CIHR Projects
Browse 4616 CIHR-funded research projects
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Showing 101-150 of 4616 projects
PI: Duarte, Kaue T
The population living with dementia in Canada is >500,000 and will increase significantly in the following decades. There are significant health and economic benefits associated with the early detect…
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting tens of millions of people worldwide, characterized by a gradual loss of memory and other cognitive functions. Two misfol…
PI: Wong, Yuen Yan
Alzheimer's disease (AD) is the commonest cause of dementia, in which patients experience progressive deterioration of cognitive and physical abilities. Dementia affects ~50 million people worldwide,…
PI: Simpson, Robert; Lai, Nanette; Munce, Sarah E
Background Multiple sclerosis (MS) affects >90000 Canadians and is very expensive from the Canadian health and social care perspective; 1/3 costs derive from 'hidden' symptoms such as stress. Access …
PI: Leslie, Kathleen; Bartram, Mary; Bourgeault, Ivy L
BACKGROUND: The people who provide mental health and substance use health services play a critical role in supporting Canadians. How these providers are regulated varies significantly across Canada, …
PI: Carriere, Junie S; Leonard, Guillaume M
The COVID-19 pandemic has challenged the feasibility of multisession in-person treatment options, creating the need for accessible solutions that are low-cost, low-burden, and remove the need for fac…
PI: Ostry, David J
Motor memory analogues of recognition and cued-recall testing show that there is information about previously learned movements that is available in motor memory but is not accessed using tests invol…
PI: Zaheer, Juveria; Rudoler, David
10 people die by suicide in Canada every day, and many more suffer from suicide-related thoughts and behaviours. The COVID-19 pandemic has disrupted the lives of all Canadians, and has been associate…
PI: Hatcher, Simon; Orpana, Heather M
Contrary to predictions at the start of the COVID-19 pandemic suicide rates have not increased and may have declined during the pandemic. However, some sub-populations may have had an increase in rat…
Addressing the Wider Impacts of the COVID-19 Pandemic on Mental Health and Substance Use in Canada
PI: Chaiton, Michael O; Hamilton, Hayley A; Shield, Kevin D
Mental health challenges affect all Canadians. Yet many Canadians lack access to mental health care services, with equity in access a key concern for specific groups due to gender, ethnicity, socio-e…
With the responsibility for the safety of our population, public safety personnel have been at the forefront of the COVID-19 pandemic, facing stressful and potentially traumatic situations, such as e…
PI: Wazana, Ashley; Rozenberg, Mira; Tresierra, Millie; Choudhury, Suparna
Research demonstrates that environmental adversity (stressful life events, poor housing, financial problems, domestic violence, substance abuse, single parents) and poor maternal mood are associated …
PI: Sloan, Matthew E; Buckley, Leslie
The COVID-19 pandemic has had major impacts on both alcohol use and access to alcoholism treatment. For example, roughly a quarter of Canadians report increased alcohol consumption during the pandemi…
PI: Castellanos Ryan, Natalie; Chadi, Nicholas; Seguin, Jean R
Two thirds of Canadian youth (15-25 years) are active drinkers. This is concerning considering youth drinking - and particularly, frequent, or risky drinking (consumption of >4 drinks (women) or >5 d…
PI: Chen, Shu-Ping; Harvey-Jansen, H. Z'Anne
The high incidence of heavy episodic drinking among students, and the related negative consequences on Canadian university campuses, is an ongoing concern. Problematic alcohol consumption among first…
PI: Dermody, Sarah S; Yager, Christina M; Abramovich, Alex
We know very little about alcohol use and harms experienced by transgender youth, whose gender identity differs from the sex they were assigned at birth. It is important to understand their alcohol u…
PI: Ouimet, Marie Claude; Brault, Maxime; Fafard, Fannie
Impaired driving is a significant, persistent, yet preventable contributor to alcohol-related harm. Despite the importance of prevention to reduce impaired driving, research into evidence-based pract…
PI: Corace, Kimberly M; Kahan, Meldon; Willows, Melanie; Hutton, Brian E; Thavorn, Kednapa
Alcohol use in Canada, and globally, is a leading risk factor for disease, disability, and death. The COVID-19 global pandemic has also led to an increase in alcohol consumption amongst Canadians, wi…
PI: Asbridge, Mark; Purcell, Judith Anne; Callaghan, Russell C
Alcohol is the most commonly consumed drug worldwide and is ubiquitous in most societies and cultures. The widespread consumption of alcohol, however, is associated with substantial societal harms an…
PI: Strudwick, Gillian; Lo, Brian F
The objective of this grant is to catalyze the OurNotes movement in mental health settings by engaging relevant stakeholders in planning activities to do so, and communicating the outputs of these ac…
Recognizing and responding to novelty is critical for everyday life, and many neural disorders exhibit novelty-related behavioural manifestations. As such, understanding how novelty stimuli are coded…
PI: Virji-Babul, Naznin; Babul, Shelina
Concussion or mild traumatic brain injury (mTBI) is an urgent public health concern and one of the least understood neurological injuries. Children and youths are especially vulnerable: they are disp…
PI: Stewart, Sherry H; Asbridge, Mark; Bombay, Amy; Brunelle, Caroline; Davidson, Sara; Etches, Selene; Harris, Nicholas; Hollett, Bruce; Hudson, Amanda; Yetman, Gerard F
Substance use disorder (SUD) is a major public health challenge in Canada. In 2015, CIHR funding established the 1st national network in SUD research, the Canadian Research Initiative in Substance Mi…
PI: Jutras-Aswad, Didier; de Kiewit, Alexandra; Bach, Paxton J; Bruneau, Julie; Davidson, Sara; Emerson, Yvette; Hodgins, David C; Le Foll, Bernard; Poulin, Ginette; Rehm, JĂĽrgen T; Stewart, Sherry H; Wood, Evan
Methamphetamine ("meth"; MA) use in Canada is on the rise. In the past decade, the number of deaths, hospitalizations, and emergency room visits due to MA and other stimulant use has increased across…
PI: Rehm, JĂĽrgen T; LeBlanc, Sean J; Papadimitriou, Maria; Shahin, Rita M; Elton-Marshall, Tara E; Forchuk, Cheryl; Hopkins, Carol A; Le Foll, Bernard; Long, Dennis; Werb, Daniel M
The Goals for CRISM 2.0 are to develop and support the implementation of clinical and community-based prevention, harm reduction and treatment interventions, including guidance documents and guidelin…
The CRISM Quebec Node: building evidence for preventing, treating and reducing drug related harms
PI: Bruneau, Julie; Mary, Jean-Francois; Talbot, MĂ©lodie; Bertrand, Karine; Conrod, Patricia; Jutras-Aswad, Didier; Kaczorowski, Janusz A; Wendt, Dennis C
CRISM is a national research-practice network focused on translational and implementation research targeting substance use and related harms. CRISM consists of five regional multidisciplinary Nodes l…
PI: Wood, Evan; Tupper, Kenneth; Fairbairn, Nadia S; Johnson, Cheyenne H; Nolan, Seonaid; SocĂas, MarĂa E
Despite the enormous burden of disease attributable to harmful drug and alcohol use, major challenges remain in implementing evidence-based interventions for substance use (SU) and substance use diso…
PI: Hodgins, David C; Acoose, Sharon L; Dell, Colleen A; Hyshka, Elaine; Poulin, Ginette; Wild, Cameron T
Despite the enormous burden of disease attributable to harmful drug and alcohol use, major challenges remain in implementing evidence-based interventions for substance use (SU) and substance use diso…
With seniors being the fastest-growing age group in Canada, the need to promote healthy aging and address causes, prevention and screening for a wide range of conditions associated with aging has nev…
PI: Moll, Sandra
The purpose of this project is to build the infrastructure to support foundational and ongoing research on a new m-health platform designed to promote peer support and reduce post-traumatic stress in…
Mental health challenges affect all Canadians. Yet many Canadians lack access to mental health care services, with equity in access a key concern for specific groups due to gender, ethnicity, socio-e…
PI: Korczak, Daphne
The overall aim of this project is to understand the real-time impact of the COVID-19 public health emergency measures on children's mental health (MH) as our society re-opens, and possibly closes ag…
Understanding attitudes and beliefs toward the COVID-19 vaccines among youth with mental illness
PI: Buchman, Daniel; Henderson, Joanna L; Sockalingam, Sanjeev
Background: People with mental illness (MI) have increased risk of contracting, and dying from, COVID-19 compared to the general population. Possible explanations include behavioural and structural f…
PI: Charlebois-Plante, Camille
Estimée à plus de 42 millions de cas, l'incidence annuelle des commotions cérébrales (CC) atteint des proportions épidémiques. Une CC est un traumatisme crânien subi dans le sport qui entraîne l'appa…
Cognitive problems and sleep complaints are among the most prevalent and chronic consequences of moderate to severe traumatic brain injury (TBI). Because bad sleep may worsen cognitive consequences o…
La coercition réfère à l'utilisation de la force pour persuader quelqu'un à faire quelque chose qu'il ne veut pas. Dans le domaine de la santé mentale, le phénomène de la coercition perçue, soit l'im…
Facial Affective Memory as a Predictor of Social Function in Schizophrenia Spectrum Disorders
PI: Courtenay, Kesia
Individuals with schizophrenia have difficulty with social functioning, including core aspects of daily life like effective communication, maintaining relationships, and social roles (e.g., at work).…
PI: Fossey, Mary P
The spinal cord transmits signals from the brain to the rest of the body to perform important bodily functions. When the spinal cord is injured, brain signals might not reach below the level of injur…
PI: Cho, Lianne L
Depression is a major contributor to disability among people experiencing homelessness or living in precarious housing (i.e. housing that lacks security or stability). Although limited, past research…
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting tens of millions of people worldwide and characterized by a gradual loss of memory and other cognitive functions. Two mis…
Childhood stroke is an uncommon yet significant cause of long-term disability in children. An ischemic stroke occurs when there is a blockage of blood to a given area of the brain, resulting in brain…
Epilepsy is the most common serious neurological disorder of childhood, characterized by a propensity for recurrent seizures. Children with epilepsy have higher mortality than the general population,…
PI: Medlock, Laura M
Millions of Canadians suffer from chronic pain and its devastating effect on quality of life. Neuropathic pain, which is chronic pain caused by damage to the nervous system, is highly resistant to ex…
PI: He, Alina T
Learning and memory are mediated by long-term changes in the strength of connections between neurons, known as synapses. This neuroplasticity occurs in the hippocampal brain region and critically dep…
PI: Kao, Jennifer
Alzheimer's disease (AD) is an incurable neurodegenerative disease that is projected to affect 150 million people by 2050. Researchers believe that the memory loss observed in AD is due to a patholog…
PI: Geertsma, Haley
The molecular mechanisms underlying the pathogenesis of Parkinson's disease (PD) have been difficult to establish. However, studying alpha-synuclein (aSyn) - a known protein involved in PD pathology …
Major depressive disorder (MDD) is the second leading cause of disability worldwide. Although there are effective treatments for depression, many patients do not achieve remission, and any significan…
PI: Lee, Jiwon
Antipsychotic medications are known to put people at risk for weight gain, but these medications have not been well studied in young adults who are starting medication for the first time. As well, ev…
PI: Braga, Joeffre N
Inflammation is the body's natural response to infection or injury, like the redness that happens around a scrape on the skin. In conditions where inflammation is very active, it is possible for the …
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Current clinical care relies on managing symptoms with medication, such as a drug called levodopa. Despite taki…