CIHR Projects
Browse 44179 CIHR-funded research projects
Search & Filter Projects
Showing 101-150 of 44179 projects
PI: Ribeiro, Tiago
Cancer is the leading cause of death in Canada. According to the Canadian Cancer Statistics 2021 report 43% of Canadians will be diagnosed with cancer in their lifetime, one-quarter of which will die…
PI: Sharif, Ayni
Stroke is the second leading cause of death worldwide and the third-leading cause of death and disability combined, with more than six and a half million deaths and 143 million experiencing new perma…
PI: Desrochers, Anne
La malnutrition est fréquente dans les milieux d’hébergement tels que les CHSLD. La perte de poids et la malnutrition ont des conséquences importantes et peuvent mener au développement de plaies de p…
Human eye movements as a window into decision-making and impulsivity in Parkinson’s Disease
PI: Kuzmuk, Leah E
Parkinsons Disease (PD) is the second most common neurodegenerative disorder and affects approximately 100,000 Canadians and 5 million adults worldwide. Hallmark motor deficits including resting trem…
PI: Seo, Christina
Atrial fibrillation (AF) is a common cardiac arrhythmia which affects approximately 200,000 Canadians. Optimal long-term management of AF requires consistent follow-up with medical professionals to a…
PI: McKenna, Julia
When thinking about favourite childhood play experiences, many individuals think of activities done outdoors; this might involve climbing trees, playground games, or biking around the neighbourhood u…
PI: Pei, Julia
University students experience high rates of mental health and substance use disorders, yet they tend to have low treatment rates. Social identities (e.g., gender, sexual orientation, ethnicity) and …
PI: Lam, David D
The prevalence of social isolation stress (SIS) has been recognized within the context of the COVID-19 pandemic, correctional institutions, and declining in-person socializations. SIS is known to ind…
PI: Wang, Edward
Recent data suggests that stereotactic body radiation therapy (SBRT) may extend progression-free (PFS) and overall survival (OS) of patients with oligometastatic disease (OMD). However, SBRT is not e…
Inflammatory bowel disease (IBD) is a debilitating chronic disorder that targets the gastrointestinal (GI) tract. Although the cause remains unknown, recent studies have identified the association be…
PI: Asbury, Rachel E
Infections by pathogenic bacteria present a health challenge to humans and animals, and with the increasing problem of antibiotic resistance, alternative treatments to antibiotics are needed. Enginee…
PI: Georges, Gabriel
L’insuffisance cardiaque (IC) est une maladie chronique incurable qui affecte plus de 600,000 Canadiens. Les patients avec IC réfractaire à la médication sont sans issue ; il s’agit de patients fragi…
PI: Mokhtari, Masoud
Ejection Fraction (EF) is a cardiovascular measurement indicating the amount of blood pumped by the heart. A low EF value can be an indicator of imminent heart failure, and therefore, monitoring chan…
Background: Bone is a dynamic, living tissue that undergoes continuous change throughout life. Current literature suggests that opioid use alters the way bone cells heal and maintain bone tissue. Opi…
Endometriosis, Infertility, and Assisted Reproductive Technologies: Associations and Experiences
PI: Karim, Jalisa L
Endometriosis is a chronic condition that affects approximately 1 million people across Canada. It occurs when tissue similar to endometrial tissue (the inner lining of the uterus) grows outside of t…
PI: Tanti, Amanda C
There are numerous advantages to a bachelors degree in nursing. Bachelor-trained nurses report increased levels of job satisfaction due to a greater sense of autonomy and more diverse career opportun…
Cardiorenal benefits of sodium-glucose cotransporter 2 inhibition in type 1 diabetes mellitus
Diabetes mellitus is one of the fastest growing public health crises worldwide and accounts for 6% of global prevalence. Chronic high blood glucose, a hallmark of diabetes, stems from impaired insuli…
PI: Pain, Rony
Myristoylation is the modification of proteins by a piece of fat named myristate. The two enzymes named NMT1 and NMT2 transfer myristate are found in healthy cells. The Berthiaume lab discovered a pi…
PI: Houston, Annecy
Hypermobile Ehlers-Danlos Syndrome (hEDS) and Generalized Hypermobility Spectrum Disorder (G-HSD) are heritable connective tissue disorders with multisystemic repercussions. Common symptoms include w…
PI: Momen, Rozhan
Background:Patients with pulmonary arterial hypertension (PAH) have high pressure in the blood vessels that carry blood through the lungs to the heart. Recent PAH studies have shown a high percentage…
Depuis plusieurs années, les pays membres de l’OCDE (Organisation de Coopération et Développement Économiques) ont connu une forte croissance de flux migratoires. D’après Abel (2016), le nombre d'ent…
PI: Leda, Mariela
Epilepsy is a common neurologic condition defined by spontaneous, recurrent seizures. The literature shows that children with epilepsy (CWE) are at risk for psychological disorders, including depress…
Breast cancer is the most frequently diagnosed cancer in women, and although the 5-year overall survival rate is over 85%, the development of therapy resistance and progression into a metastatic dise…
PI: Thomas, Anjali L
Inflammatory bowel disease (IBD) is a chronic, debilitating condition which affects thousands of Canadians yearly and for which there are few long-termed therapies. This holds especially true for pat…
La tétralogie de Fallot est la malformation cardiaque cyanogène la plus commune en touchant 0,2 à 0,5 des nouveau-nés par 1000 naissances. Elle se caractérise par une communication entre les deux ven…
Cardiovascular (CV) disease is the leading cause of death in women globally, highlighting the importance of studying sex-specific cardiovascular risk factors, such as exposure to estrogens. Globally …
PI: Huang, Yijia
Duchenne Muscular Dystrophy (DMD) is a muscle disease without current cure that results from a defect in the muscle protein dystrophin. Lack of dystrophin makes the muscle fragile and susceptible to …
PI: Hernandez, Laura
Numerous short- and long-term implications have been reported in survivors of Coronavirus 2019 Disease (COVID-19). Many patients with COVID-19 may have had heart disease related conditions or may hav…
Choisir d’être stressé(e): Impact sur la réactivité cortisolaire chez les jeunes adultes
PI: Beaumont, Emy
Nous vivons tous du stress au quotidien. Chaque fois que nous faisons face à une menace (stresseur), une réponse physiologique de stress est générée afin de nous aider à y faire face. Elle mène entre…
PI: Uehara, Maria A
The number of people who are living with dementia, which can be characterized by the impairment of their cognition, is increasing with time. Through the activation of the brain using the transcranial…
PI: Kullman, Sasha M
Cardiovascular disease (CVD) is a leading cause of death for Canadian women. Physical activity helps to prevent CVD, but 85% of Canadians are inactive. Difficult emotions about CVD risk may hinder at…
Anxiety disorders are a common mental health issue for many individuals. When someone has generalized anxiety disorder (GAD) they experience chronic and uncontrollable worry accompanied by various ph…
More children die when they are newborns than in any other period of childhood. Many of these infants die in the neonatal intensive care unit (NICU). These units commonly provide palliative care. Pal…
PI: Gao, Zihan
Chronic post-surgical pain (CPSP), which is pain that persists two months after surgery without a known cause, is a reality for up to 50% of patients who undergo cardiothoracic surgery. For patients …
Each cell in our body contains tens of thousands of genes, which are coded in DNA. In order for a cell to use these genes, it needs to create a temporary disposable copy. This copy is called messenge…
PI: Lee, Kiera J
Synovial sarcoma is a soft-tissue malignancythat mainly affects adolescents and young adults. Unfortunately, standard chemotherapeutics do not increase survival, creating a need for targeted therapie…
PI: Cuda, Natalie M
Background: Breast cancer survivors (BCS) may experience poor mental health following chemotherapy treatment. The COVID-19 pandemic has exacerbated these symptoms leading to increased levels of anxie…
PI: Nikolsky, Anita
The immune response to infectious molecules is highly dependent on the evolution of key immune cells. For instance, binding of a pathogenic molecule to a B cell elicits a cellular response to produce…
PI: Braddon, Kate E
The ways in which childhood obesity and nutritional behaviours develop is a complex area to investigate as it involves many different factors. The health of the mother in the preconception period has…
Hemifacial Microsomia (HFM) is one of the most common congenital craniofacial disorders. Among many other features, microtia is present in the large majority of these patients. However, mainly due to…
PI: Chopra, Sameeksha (Maggie)
Allergic diseases such as food allergies and asthma are increasing worldwide, with approximately 30% of the global population currently affected. Increasing evidence suggests that early-life environm…
Given Nova Scotia's ageing demographic and impact on patients, their communities, and the healthcare professionals who work with them, it is critical to understand how and in what ways design and des…
PI: Tieu, Thuan Minh
Acute lymphoblastic leukemia (ALL) is a serious public health problem in the pediatric population affecting 1 in 1,500 children worldwide, and contributes to 85% of deaths from childhood cancer. It i…
PI: Kennedy, Molly
Declarative memory (DM) is a multidimensional cognitive process involving our ability to encode, store, and retrieve both personal information (i.e., I visited New York last year) and general knowled…
PI: Taal, Dirk B
Oncolytic viruses can be used to target and destroy cancer without harming healthy cells. Clinical trials using an oncolytic reovirus have shown positive results, though the optimization of treatment…
PI: Musani, Iman
Mental health-related harms and suicide are significant public health crises among Indigenous populations in Canada. Poor mental health outcomes have been attributed to lasting impacts of colonizatio…
PI: Buron, Laurianne
Pediatric brain tumor survivors often have social competence difficulties. For example, they are more likely to have no friends compared to other children. Their social difficulties also continue int…
PI: Simard, Cléa
Avec la récente légalisation du cannabis au Québec, les répercussions de la consommation de cette substance sur le cerveau des adolescents sont d’une préoccupation grandissante. Le cannabis est large…
The threat of antimicrobial resistance is exemplified by the multidrug-resistant (MDR) ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, P…
Identification and Structure Determination of a Potentially Novel Anti-Staphylococcal Antibiotic
PI: Kirk, Ashlyn M
The antimicrobial resistance crisis caused by the evolution of multi-drug resistant human pathogens is a prominent issue in healthcare. Staphylococcus aureus is a problematic bacterium in this area, …