CIHR Projects
Browse 1992 CIHR-funded research projects
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Showing 1951-1992 of 1992 projects
PI: Lund, James P; Kolta, Arlette
Chronic muscle pain conditions are very prevalent in the Canadian population, particularly in women of child-bearing age. We are studying the aetiology and possible treatments for these conditions, u…
PI: Roy, Stéphane M
Regenerative medicine is the new frontier of biomedical sciences that promises to unlock the secrets of how the body generates and repair itself. The ability to regenerate lost of damaged tissues wou…
Bone fracture disrupts the circulation around a fracture and leads to acute necrosis and hypoxia of adjacent bone and marrow. Severe fracture may lead to delays in bone healing or nonunion. There are…
PI: Murshed, Monzur
Lay Abstract: Bones and teeth are hard tissues, the usual sites for physiologic mineral accumulation. These mineralized tissues protect the internal soft organs, help in locomotion, facilitate food p…
Osteoarthritis (OA) is characterised by progressive joint destruction, inflammation and pain. There are no specific ways to stop OA and, because of its nature, only treatments begun during the early …
PI: Mitchell, Jane A
Glucocorticoids are a group of steroid drugs that are used to treat inflammatory conditions such as asthma, arthritis and inflammatory bowel disease. One of the major side-effects of these drugs is o…
PI: Luo, Hongyu
TL1A is a molecule that can stimulate T lymphocytes. In our pilot study, we showed that mice injected with this molecule had severer rheumatoid arthritis (RA). This molecule could increase antibody p…
Proton pump inhibitors (PPIs) are among the most commonly prescribed medications in clinical practice. PPIs are the most effective medications for reducing the production of stomach acid, and as a re…
During healing of skin, cells form a scaffold within the wound known as the provisional matrix. The matrix allows cells to move into the wound and repair the damaged tissue. The matrix is composed of…
PI: Cheung, Angela M
Clinical trials have shown that teriparatide, a bone formation drug, increases bone mineral density (BMD) at the lumbar spine and total hip, but decreases BMD at the forearm after 20 months of therap…
Arthritogenicity of the immune response to citrulline in mice and in human Rheumatoid Arthritis.
PI: Cairns, Ewa
Rheumatoid Arthritis (RA) is a common, chronic and crippling disease that destroys cartilage and bone in the joints. The cause of RA is not known but it has been shown that a molecule called the shar…
PI: Bray, Robert C
Injury to the anterior cruciate ligament (ACL) causes instability of the knee, resulting in other knee structures being subjected to abnormal forces. These supporting joint connective tissues such as…
PI: Thornton, Gail M
Damaging loads injure ligaments and tendons differently based on differences in how their structures are assembled. The assembly of these structures during maturation may be affected by the absence o…
PI: Aiken, Alice B; Brouwer, Brenda J
The main goal of the proposed study is to determine the nature and extent of physical, psychological, and radiographic changes in patients awaiting hip and knee replacement surgery. We propose that k…
PI: Yeung, Rae S
The overall objective of our team is to understand why the body damages the blood vessels in Kawasaki disease (KD) and to identify new biologic markers that will aid in identification of children at …
The experience of illness is individual, and depends in part on contextual factors such as financial circumstances and a supportive work environment. Researchers do not yet fully understand how these…
PI: Li, Linda C; Adam, Paul
For people with rheumatoid arthritis (RA), the period shortly after the diagnosis is often filled with uncertainties and anxiety as they are searching for information to make treatment decisions. The…
PI: Johnson, James A
Replacement of the fractured or diseased elbow with implants is becoming an increasingly popular treatment, with the intent to restore function and reduce disability and pain. However, failure to cor…
PI: Yeung, Rae S
The overall objective of our project is to understand why the body damages the blood vessels in Kawasaki disease (KD), the leading cause of acquired heart disease in Canadian children. An infection s…
PI: McElwee, Kevin J
A form of skin cancer called basal cell carcinoma (BCC) develops due to sun light induced gene mutations in skin and hair follicle cells. Over 70,000 cases of BCC occur in Canada each year which are …
PI: Laird, Dale W; Bai, Donglin; Kidder, Gerald M
In normal human physiology, most cells directly talk to each other through specialized conduits or channels that are built between contacting cells within tissues and organs. The protein molecules us…
PI: Feldman, Brian M
Scleroderma (SSc) is a disease that can affect the skin, joints and internal organs (heart, lungs, kidneys). There is no cure. The leading cause of death for Canadians with SSc is high pressure in th…
Premature heart disease is a significant problem in patients with lupus. We have found that a pre-diabetic state (the metabolic syndrome) is more common in SLE but the causes are unclear. This pre-di…
The fundamental action of vitamin D in the treatment and prevention of rickets was discovered over 60 years ago, but it is only recently that this compound was shown to have unique properties for tre…
PI: Richards, Brent
Osteoporotic fractures are a common and debilitating problem, which are strongly influenced by our genes. Although many environmentally determined risk factors for osteoporotic fractures have been id…
PI: Sevigny, Jean
Leukocytes and endothelial cells play key roles in inflammation and arthritis by releasing chemokines such as IL-8. IL-8 promotes the migration of neutrophils that rapidly accumulate in the inflamed …
La vessie est un réservoir élastique responsable de l'emmagasinage de l'urine à basses pressions. Dans certaines conditions pathologiques, la fonction du muscle vésical est altérée et mène à des pres…
PI: Cobb, John A
Transcription factor proteins introduce pattern into the embryo by controlling gene expression. One such patterning process is the formation of the limbs (arms and legs). Different transcription fact…
This proposal is aimed at identification of the genes/proteins which confer susceptibility to rheumatoid arthritis (RA). RA is a chronic inflammatory disease in which the tissues lining the joints be…
Microbiologists have traditionally focused on free-floating bacteria growing in laboratory cultures; yet they have recently come to realize that in the natural world more than 99% of all bacteria liv…
Total joint replacement of the hip and knee, TJR, is effective in reducing pain and improving mobility in Canadians with hip/knee arthritis when medical treatment fails. However, studies show that ma…
PI: Vacher, Jean
The overall objective of our laboratory is to understand the molecular and cellular mechanisms that regulate bone homeostasis. Bone homeostasis requires equilibrium between bone formation and bone re…
PI: Bobyn, John D; Tanzer, Michael
Many joint replacement devices are attached directly to bone by encouraging bone formation in and around the implant surface. The use of drugs such as bisphosphponates that enhance local bone formati…
PI: Sessle, Barry J
Our studies will help clarify the role of the cerebral cortex in adaptive mechanisms associated with an altered oral environment and the learning of new motor skills, and thus provide new insights in…
PI: Hussain, Sabah N
Patients with Duchenne Muscular Dystrophy (DMD) suffers from severe muscle weakness and injury and die of respiratory failure because of inability of the respiratory muscles to ventilate the lungs. T…
PI: Kowal, John
Chronic pain is a complex, prevalent, and costly health condition. Between 9 and 29 percent of Canadian adults live with chronic pain. Attachment Theory is a developmental, interpersonal framework th…
PI: Goldberg, Harvey A; Hunter, Graeme K
The organic matrices of mineralized tissues consist principally of type I collagen and a variety of non-collagenous proteins. These proteins are postulated to have critical roles in tissue developmen…
PI: Jamal, Abida Sophina; Lok, Charmaine E
Broken bones (fractures) due to osteoporosis "or thinning of the bones" are common in men and women with kidney disease. For example, just over half of men and women with kidney failure needing dialy…
Muscle wasting is a significant problem in chronic obstructive pulmonary disease (COPD) which is associated with important clinical issues such as decreased functional status, reduced quality of life…
PI: Brison, Robert J; Brouwer, Brenda J
Soft tissue injuries to the ankle (ankle sprains) are common injuries treated in Canadian emergency departments. An important proportion (up to 40%) of these injuries result in chronic functional lim…
PI: Jomha, Nadr M
Injuries to and diseases of joint cartilage can lead to osteoarthritis (0A) affecting 4 million Canadians with 60% younger than 65 years of age. OA is the second leading cause of work disability in N…
The skeleton is very important for daily activities such as walking and posture. It is hence important for quality of life for an individual. Cancers that primarily arise within the bone or that have…