CIHR Projects
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Drug therapy is a major part of healthcare for children. While drugs are given to treat, relieve symptoms and cure disease, drugs may also cause harm. Children deserve safe medications that do not ha…
Breastfeeding is very important to the health of infants, children and mothers. Breastfeeding protects against the development of diseases in infants and children (including sudden infant death syndr…
Many young Canadian children experience poor physical, cognitive, communicative, and psychosocial development. Public health nurses have a long history of providing preventive services to families to…
PI: BĂ©rard, Anick
Although anti-infectives including antibiotics are amongst the most frequently used drugs during pregnancy, there is no agreement on the absolute risks and benefits for the mother and her child. Anti…
Changing practice behaviour: Evidence-based strategies to improve outcomes for antisocial youth.
PI: Granic, Isabela; Edmondson, Anne M
The rate of adolescents in Canada charged with violent crimes has increased by 12% in the last decade and 30% since 1991. Effective interventions are critical not only for the well-being of antisocia…
Type 1 diabetes (T1D) is one of the most chronic diseases diagnosed in children, teenagers and young adults. It is a lifelong disease where the body produces little or no insulin. Children with diabe…
PI: Blais, Lucie
The prevalence of asthma among pregnant women is between 4 to 7% and is known as one of the most frequent chronic diseases encountered during pregnancy. Concerns about teratogenicity of asthma medica…
PI: Heaman, Maureen I; Martens, Patricia J
Prenatal care is an important health service that has the potential to improve the health of pregnant women and result in better pregnancy outcomes. However, not all women receive an optimal level of…
Résumé non scientifique : Un enfant issu d'une grossesse et/ou une naissance compliquées peut être à risque de développer des maladies dans le futur, même à l'âge adulte. En effet, plusieurs études a…
PI: Garg, Amit
Living kidney donation is now the major form of transplantation in North America. For various reasons most kidney donors are women. Female donors often ask their doctors whether donation will have an…
Permanent hearing loss is one of the most common childhood disorders and interferes with the typical acquisition of speech and language and influences academic, social, and quality of life outcomes. …
PI: Librach, Clifford L; Kingdom, John C
Preeclampsia (PE) is a disease that affects 2-7% of all pregnant women and is one of the major causes of maternal and fetal morbidity and mortality throughout the world. The underlying cause for this…
Permanent hearing loss is one of the most common childhood disorders and interferes with the typical acquisition of speech and language and influences academic, social, and quality of life outcomes. …
PI: Bagli, Darius J
Our research goal is to find new drug treatments for bladder obstruction. Obstruction creates multiple health problems including incontinence, recurrent urine infection, and kidney damage, resulting …
PI: Jankov, Robert P
Pulmonary hypertension (high blood pressure in the lung) is a complication that requires medical treatment in about 1 in 500 newborn infants and commonly leads to death in the most severe cases. This…
PI: Gupta, Indra R
Our laboratory has discovered a mouse model that has a congenital urinary tract defect known as vesicoureteric reflux. In this grant, we will use this mouse model to understand the genetic basis of v…
PI: Adamson, S. Lee
The placenta is a critically important organ for successful pregnancy. In the placenta, maternal blood rich in oxygen and nutrients bathes the fetal villi. They absorb these substances and they are t…
Mechanisms of Retinopathy of Prematurity: Role of PAR-2 in restoration of retinal microvascular bed
PI: Chemtob, Sylvain
Retinopathy of prematurity (ROP) is the major serious eye disorder of the child. This condition is associated with long term complications, including strabismus, myopia, abnormal color discrimination…
A group of researchers from McMaster University is studying women who had preeclampsia (high blood pressure during the last half of pregnancy along with leakage of protein in their urine) because the…
The perception and acquisition of language and music depend critically on developing efficient brain networks for complex sound processing. The research in this proposal examines the brain's response…
It is well established that an epidemic of obesity is well underway in developed countries around the world, with enormous costs at a personal, familial and societal level. Of particular concern is t…
PI: Szatmari, Peter; Bryson, Susan E; Fombonne, Eric
The Autism Spectrum Disorders (ASD) include autistic disorder (AD), Asperger syndrome (AS), and PDDNOS and affect roughly 1 in 165 children. Based on prevalence, cost of services, reduced quality of …
PI: Leung, Peter C
Ovarian cancer is the most lethal and primary cause of death from gynecological malignancies for women in developed countries. A better understanding of the pathophysiology of this devastating diseas…
Analysis of the B-cell Lymphoma-9/Pygopus Protein complex in vertebrate body axis development
PI: Kao, Kenneth R
The penetration of the sperm cell into the dormant egg triggers the remarkable program of events that turns the egg into a miniature but living model of the adult, called an embryo. While surface obs…
PI: Deroo, Bonnie J
The most common cause of infertility in women is impaired ovulation, and although few genetic causes of infertility are known, a genetic basis for infertility is suspected. Genes associated with the …
Caring for a child with a life-limiting illness is a stressful experience that compounds the usual challenges of parenting. The negative aspects of caring for a child with a life-limiting illness are…
Motor vehicle-related pedestrian injuries are among the leading causes of hospitalization and mortality, particularly during the elementary-school years, when children are increasingly allowed to mak…
PI: Mcdougall, Janette; Wright, Virginia F
Maximizing quality of life for children and youth is a key goal of the Ontario Association of Children's Rehabilitation Services (OACRS) treatment centres. Many supports and interventions are directe…
PI: Viger, Robert S
Reproductive dysfunction is a common medical condition that affects the lives of many Canadians. Examples range from abnormalities of sexual development to male and female infertility. Research into …
Investigation of meiotic defects in infertile men undergoing assisted reproductive technologies
PI: Ma, Sai
It is estimated that 2% of men are infertile due to severe defects in sperm production. In the majority of these cases, the cause of infertility remains unknown. During spermatogenesis, cells must un…
PI: Miller, Steven P
Heart birth defects are of the most common birth defects diagnosed in Canada, affecting 1 in 100 newborns each year. Impairments in motor and cognitive development are common in children born with he…
PI: Takser, Larissa
Neurodevelopmental disabilities affect 3-8% of babies born each year in North America, with known etiology for less than 25% of those disabilities. The potential for environmental contaminants to pro…
Adolescence is a time when children with type 1 diabetes may resist parental involvement in their diabetes management but at the same time, they may neglect aspects of their self-management. Parents …
PI: Dilworth, F J
The different cell types within the human body all possess an identical DNA content. However, each cell-type has a specific subset of genes that it expresses which gives rise to its identity. Once a …