CIHR Projects
Browse 2832 CIHR-funded research projects
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Showing 101-150 of 2832 projects for "diabetes"
PI: Jung, Mary E; Alexander, Amanda; Allen, David P; Casmey, Samantha; Compton, Steve; Cullen, Lon; Hartley-Folz, Samantha; Hughes, Crystal L; Paterson, Kent; Squires, Sherry; Bean, Corliss; Li, Linda C; Mckay, Heather A; Witteman, Holly M
More than 6 million Canadians are at risk for developing type 2 diabetes (T2D). Laboratory-based diabetes prevention programs have not been effective when translated into community settings, mainly d…
PI: Booth, Gillian L; Gebremikael, Liben M; Bacon, Simon L; Ke, Calvin; Lofters, Aisha K; Rainham, Daniel Gareth C
Lifestyle interventions consisting of physical activity and weight loss can prevent or delay the onset of diabetes in people who have earlier stages of disease (known as prediabetes). While these int…
PI: Klein, Doug; Lessard, Sean M; Boushel, Robert C; Svrcek, Clark; Wicklum, Sonja C
The CHANGE Health Community Program is a program to help families "re-learn" healthy living by providing lifestyle intervention programming in four main areas (physical activity, nutrition, mental he…
PI: Matthews, Stephen G; Sellen, Daniel W; CHANDAK, GIRIRAJ R; Comelli, Elena M; Krishnaveni, Ghattu V; Kumaran, Kalyanaraman; Shah, Prakeshkumar; Suryanarayana, Kumar G; Wade, Mark
The health and economic burden of non-communicable diseases (NCDs) is increasing rapidly worldwide particularly in low- and middle-income countries (LMICs), where ~75% of global deaths from NCDs occu…
PI: Lye, Stephen J; Clinton, Jean M; Lule, Elizabeth L; Connor, Kristin L; Draper, Catherine E; Hung, Rayjean; Norris, Shane A
The burden of non-communicable diseases in low- and middle- income countries is significant and increasing due to several risk factors including undernutrition at early age, sedentary behaviour, poor…
Mental Wellness & Resilience: Co-creating a Collective Vision with Urban Indigenous Communities
This research will work with five Friendship/Métis Centres (FC/MCs) in British Columbia to develop a vision for community mental wellness grounded in people's experiences of living with diabetes. Ind…
Bitter-sweet role of glucose: Uncovering the dynamic of transient hyperglycemia-mediated longevity.
Hyperglycemia (high glucose concentration) is associated with metabolic and age-related disorders. Chronic hyperglycemia is responsible for insulin resistance, obesity, hypertension, and neuropathies…
PI: Levin, Adeera; Beaucage, Mary B; Desjarlais, Arlene D; Hillier, David R; McCormick, Michael; Morrin, Louise; Stalker, Leanne; Verdin, Nancy E; Voyageur, Evelyn; Wilson, Mary; Woods, Cathy; Ahmed, Sofia B; Barrett, Brendan J; Battistella, Marisa; Bello, Aminu; Bohm, Clara; Collister, David; Dart, Allison B; Donald, Maoliosa (Mo); Elliott, Meghan; Garg, Amit; Hartwig, Sunny; James, Matthew T; King, Malcolm; Louie, Kelsey; Manns, Braden J; Matsuda-Abedini, Mina; McIntyre, Christopher W; Reich, Heather; Rigatto, Claudio; Sapir-Pichhadze, Ruth; Schick-Makaroff, Kara L; Scholey, James W; Silver, Samuel; Tangri, Navdeep; Tennankore, Karthik K; Thompson, Stephanie; Wicklow, Brandy A; Zappitelli, Michael
Chronic kidney disease (CKD) is a complex condition that affects 1 in 10 Canadians and is estimated to cost Canadian healthcare more than $50 billion each year. Patients with CKD have often been excl…
PI: Wei, Xiaolin; Khan, Haroon J; Khan, Muhammad Amir
As the world struggles to contain the Covid-19 pandemic, the crisis has revealed a great deal about the gaps in global health systems, especially in the low- and middle-income countries (LMICs). Evid…
PI: Haas, Kurt
The COVID-19 pandemic has had greatest impact on marginalized populations including Indigenous, Black and Latino communities. A leading question of the COVID-19 pandemic is why distinct ethnic or reg…
PI: Walmsley, Sharon L; Gingras, Anne-Claude; Rochon, Paula A
There has been rapid approval of the COVID-19 vaccines. The participants in the initial research were mostly Caucasian with an average age of 50 years and with little underlying illness. More informa…
Metformin administration restores depleted NAD levels to improve outcomes in elderly burn patients
PI: Barayan, Dalia
Severe burns account for an estimated 330,000 deaths per year worldwide- ranking fourth in incidence among all forms of trauma. While modern burn care has markedly improved survival for pediatric and…
PI: Budd, Matthew
Type 1 diabetes (T1D) is an incurable, life-long autoimmune disease that affects ~300,000 Canadians. In T1D, the immune system attacks and destroys beta cells in the pancreas that normally produce in…
PI: Lofft, Zoe
Folate is a critical nutrient required for development. Folic acid (FA), the synthetic form of folate, has been fortified into grain products in Canada, which has greatly reduced neural tube defects.…
Patients with Type 1 Diabetes (T1D) have immune cells that wrongfully kill clusters of cells in the pancreas called islets, which are the body's sole producers of insulin. Without insulin, the body c…
PI: Iyer, Janaki S
Sjogren's syndrome (SS) is a longstanding, progressive disease that is predominant in women and primarily involves decreased bodily fluid secretions. Lack of saliva and its associated symptoms, such …
PI: Traa, Annika
Aging is the greatest risk factor for age-related diseases such as cancer, diabetes, cardiovascular disease, and neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's disease. …
PI: Prowting, Joel L
Dairy products are important sources of vitamins, minerals, and other beneficial molecules. Human research shows that dairy products can be anti-inflammatory and improve other markers of health. Infl…
PI: Carew, Allie S
People with type 2 diabetes have a higher risk of heart disease compared to people without type 2 diabetes. However, studies of strict blood sugar control (aiming for near-normal blood sugar levels) …
The implication of human adipocyte hypertrophy in systemic lipid metabolism and insulin resistance
PI: Ye, Run Zhou
Diabetes is a chronic illness affecting more than 2 million Canadians. There are two types of diabetes: type 1 diabetes and type 2 diabetes. Almost all patients with diabetes have type 2 diabetes. Th…
PI: Marko, Daniel
Many Canadians are overweight or obese and have a higher risk of type 2 diabetes and other metabolic diseases such as fatty liver disease. Sticking to a diet to prevent or reverse obesity and metabol…
PI: Alexander, Robert T; Beaucage, Mary B; Burns, Kevin D; Farragher, Janine; Hartwig, Sunny; Ho, Julie; King, Malcolm; Konvalinka, Ana; Levin, Adeera; Madore, François; Pandeya, Sanjay; Schick-Makaroff, Kara L; Stalker, Leanne; Tennankore, Karthik K
The Kidney Research Scientist Core Education and Training (KRESCENT) Program 2.0 will expand and improve the successful original program, a unique, innovative and sustained collaboration between foun…
PI: Jones, Nicola L; Bhat, Mamatha; Hirota, Simon A; Kaplan, Gilaad G; Lee, Kate; McKay, Derek M; Otley, Anthony R; Pena-Sanchez, Juan-Nicolas; Perreault, Nathalie; Reynolds, Lisa A; Rose, Christopher; Targownik, Laura E; Vallance, Bruce A; Verdu, Elena F
A healthy gut is key to good health and wellbeing. However, changes within our bowel and the bacteria housed in our gut can lead to diseases in our intestine such as inflammatory bowel disease, or ir…
PI: Tchernof, André; Ball, Geoff D; Blondin, Denis; Brunt, Keith R; Colquhoun, Heather; Doucette, Christine A; Forhan, Mary A; McGavock, Jonathan M; Parry, Monica J; Screaton, Robert A; Sénéchal, Martin; Wei, Xiaolin; Wing, Simon S
Canada is fortunate to have many highly productive research teams, networks and institutions, tackling a range of research gaps in the prevention and treatment of diabetes, obesity and cardiometaboli…
The flu leads to about 20,000 hospitalizations and 5,000 deaths per year in Canada - and up to 100 times more globally. We underappreciate that this is mostly due to heart disease complications. Evid…
Li-Fraumeni Syndrome (LFS) is a genetic condition which drastically increases the risk of developing a spectrum of early-onset cancers. 1 in 5000 people are affected by LFS, and 80% of LFS patients a…
PI: Wu, Che-Yuan
Dementia is a major challenge for individuals, families, and the health care system. It is frustrating that effective treatment options are lacking. This necessitates the development of effective pre…
Cardiac Magnetic Resonance Guided Exploration of Heart Failure with Preserved Ejection Fraction
PI: Troy, Aaron
Heart failure is a debilitating, complex, and often terminal disease that effects over half a million Canadians. Despite decades of research, our understanding of a large category of heart failure ca…
High intake of sugar-sweetened pop has been linked with excess weight gain and an increased risk for type 2 diabetes and heart disease. Because of this, health experts have recommended that people re…
PI: Landry, Chloé
The immune system is essential to protect the body from disease-causing bacteria or viruses. One way that the immune system protects the body is by releasing "extracellular traps". These traps are ma…
Disrupted sleep is common during pregnancy and has been thought to be involved in the development of pregnancy complications. Sleep disordered breathing (SDB snoring or pauses in breathing at night) …
People who live with chronic illnesses (e.g., diabetes, arthritis, lupus) must undertake a variety of tasks to monitor and manage their health (self-management). Understandably, these extra responsib…
PI: Ghasemian Moghaddam, Mohammadamir
In the pancreas, alpha-cells release glucagon (which causes blood sugar to go up) and beta-cells release insulin (which causes blood sugar to go down); and for the control of blood sugar, secretion o…
Elucidating the relationship between molecular biomarkers of aging and metabolic multimorbidity
PI: Wu, Jianhan
Our healthcare system is overburdened by the increasing prevalence of metabolic multimorbidity, a condition characterized by the co-occurrence of different, yet related, metabolic diseases. Approxima…
PI: Yu, Amy Ying Xin; Sharp, Shelley
Every 9 minutes, someone in Canada experiences a stroke. Stroke is the third most common cause of death among Canadians. Risk factors for stroke include high blood pressure (hypertension), sugar (dia…
PI: Gibb, James K
About one million people in Canada identify as a member of the Lesbian, Gay, Bisexual, Transgender, Queer (LGBTQ+) community, however, recent data from Statistics Canada indicates that discrimination…
PI: Soussi, Sabri M
In Canada, sepsis strikes young and old alike with an incidence of ~100 000 cases per year. Mortality remains between 20 and 40%, and the incidence is rising (8.7%/year). Survivors have long term mor…
Background: Type 2 Diabetes (T2D) is among the fastest growing illnesses worldwide and its prevalence is rapidly increasing. While awareness is mounting of T2D-related biological complications, there…
PI: Shakiba, Nika
Type 1 diabetes (T1D) is a debilitating disorder affecting millions of Canadians, generally from childhood. Patients with T1D lack functional beta cells that release insulin, making cell replacement …
PI: Booth, Gillian L
The pandemic has placed an unprecedented strain on our society. While public health measures have been effective in flattening the curve to reduce COVID-19 infections, they have led to widespread red…
Gestational diabetes mellitus (GDM), defined as high blood sugar that is first recognized during pregnancy, affects up to 1 in 6 pregnant women worldwide and carries risks for both mother and child. …
PI: Samaan, M. Constantine; Thabane, Lehana
Around 5400 children in North America are diagnosed with brain tumors every year, making them the most common solid tumors in children. The good news is that advances in cancer care have dramatically…
Our vision is to establish a complete understanding of the biology of human beta cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabet…
PI: Advani, Andrew
Kidney disease is one of the most devastating complications of diabetes. We urgently need new treatments. Sometimes kidney disease in diabetes develops gradually over years. This is called chronic ki…
Healthy eating during pregnancy has favorable effects on markers related to diabetes (glucose tolerance) and is associated with lower gestational diabetes mellitus (GDM) risk. The cornerstone of GDM …
PI: Chan, John S
Diabetes and high blood pressure are major risk factors in the development of heart disease, including stroke, heart attacks and kidney failure. Keeping blood sugar at normal levels with insulin and …
PI: Marette, André
Obesity and type 2 diabetes (T2D) are chronic diseases that affect millions of people worldwide. A variety of diets have been proposed to offset obesity and T2D but the focus has been mainly to reduc…
We live in a 24-hour world where our daily activities are organized around the day-night cycle. Many of us wake up, eat our meals, go to work, and sleep at approximately the same time every day. Our …
A large percentage of the general population is affected by periodontal diseases. Associated with this inflammation is loss of tooth-supporting bone and, if severe, loss of teeth and ultimately funct…