CIHR Projects
Browse 2220 CIHR-funded research projects
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Showing 2201-2220 of 2220 projects
Cerebral small vessel disease and beta-amyloid deposition in subjects with mildly impaired cognition
PI: Smith, Eric E
More than one-quarter of people over age 65 will develop memory problems that impair their basic activities of life. The overall goal of our project is to understand the relationship between memory a…
PI: Poulin, Marc J
Cerebral blood flow (CBF) is highly regulated by carbon dioxide and oxygen in the arterial blood. This process becomes impaired with cerebrovascular disease processes and by aging. Aging is associate…
PI: Sauve, Yves
Age-related macular degeneration (AMD) is the leading cause of registered blindness in the elderly of the western world. Each year, 78,000 Canadians are diagnosed with AMD, a number expected to tripl…
PI: Scales, Damon C
We hypothesize that the aging of Canada's population is creating a looming crisis for our healthcare system. Elderly patients already comprise the majority of acutely ill and critically ill patients …
Maintaining the dignity of patients who are approaching death is often cited as the clinical, philosophical, and moral foundation of palliative care. Research into the sources of dignity-related dist…
PI: Lassonde, Maryse; Theoret, Hugo
Sports concussion is a major problem affecting thousands of people in North America every year. In the United States alone, close to 300,000 sports-related concussions are reported annually, though t…
PI: Martino, Rosemary; Streiner, David L
Swallowing disorders (dysphagia) are common in adult patients. There is emerging evidence that dysphagia itself can cause adverse medical outcomes. There is a three-fold increased risk for pneumonia …
PI: Parker, Alex J
As we live longer than ever before the World Health Organization predicts that neurodegenerative diseases like Amyotrophic Lateral Sclerosis, Alzheimer's, Huntington's and Parkinson's diseases will s…
In Alzheimer's disease (AD), a loss of brain cells in key brain areas is linked to memory and cognitive deficits observed in this condition. The deposition of amyloid-beta protein in the brain is a p…
PI: Joanette, Yves C; Ska, Bernadette
This research program is about how the brain reorganizes itself to support the preservation of communication abilities during successful aging. The components of communication that will be studied ar…
Stroke is a leading cause of death in Canada, yet more than 80% of Ontario patients survive. These 300,000 patients who survive each year typically live with substantial limitations and 20% are admit…
PI: Wang, Jian; Bance, Manohar L
The receptor cells (the hair cells) and neurons in mammalian ears degenerate with aging. This degeneration is enhanced by damaging factors such as noise and ototoxic drugs. Hair cell death due to agi…
PI: Bedell, Barry J
Alzheimer's disease (AD) is known to affect the blood vessels in the brain. Growing evidence points to the fact that abnormalities of the blood vessels play a major role in the development and progre…
PI: Kriz, Jasna
Stroke is the third leading cause of death in industrialized countries. Unfortunately, at present, the clinical treatments remain poorly effective. There is increasing evidence that inflammation play…
Canadian Pain Society approximates the total cost of chronic pain to the Canadian economy to be $12.5 billion per year and it is estimated that nearly 1 in 3 Canadians suffers from chronic pain, maki…
PI: Mihailidis, Alex
An older adult with Alzheimer's disease is often unable to independently complete activities of daily living (ADL) such as self- care activities, because he/she cannot remember the proper sequence of…
PI: Bravo, Gina
A growing number of older Canadians develop diseases that gradually erode their decision-making abilities. Healthcare professionals and researchers typically turn to families when decisions about hea…
PI: Carrier, Julie
The current overwhelming evidence that aging is associated with a significant increase in sleep-wake cycle complaints has important individual, social and economical consequences. Multiple factors, i…
PI: Poirier, Judes
This renewal proposal seeks to further characterize the molecular mechanisms involved in the loss of specific brain cells in common Alzheimer's disease (AD). Over the recent years, our laboratory has…
Administrative claims data are rich and provide information to study how drugs are used in the real-world, and thus also provide real-world drug safety and effectiveness data. We outline two pilot pr…