CIHR Projects
Browse 1992 CIHR-funded research projects
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Showing 101-150 of 1992 projects
PI: Chandran, Vinod; Kulasingam, Vathany
Psoriasis is a common chronic inflammatory skin disease that affects more than a million Canadians. Many patients with psoriasis also have involvement of the joints and develop a specific form of art…
Immunomodulatory Gene Therapy Strategies for Post-Traumatic and Metabolic Forms of Osteoarthritis
PI: Grol, Matthew W
Osteoarthritis (OA) is a disease that occurs when joint structures, including the articular cartilage that protects the ends of bones, degenerate following trauma or due to conditions such as obesity…
PI: Wang, Rizhi; Guy, Pierre
Hip fracture is a significant cause of morbidity and mortality; it happens easier in older people especially females. A question here is: what makes bone fragile as we become older? Current consensus…
PI: Drucker, Aaron M; Tadrous, Mina
Psoriasis is a chronic skin condition that can decrease quality of life substantially. It is sometimes associated with psoriatic arthritis, a debilitating joint disease. Both of these conditions are …
PI: Lacasse, AnaĂŻs
La douleur chronique touche un adulte sur cinq et a de sérieux impacts sur notre société. Malgré des décennies de recherche sur la douleur chronique et son traitement, on constate malheureusement que…
Determining the molecular mechanisms of titin's role in active force production in striated muscles
PI: Herzog, Walter
Textbooks of muscle physiology state that muscle contraction and force production are entirely accounted for by two proteins, actin and myosin. This actin and myosin-based theory was developed in the…
PI: Morin, Suzanne N; Giangregorio, Lora Marie
Osteoporosis is considered a women's disease. Yet, the burden of osteoporotic fractures in men is substantial, and men suffer significantly more complications following a fracture than women. Men who…
Painful degeneration of the spine is one of the most common disabilities in young and middleaged professionals. However, very little is known about the cause of this pain and no early treatment optio…
PI: McCulloch, Christopher A; Carneiro, Karina M
In Western societies, ~45% of deaths, including certain types of invasive cancers, heart failure, and chronic kidney disease, are associated with disorganized connective tissues and loss of their nor…
Physical forces are critical for successful function of many organs including bone. Bone is formed or removed to meet changes in the local mechanical environment. Exercise is the most efficient and c…
Predicting fragility fractures by non-invasive high-resolution imaging and advanced morphometrics
PI: Boyd, Steven K
Osteoporosis is a condition where bones become fragile and more likely to break due to a decrease in bone mineral density and concurrent structural changes, leading to decreased bone strength. Unfort…
PI: Watson, Tristan
I am an ideal candidate for the Summer in Aging (SPA) training program, because I plan on studying the effect of symptomatic osteoarthritis (OA) on depression in Canadian older adults using the Canad…
In 2016, Canada's population reached a key demographic point, when the number of Canadians 65 years and older exceeded those younger than 14 years. As the population is aging, osteoporosis, fractures…
PI: Roux, Sophie
Rheumatoid arthritis is an incredibly diverse disease. The variability observed in clinical presentation, response to treatment and clinical outcomes suggest that the mechanisms activated during the …
PI: Webster, Fiona
Canadians are currently facing unprecedented challenges with the COVID-19 pandemic. Governments and health care systems are scrambling to find ways to minimize the downstream impacts of the pandemic …
PI: Chandran, Vinod; Kulasingam, Vathany
Psoriasis is a common chronic inflammatory skin disease that affects more than a million Canadians. Many patients with psoriasis also have involvement of the joints and develop a specific form of art…
PI: Drucker, Aaron M; Tadrous, Mina
Psoriasis is a chronic skin condition that can decrease quality of life substantially. It is sometimes associated with psoriatic arthritis, a debilitating joint disease. Both of these conditions are …
Rheumatoid arthritis (RA) is one of the most prevalent chronic inflammatory disorders in North America; it currently affects about 300,000 Canadians, and costs our economy a staggering 5.8 billion pe…
PI: Gilron, Ian
Chronic pain affects 20-30% of Canadians, costs >$650 billion/year in North America and is recognized as a disease in its own right. Current therapies have limited efficacy and tolerability. Rational…
Arthritis is a collection of more than 100 debilitating diseases affecting the joints and surrounding tissues leading to progressive dysfunction of the affected joints and causing an incredible burde…
PI: Fortin, Carole
At adolescence, 2-3% of adolescents are at risk of developing an idiopathic scoliosis, which is a 3D spinal deformity affecting mostly girls with unknown cause. Scoliosis causes body deformities whic…
Oral health is of fundamental importance for humans and the two most common disorders of humans, periodontal diseases and dental caries, both localize to the oral cavity. For periodontal diseases, th…
PI: Barralet, Jake E; Makhoul, Nicholas
The bypass procedure in the heart or legs and more preferably placement of a stent to either bypass or reopen arterial blockages saves lives. The bypass consists of harvesting a nonessential vessel a…
PI: Dufour, Antoine
Rheumatoid arthritis is often diagnosed at late stage resulting in greater damage than if the diagnosis was made earlier. It commonly involves a dysregulation of disease-fighting defence proteins alo…
PI: Westover, Lindsey M; Mei, Qipei
Scoliosis is an orthopaedic condition resulting in curvature and rotation of the spine. It typically first appears during adolescence, and affects females more than males. Deformity of the torso is o…
PI: Hayes, Kaleen N
Type 2 diabetes (T2DM) is a chronic condition of high blood sugar that affects 10% of Canadians and can cause numerous complications when not managed, including major cardiovascular events like strok…
PI: Truong, Linda L
North America has the highest rates of osteoarthritis (OA) in the world. OA is a joint disease that causes pain, physical disability, and reduced quality of life. By 2040, 25% of Canadians will have …
PI: Gabel, Leigh E
Physical activity is essential for bone health. Everyday activities, like walking, dancing and other forms of exercise force our bodies to work against gravity to carry our body weight, making our sk…
The anterior cruciate ligament (ACL) is the most frequently damaged knee ligament, with rates continuing to rise among active paediatric athletes. Moreover, the risk of ACL re-injury after surgical r…
PI: Khan, Michaela C
Knee osteoarthritis is an incurable disease characterized by the breakdown of cartilage which cushions the ends of bones in your knee joint. This condition is an expensive cause of disability in Cana…
PI: Bass, Alec
Many individuals with a spinal cord injury (SCI) use a wheelchair as their primary mode of locomotion. The prolonged inactive sitting time associated with this mode of locomotion contributes to the d…
Issue: Shoulder problems affect many Canadians yearly. While surgery is one of the best treatments for shoulder problems, patients are unaware about shoulder replacement surgeries, the exercises need…
Fracturing the wrist usually requires a brace/cast to be worn for at least six weeks to keep the wrist inactive for fracture healing. The inactivity leads to loss of motor function (i.e. reduced stre…
PI: Watson, Tristan
In Canada, a major public health concern is that osteoarthritis (OA) and depression affects millions of Canadians, and both conditions co-occur in about 20% of adults. Most people know a friend or lo…
PI: Hoit, Graeme
Background: Femoroacetabular impingement syndrome (FAIS) is a painful hip condition caused by abnormal bone structure of the hip joint affecting young patients, most commonly 20-45 years old. Previou…
PI: Meas, Steven J
Over 1.5 million of Canadians are affected by osteoporosis, a disease that is caused by weak bones and leads to increased risk of fracture. As the Canadian population ages, the burden of osteoporotic…
PI: Philip, Anie; Leask, Andrew C
Scleroderma or systemic sclerosis (scleroderma) is a complex rheumatoid disease that is characterized by defective immune system function, blood vessel damage and scarring (fibrosis) of the skin and …
Development of Antisense Oligonucleotide-Based Therapy for Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common kinds of muscular dystrophy in adults. It is a genetic problem that results in slow weakening and wasting of muscle in the face…
PI: Guzman, Jaime
When arthritis strikes a child, families face tough questions. Will their child suffer? Will they outgrow arthritis? Will they respond to treatment? Will there be side effects? The answers to these q…
Nicotinic acetylcholine receptors (nAChRs) are signaling proteins that play a central role in the communication between nerves and muscle. At the neuromuscular junction, the nAChR converts the chemic…
PI: Cioffi, Iacopo; Moayedi, Massieh
Pain is the primary cause of long-term disability, and it poses the most significant health-related burden on Canadian society. Temporomandibular disorders (TMD), a set of conditions affecting the ja…
A neuropathic-like component in arthritis pain: characterization and therapeutic possibilities
Arthritis pain is a serious clinical issue in Canada. Its relief is often unsatisfactory, and it is often increased by movement. Our understanding of its mechanisms is poor, which makes developing mo…
PI: Megeney, Lynn A
Duchenne Muscular Dystrophy (DMD) is a fatal genetic disease caused by mutations in dystrophin, the largest gene in humans. This gene produces a protein called dystrophin, which is critical to mainta…
PI: Dutz, Jan P
Sunlight therapy (phototherapy) is commonly used by dermatologists to treat inflammatory skin disease. It is known that this treatment works in part in the skin by inducing the death of disease-causi…
Glucocorticoids are one of the most widely prescribed classes of drugs in both children and adults due to their potent anti-inflammatory action. However, one of the major side effects of glucocortico…
PI: Maly, Monica R
IMPORTANCE By 2041, over 10 million Canadians will have osteoarthritis (OA), with the knee most often affected. Knee OA causes long-term pain and immobility. It damages all tissues in and around a jo…
PI: Fahmi, Hassan
OA is the most common form of arthritis and a leading cause of disability in Canada and worldwide. It has a large impact on the patient's quality of life, constitutes a significant socio-economic bur…
PI: Mckee, Marc D
Bones and teeth undergo a process called mineralization where small calcium- and phosphate-containing crystals are deposited into a scaffolding of proteins called the extracellular matrix. Protein-mi…
PI: Desmeules, François; Emond, Marcel; Perreault, Kadija
Overcrowding in emergency departments (ED) is a major concern worldwide. Recent reports show that Canada has among the longest ED waiting times and patients suffering from musculoskeletal disorders (…
The oral cavity is a unique environment that combines complex bacterial biofilms, saliva and fine-balanced mechanisms of innate and cellular immunity. Numerous conditions that manifest in the oral ca…