CIHR Projects
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Showing 101-150 of 7698 projects for "cancer"
PI: Zhang, Yi Yun
Cancer has permeated through our population and touched Canadians in all walks of life. Nearly 1 in 2 Canadians are expected to be diagnosed with cancer in their lifetime and cancer is the leading ca…
Autophagy is a conserved cellular degradation pathway that regulates cell survival and invasion. There is a dual role of autophagy in tumour suppression and progression depending on the cancer. This …
PI: Rana, Benny
Exercise plays a supportive role across the cancer care continuum, addressing symptom and treatment-related negative impacts. While the burden of such impacts may be substantial for all individuals l…
PI: Xu, Lingtong
Neoadjuvant therapy (NAT) is a key stage in the treatment of early breast cancer. Being able to properly assess a patient's response to NAT provides important information on their survival and cancer…
PI: Yang, Kevin
Cancer is driven by mutations that follow an evolutionary process, producing genetically distinct populations of cells known as clones. As a result, these clonal populations have varied responses to …
Étude des mécanismes d’adaptation gastrique et d’acclimatation acide chez Helicobacter pylori
PI: Beniani, Meriem
Our model is the absorption system of nickel ions in Helicobacter pylori,one of the most performant human pathogenic agents causing light to severe gastric pathologies. These bacteria are considered …
Le cancer est la famille de maladies qui causent le plus de décès au monde. Un des mécanismes importants dans la progression du cancer est le partage de cargo et la communication intercellulaire par …
PI: Nault, Braydon
Breast cancer has a very high survival rate when the disease is detected in an early stage. However only about 64% of all cases are found this early. An improved method of screening is needed in orde…
PI: Johnston, Liam
When Transplant Therapy Goes Awry: Investigating the Molecular Changes in Graft Versus Host DiseaseStem cell transplantation is a lifesaving treatment for people with advanced blood cancers. However,…
PI: Haque, Bushra
Reading entire DNA sequences of individuals provides a comprehensive view of the unique genetic variation that contributes to a breath of diseases, from rare genetic disorders to common cancers. A co…
PI: Gill, Paramjot K
The Canadian Partnership for Cancer (CPAC) reports that approximately 7,600 adolescents and young adult (AYA) Canadians aged 15 to 39 years are diagnosed with cancer every year. Currently, there is l…
PI: Wei, Xinyu
T cell receptor (TCR) gene therapy involves the adoptive transfer of T cells engineered with high-affinity TCRs to induce a clinically effective anti-tumor response. Results of recent clinical trials…
PI: Goodwin, Emma
Endometriosis affects roughly 1 million women in Canada, is a main cause of pelvic pain and infertility, and is associated with ovarian cancer development. It is a chronic, estrogen-dependent, inflam…
PI: Lu, Ingrid J
Cervical cancer (CC) is a major cause of mortality in women globally. CC disproportionately affects women in lower-income countries due to gender inequality, lack of access to effective and efficient…
Développement de trois mesures de la peur de la récidive clinique chez les survivants du cancer
La peur de la récidive est définie comme étant la peur ou la préoccupation de la personne que le cancer revienne dans la même ou une différente partie du corps. Les conséquences de la PRC selon sa sé…
PI: Frame, Gavin C
Prostate cancer (PCa) is the most commonly diagnosed cancer in male Canadians, yet resistance to radiation treatment leading to metastatic progression is still a cause of significant morbidity and mo…
Breast cancer is the most common form of cancer among women and although treatment for breast cancer have progressed in recent years, many eventually become resistant to initial treatment. Therefore,…
Investigating functions of the Epstein-Barr virus protein BRRF1 in host and viral gene regulation
PI: Ho, Talia M
The Epstein-Barr virus (EBV) is a widespread virus that infects nearly all adults worldwide. Infection is life-long, as the virus hides within the bodys immune cells and is skilful at escaping detect…
Breast cancer is a major public health concern in Canada. Although the current combination of surgery, radiation, and chemotherapy may lead to a cure in the breast cancer setting, the administration …
PI: Poulton, Emily
Pancreatic cancer (PC) is an extremely aggressive disease that requires a better understanding to improve treatment options. The 4 Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) are key playe…
PI: Nkankeu Gnekouang, Sylvain V
Messenger RNA (mRNA) is a molecule that carries DNA-encoded information outside of the nucleus to be translated into proteins. Polyadenylation is an mRNA maturation process that involves the addition…
The proposed project centres around a group of immune cells called Mucosal-associated invariant T (MAIT) cells. Even though these cells make up a sizeable portion of all T cells in the human immune s…
PI: Lau, Asa
Lung cancer is the leading cause of cancer death in Canada. While there have been advances in therapies to treat lung cancer, high rates of drug resistance and tumour recurrence emphasize the need fo…
PI: Moore, Alissa
Research indicates that firefighters are at greater risk of developing and dying of cancer than the general population. In Canada, many cancers are designated presumptive illnesses for firefighters, …
PI: Wu, Angela
Fluoropyrimidines are commonly prescribed anti-cancer drugs but they cause severe adverse drug reactions in up to a third of patients. The same dose of one drug may be efficacious and safe in one per…
PI: Winn, Allison K
Pancreatic cancer is one of the deadliest human cancers, with a 5-year survival rate of only 8%. Pancreatic tumours tend to go undiagnosed until they are quite advanced, at which point they are unres…
Monoclonal antibodies (mAbs) have revolutionized cancer therapy, and trastuzumab has revolutionized HER2+ breast cancer. Increasingly, antibody drug conjugates such as trastuzumab emtansine play an i…
PI: Arreza, Leanne
A network of different cell types within a tumor, such as cancer stem cells and immune cells, regulates tumor growth and survival. Current drugs are ineffective in the targeted disruption of cancer s…
In 2018, Head and Neck Squamous Cell Carcinoma (HNSCC) was the 6th most common cancer worldwide with approximately 890 000 new cases and 450 000 deaths. The burden of HNSCC is expected to rise by 30%…
PI: Kwong, Jethro C
Bladder cancer is the 5th most common cancer in Canada with about 75% of these patients being diagnosed with non-muscle invasive bladder cancer (NMIBC), in which the tumour does not infiltrate the mu…
Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the deadliest and most prevalent cancers with rising incidence. The treatment options are non-selective and associated with toxicities and othe…
PI: Montpetit, Jade
La thérapie contre le cancer peut rendre nos cellules sénescentes, un état qui signifie l’arrêt de leur multiplication. En cancer, les cellules se divisent de façon incontrôlée : la sénescence peut ê…
The proposed research project focuses on validating an epidemiological risk model to improve targeted prevention strategies for endometrial cancer (EC), or cancer of the uterus. This gynaecological c…
PI: Young, Karen
We were always here - adapting virtual care for Chinese Canadian prostate cancer survivorsProstate cancer (PCa) is the most commonly diagnosed cancer in Canadian men. 1 in 8 men in Canada will be dia…
Ovarian cancer is the most lethal gynecological cancer and has a 5-year survival rate of less than 45%. About 20% of patients with high-grade serous ovarian cancer have mutations in the genes. These …
In Canada, breast cancer is the most common form of cancer. Thankfully, with evolving diagnostic technologies over the past century, the survival rate for breast cancer is 89%. Unfortunately, this in…
PI: Principe, Miguel Alfonso V
Soft tissue sarcomas (STS) are rare cancers that come from muscles, fat, and cartilage. Half of all patients have metastases, which are tumours that grow in another part of the body. In STS, metastas…
PI: Ibrahim, Dalia K
Ovarian cancer is the most lethal gynecological cancer worldwide and has a 5-year survival rate of less than 40%. Women are usually diagnosed after their cancer has grown large and/or spread througho…
Context: In recent years, an improved understanding of the biology of cancer paired with the development of therapies targeting known cellular culprits of cancer have revolutionized the treatment of …
PI: Chu, Ryan
Background: Lung cancer is the most commonly diagnosed and leading cause of cancer death in Canada. Novel treatments like pembrolizumab (PEM) fall under a novel treatment class called immunotherapy. …
PI: Shi, Xin Ping
Ovarian cancer ranks fifth in cancer deaths among women (~1,800 and ~14,000deaths/year in Canada and U.S., respectively), accounting for more deaths than any other cancer of the female reproductive s…
Defining clinically important bleeding outcomes for clinical trials in hematological malignancies
PI: Taneja, Shipra
Approximately 6,900 Canadians are diagnosed with acute leukaemia (AL) each year. AL and its treatments cause patients to bleed more easily. In clinical trials, researchers use bleeding as an outcome …
PI: Longakit, Anne Nathalie Ruth M
Uveal melanoma is the most common cancer of the eye. Every year, approximately 130 Canadians are diagnosed with uveal melanoma, which kills approximately half of patients within 1 year due to uncontr…
PI: Niu, Emily
Lung cancer is the most common cancer in the world and the leading cause of death worldwide. Most lung cancers are non-small cell lung cancers (NSCLCs) and brain metastasis in NSCLC patients is highl…
Chimeric antigen receptor (CAR)-T cell therapy has led to improved survival for some patients with relapsed/refractory acute lymphoblastic leukemia (ALL). This therapy involves engineering T cells, a…
PI: Forgie, Benjamin
Ovarian cancer is a deadly disease with limited options for treatment. Typical treatment for ovarian cancer consists of a combination of surgery and chemotherapy with cisplatin (CDDP). While this ini…
PI: Patel, Ujas A
Small-cell lung cancer (SCLC) is a highly aggressive and lethal type of lung cancer. Patients diagnosed with extensive-stage (ES), in which the cancer has spread to other parts of the body, are treat…
PI: Jogiat, Uzair M
Background: Sarcopenia is defined as the chronic decrease in muscle mass and function. It is part of the aging process, and can be accelerated by disease and malnutrition. In esophageal cancer, sarco…
Our natural defence against disease-causing germs is known as the immune system. The immune system is constantly protecting our bodies from disease-causing agents such as bacteria and viruses. To fig…
The field of molecular genetics is budding, and advances in recent years have enabled the investigation of health at a genetic level. However, there is a large gap in the knowledge regarding the effe…