CIHR Projects
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PI: Vernon, Julia
The prevalence of mental health problems in Canadian youth has surged in the past decade, making youth mental health an urgent public health priority. Secure youth-parent relationships buffer teens f…
PI: Dionne, Olivier
Le syndrome du X fragile (SXF) représente la cause héréditaire la plus fréquente de déficience intellectuelle et de troubles du spectre autistique. Les individus avec SXF sont également sujets à un v…
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication difficulties and restricted/repetitive behaviours and interests. There has been substantial diffi…
PI: Samuel, Susan M; Andrade, Brendan; Archibald, Mandy M; Benchimol, Eric I; Birken, Catherine S; Chafe, Roger E; Chaillet, Nils; Jans, Jop; Keijzer, Richard; King, Alexandra; King, Malcolm; Mandhane, Piush; Poonai, Naveen; Pritchard-Wiart, Lesley; Regnault, Timothy R; Salami, Bukola O; Stinson, Jennifer N; Tersigni, Claudia A; Thomson, Ron; Walsh, Catharine M; Zwicker, Jill G
Children and youth are the promise for a bright future for Canada. Despite this, Canada ranks 30th of 38 affluent nations in indicators of child health and well-being. Therefore, researchers working …
PI: BĂ©rard, Anick; Boucoiran, Isabelle; Carleton, Bruce C; Eltonsy, Sherif; Giros, Bruno J; Hanley, Gillian E; Hawken, Steven; Kaul, Padmaja R; Lacasse, AnaĂŻs; Lanovaz, Marc J; Mehrabadi, Azar; Oberlander, Timothy F; Pilote, Louise; Vinet, Evelyne; Walker, Mark C; Winn, Louise M; Winquist, Brandace D
At present, no academic or ad-hoc programs give the required comprehensive and standardized perinatal epidemiology/pharmacoepidemiology, pharmacogenomics and toxicology training combined with adequat…
PI: Letourneau, Nicole L; Darroch, Francine E; Jackson, Margaret A; Jaffe, Peter G; Leason, Jennifer L; Lessard, Geneviève; Nixon, Kendra L; Rickards, Tracey; Ross, Kharah M; Scott, Katreena L; Stewart-Tufescu, Ashley; Wood, Karen E
Adverse childhood experiences (ACEs), most notably family violence and maltreatment, disproportionally affect girls and women. Females who are Black, Indigenous or People of Colour (BIPOC) may be eve…
Intestinal failure (IF) is a devastating condition resulting in long-term parenteral nutrition support (nutrition through an intravenous line). Pediatric IF leads to significant costs to the healthca…
PI: Fung, Alastair
In low- and middle-income countries (LMICs), current World Health Organization (WHO) guidelines recommend routine home visits by community health workers to assess infants and urgently refer to hospi…
L'entraînement aux habiletés en fauteuil roulant (EHFR) permet aux enfants présentant une incapacité physique de se déplacer de façon autonome et sécuritaire dans leur communauté. Cela favorise leur …
PI: Nagaraj, Sujay
Li-Fraumeni Syndrome (LFS) is a rare genetic condition that increases an individual's risk of developing cancer. By age 20, patients with LFS have a 40% of developing cancer and >90% chance by age 70…
Past traumatic events can leave lasting negative impacts on parents that may, in turn, negatively affect their children's health and development. This link is a complex situation not understood or ad…
PI: PATTON, MICHAELA
BACKGROUND: Over 30,000 childhood cancer survivors live in Canada today, but two-thirds will experience long-term side-effects of their toxic treatments, like chronic pain. This is concerning because…
PI: Smith, Jackson
Children who have experienced multiple types or repeated exposures to interpersonal victimization in the context of a caregiving relationship (i.e., developmental trauma) exhibit a wide range of neur…
PI: Samaan, M. Constantine; Thabane, Lehana
Around 5400 children in North America are diagnosed with brain tumors every year, making them the most common solid tumors in children. The good news is that advances in cancer care have dramatically…
PI: Gill, Peter J; Li, Patricia T; Mahant, Sanjay; To, Teresa
Hospital care consumes the largest component of healthcare costs in Canada. Despite the high costs, there is a lack of high-quality research evidence on the diagnosis and treatment of hospitalized ch…
PI: Andrade, Brendan
Children who are aggressive, oppositional and defiant (i.e., disruptive behavior) represent 5-15% of school-aged children and a majority of those referred to children's mental health centers. Best pr…
PI: Yong, Paul; Anglesio, Michael S; Howard, Amanda F; Mohamed, Ali Bedaiwy; Talhouk, Aline
Endometriosis affects ~1 million individuals in Canada. It is defined as tissue, which resembles tissue from inside the uterus (womb), growing outside of the uterus in other parts of the body. Endome…
Preterm birth before 37 weeks of the typical 40 weeks of pregnancy is a major stress on both the infant and their mother. Especially for infants born very prematurely at less than 33 weeks of complet…
"Terrible twos" is a well-known idiom and for good reasons; children start exploring their environment, occasionally in a perilous manner, and have tantrums and anger outbursts when frustrated. In re…
Previous pandemics and seasonal influenza studies have shown that in utero exposure to maternal viral infection results in a 2-7-fold increase in neurodevelopmental and neuropsychiatric disorders in …
Unhealthy food and beverage marketing negatively impacts the food preferences, dietary habits and health of young people, yet little is known about the power and exposure of such marketing to teenage…
Retinopathy of prematurity is one of the leading causes of blindness in children. Loss of blood vessels in the immature retina of premature infants decreases energy delivery to neurons, leading to vi…
PI: Zwicker, Jill G
Developmental coordination disorder (DCD) is a common condition that affects 5-6% of school-aged children, or 1-2 children in every Canadian classroom. Children with DCD find it hard to learn motor s…
PI: Ray, Joel G
Women with diabetes mellitus before pregnancy are thought to be at a higher risk of miscarriage, stillbirth and need for abortion; their newborns are at higher risk of dying or having a birth defect …
PI: Poletto Bonetto, JĂ©ssica H
In Canada, 8% of births are premature (less than 37 weeks of pregnancy). Thanks to medical advances over the past 30 years, most premature babies now survive, and the first generations of very premat…
Maternal education and offspring mental health in adulthood : Identifying the mediating pathways
PI: Loose, Tianna T
Children living in disadvantaged socioeconomic contexts are at greater risk of developing mental health problems in adulthood. This project examines the role of maternal education -a key determinant …
PI: PALMIS, Sarah W
Every year in Canada, more than 25000 infants are born prematurely (inferior to 37 weeks of gestation). These infants will subsequently be very at risk to develop neurodevelopmental disorders (NDD) r…
PI: Scime, Natalie V
Autoimmune diseases are chronic immune-mediated conditions that are up to 9 times more common in females compared to males, and are a leading source of disability and premature death in women. Knowle…
PI: Pituch, Evelina
Despite increased pregnancy rates among women with physical, sensory, and intellectual and developmental disabilities (WWD), barriers to perinatal services are reported in high-income countries like …
Testing the effects of two parenting programs on dynamic parental emotion regulation processes
PI: Zhang, Xutong
In addition to teaching parents skills to effectively manage children's behaviors, parenting-focused prevention programs have started to also target parents' regulation of their own emotions, which i…
Chronic pain affects one in five youth and is associated with high societal and economic costs. As many youth with chronic pain do not receive a diagnosis that precisely explains a pathological cause…
PI: Goulter, Natalie
Children and adolescents are particularly sensitive to developing externalizing (EXT; attention-deficit/hyperactivity, oppositional, conduct symptoms) and internalizing (INT; anxiety, depressive, pho…
Creation of an Arts-Based Knowledge Translation Tool about Pediatric Heart Failure for Parents
Having a child diagnosed with heart failure (HF) is a distressing and terrifying experience for parents. HF is a condition where the heart is unable to pump enough blood to the body, leading to many …
PI: Dol, Justine
Poor mental health among women puts children at risk for poor developmental outcomes. However, poor mental health in fathers is just as important yet remains understudied. Most postpartum interventio…
The rate of preterm birth in Canada is 8% with 1 in 12 infants being born too soon. Preterm infants are at risk for brain injury which can lead to motor impairment and cerebral palsy. In addition, ch…
PI: Park, Joanne
Introduction: All families experience some form of stress and strain in their lives, and parents are tasked with the important role of facilitating their child's development amid these stressors. Exe…
Children's healthy development is very sensitive to exposure to environmental chemicals during pregnancy. Prenatal exposure to plastic chemicals, including bisphenol A (BPA) and phthalates, is unavoi…
When diagnosing common mental health conditions like anxiety, depression, substance use or self-harm, or when evaluating treatments in youth aged 14-24 years, clinicians must consider both the severi…
PI: Amed, Shazhan; Nakhla, Meranda; Von Oettingen, Julia E; Zenlea, Ian S
Diabetes in one of the most common lifelong childhood disorders that affects ~40,000 children and youth in Canada. Research shows that even with new technology and drugs, children and youth living wi…
PI: Ahun, Marilyn
The early childhood environment (i.e., from conception to age 5 years) is crucial for healthy child development. Children's mental development - that is the cognitive, language, and socioemotional sk…
PI: Shen, Garry X; Decaire, Elizabeth; Omarr, Vivian L
COVID-19 pandemic seriously affected the prenatal education for pregnant women and potentially has long lasting adverse effects on the pregnancy outcome and health of mothers and their children. Firs…
PI: Aita, Marilyn; Heon, Marjolaine
À l'unité des soins intensifs, les bébés prématurés peuvent être exposés à des stimulations négatives, comme un éclairage et du bruit intenses, et avoir des contacts limités avec leur mère. Ces expér…
PI: Lye, Stephen J
There is currently no effective therapy to prevent the birth of the 13 million babies born preterm (PTB) each year. Importantly, we have shown that labour is preceded by an influx of maternal white b…
PI: Brian, Jessica A
This project uses a rigorous research design to evaluate an innovative early intervention program for toddlers with autism spectrum disorders (ASD). The program builds on an evidence-based in-person …
Moving freely in indoor and outdoor environments is optimal for all children's physical, social and psychological health and development. Furthermore, research suggests that movement enhances childre…
Many teenagers sleep much less than the 9 hours a night that are recommended, which puts them at risk for difficulties with mental health and school. We took input from youth and developed an interve…
Conductive hearing loss affects 4% of adults and 1.5M Canadians. It is usually caused by a fixation or discontinuity of the structures behind the eardrum that carry sound from the eardrum to the coch…
Control of placental development and pregnancy health by uterine immune cells and osteopontin
During pregnancy, an organ called the placenta burrows into the mother's uterus to make sure the baby gets the food and oxygen it needs. If the placenta burrows too deep or too shallow, dangerous pre…
In Canada, less than one third of women attend prenatal classes and in rural areas, attendance is less than 20 percent. We have developed a cell phone text messaging program (SmartMom) to deliver pre…
PI: Joussemet, Mireille; Mageau, Geneviève A
Psychological problems are common: one out of five young children live with some mental health problems. These problems can persist and negatively affect life up to adulthood. Efforts should thus be …