomas represent the vast majority of malignant brain tumors and include a diverse range of pathologies that all share one common feature: they are incurable. When gliomas recur after treatment, the…
PI: Klassen, Pamela
Inoperable pancreatic cancer (IPC) is a terminal diagnosis with distressing symptoms including diarrhea, bloating and weight loss. Pancreatic tumors block the path of digestive enzymes, causing poor …
PI: Teng, Katie
Many healthy adult tissues, such as the breast and skin, contain cells that carry mutations that accumulate with age and are linked to cancer development. Although many cells are known to be mutated …
PI: Jamalkhah Choshali, Monire
Breast Cancer is the second most common cancer in Canada and the most common cancer among Canadian females. Poly(ADP-ribose) polymerase inhibitors have been approved by Food and Drug Administration f…
Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain tumour, with patients having a median survival rate of fewer than 15 months. Moreover, the first-line approved ther…
Hematopoietic Stem Cell Transplantation (HSCT), the infusion of a donors immune system into a recipient, is an important immune-based therapy for patients with high-risk and recurring blood cancers. …
PI: Voisin, Mathew
Gliomas represent the vast majority of malignant brain tumors and include a diverse range of pathologies that all share one common feature: they are incurable. When gliomas recur after treatment, the…
PI: Sorin, Mark
Lung cancer is the greatest cause of cancer-related death worldwide, accounting for about 25% of all cancer-related fatalities. Indeed, more people die from lung cancer than breast, colon and pancrea…
Evaluating a chemokine signature as a predictive biomarker for T cell-inflamed cancer subtypes
Pancreatic cancer is the 3rd leading cause of cancer deaths, with less than 10% of patients surviving this cancer. An important reason for this lethality is that pancreatic cancer does not respond we…
PI: Kong, Tim
Myeloproliferative neoplasms (MPNs) are a group of blood cancers/leukemias in which there is overproduction of one or more types of blood cells and affect ~5/100,000 persons. Polycythemia vera and es…
PI: Wong, Alan Y
Leukemia is the most common childhood cancer and the second greatest cause of pediatric cancer mortality in Canada. Chemotherapy directed to the central nervous system (CNS) is a critical part of tre…
PI: Haddad, Elie
Rhabdomyosarcoma (RMS) is the most common soft tissue cancer in childhood. Although progress in treatments have led to a remission rate of approximatively 60% of all pediatric cases, the prognosis of…