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Showing 2801-2832 of 2832 projects for "diabetes"
PI: Zhen, Mei; HĂ©on, Elise
Bardet-Biedl syndrome (BBS) is an inherited form of progressive blindness that is associated with other major health problems. These include obesity, kidney and liver failure, diabetes and learning d…
In diabetes, kidney disease can result when highly specialized cells, known as podocytes become injured. Once damaged, these podocytes can no longer help filter the blood since they allow proteins in…
PI: Prakash, Satya
Recent changes in human diet and lifestyle have resulted in a dramatic increase in number of diabetics worldwide. The continuous use of currently available synthetic drugs has associated limitations.…
PI: Marliss, Errol B
Muscle is the principle tissue with high protein content in the body, so it plays a central role in the whole body's protein balance. Insulin is the main anabolic (tissue-building) hormone, and it af…
PI: Peng, Tianqing
Diabetes is a disease. Patients' body with this disease can not properly utilize sugar (glucose). Thus, there is an increased concentration of sugar in blood of diabetic patients. There are two main …
PI: Sairam, M. R
As obesity accounts for nearly 80% of type II diabetes, a disease that particularly affects an aging population it is important to understand mechanisms that lead to expansion of the bursting bulge. …
PI: Brumell, John H
Some bacteria have the remarkable ability to invade our cells and replicate within them during infection. Such bacteria use special toxins to alter the control systems of our cells. These toxins caus…
Specialized cells of the immune system, T lymphocytes, have been trained to discriminate between harmless proteins of our own tissues, self-proteins, and dangerous proteins from pathogen agents. This…
The membrane bilayer provides a partition between intracellular and extracellular compartments of organelles and cells. Membrane proteases have evolved to allow transfer of information across this pa…
The membrane bilayer provides a partition between intracellular and extracellular compartments of organelles and cells. Membrane proteases have evolved to allow transfer of information across this pa…
One in four Canadian children is overweight or obese. Over the past 25 years, the level of overweight and obesity has doubled. This is worrying because it has long term health consequences. Childhood…
Enormous scientific advances have been made in the area of nutrition, and several diets are now advocated for the management of chronic diseases including cardiovascular diseases, diabetes and obesit…
Lipids play important roles in all cells. They are different than many other biological molecules in that they are like oils and do not mix in the aqueous environment of cells. In this way they can f…
PI: Woo, Minna N
The worldwide increase in type 2 diabetes from 30 million to 171 million between 1985 and 2000 have far surpassed the estimated forecast. Type 2 diabetes is the leading cause of heart and kidney fail…
PI: Sweeney, Gary
The current obesity epidemic is responsible for an increased incidence and decreased age of onset of type 2 (insulin-resistant) diabetes. It is therefore imperative to understand the mechanisms respo…
PI: Chan, John S
Hypertension is a medical condition in which the blood pressure is chronically elevated. Persistent hypertension is one of the risk factors for vascular diseases, strokes, heart attacks, heart and ki…
Obesity has now been identified as the principal risk factor for heart disease, the leading cause of death in Western societies. In 2004, 32.1% of all Canadian deaths were attributed to cardiovascula…
Obesity has now been identified as the principal risk factor for heart disease, the leading cause of death in Western societies. In 2004, 32.1% of all Canadian deaths were attributed to cardiovascula…
Pancreatic beta cells make insulin, which is secreted into the blood to control the levels of blood sugar/glucose. In type 2 diabetes, insulin secretion is impaired, leading to high blood glucose, a …
PI: Baldwin, Troy A
T cells are a type of white blood cell that are critical for providing protection against infections and cancer. T cells mature in an organ called the thymus. It is in the thymus where the ability of…
Each human kidney contains 1 million tiny structures called glomeruli. The glomeruli filter the blood as the first step in its purification by the kidney. Two very important blood vessels, the affere…
PI: Wassmann, Sven
Atherosclerotic diseases such as heart attack and stroke are the leading cause of death in the Western world. We investigate mechanisms that account for pathological changes in the vessel wall which …
PI: Servant, Marc
Cardiovascular disease (CVD), including heart disease, stroke and peripheral vascular disease, is the leading cause of death in Canada and in Western society. When death is not the end point, CVD jeo…
Mechanisms by which Diabetes Mellitus promotes the development and progression of atherosclerosis
Over 75% of people with diabetes will die prematurely of heart attack or stroke. The goal of our research is to; i) determine why, and ii) to find ways to prevent this from happening. We have identif…
Islet transplantation alleviates the need for daily insulin injections in Type-1 Diabetes. However, continuous immunosuppressive therapy to prevent the recipient's immune system from rejecting the is…
Canada is experiencing an epidemic of obesity that is contributing to diabetes, heart disease, and premature death. This proposal investigates why being obese causes the metabolic syndrome with a spe…
Protein metabolism and insulin resistance in cancer cachexia: a potential anabolic role of leucine
Protein loss, mostly from muscle, is very common in lung cancer and this affects the patients' physical function, response to treatment and quality of life. We propose that cancer patients are losing…
PI: Deber, Charles M
Embedded in the membranes of all living cells, membrane proteins are the molecular links between the inside and outside world. These proteins help preserve the biological structure of the cells; they…
Adolescence is a time when children with type 1 diabetes may resist parental involvement in their diabetes management but at the same time, they may neglect aspects of their self-management. Parents …
PI: Muruve, Daniel A
Kidney diseases are common in the general population. Many types of kidney disease are caused by toxins, poor circulation, diabetes and other insults. Invariably, these types of kidney injury result …
Glucagon is a hormone secreted from the pancreas that together with insulin, controls levels of blood sugar through actions on the liver. Excess glucagon action in diabetic subjects underlies the ina…
PI: Chen, Hsiao-Huei
Sensory neurons are frequently lost in patients with cancer, diabetes or HIV infection. Optimally, cell based therapies to selectively replace the missing sensory neurons will require knowledge of th…