CIHR Projects
Browse 3137 CIHR-funded research projects
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Showing 3101-3137 of 3137 projects
Diseases of the cardiovascular system, such as coronary heart disease and stroke due to atherosclerosis, are known to start in the vascular endothelium. This research laboratory has a long-term inter…
PI: Keller, Gordon M
The focus of this research proposal is to understand how to direct embryonic stem cells (ESCs) and reprogrammed pluripotential stem cells (iPSCs) to generate blood forming stem cells in a tissue cult…
PI: Feng, Qingping
Sepsis is one of the main consequences of infectious diseases and occurs in 2-11% of all hospital or intensive care unit admissions. Mortality is 20-30% in sepsis and 40-80% in septic shock. Cardiac …
PI: Peng, Tianqing
Diabetes is a disease. Patients' body with this disease can not properly utilize sugar (glucose). Thus, there is an increased concentration of sugar in blood of diabetic patients. There are two main …
PI: Funk, Colin D
Heart attacks and strokes are often caused by a series of events starting with the disruption of fatty plaques on the inner lining of blood vessel arteries. Subsequently, one of the main events is th…
PI: Funk, Colin D
Abdominal aortic aneurysm (AAA), an aberrant expansion of the largest blood vessel in the body, is a major cause of sudden death in the elderly population. This project seeks to understand the role o…
PI: Becker, Allan B; Chan-Yeung, Moira
We undertook a multifaceted intervention program during the last trimester of pregnancy and the first twelve months of life in children at high risk for the development of asthma, based on a strong f…
PI: Hamid, Qutayba A
Severe asthma is found in 10% of asthmatics but is responsible for a disproportionately high fraction of the health care budget. We have recently developed a program to identify difficult to treat as…
PI: Hill, John S
Heart disease occurs when important blood vessels become narrow or blocked and can no longer give enough blood to meet the demand of the heart. Heart disease is the leading cause of death in the West…
PI: Hui, Chi-Chung
Cardiomyopathies and arrythmias are common congenital heart diseases. The molecular basis of these diseases is not well understood but they are generally believed to involve abnormal physiological fu…
Despite advances in medical and surgical therapies, the morbidity and mortality of patients with chronic coronary artery disease and heart failure remains high. For patients who fail to improve with …
PI: Zahradka, Peter
When arteries fill with lipid because of atherosclerotic disease, blood flow can becomes severely restricted. In the case of the heart, this can lead to a heart attack. If these lipid-filled lesions …
PI: Heyland, Daren K
Every day in hospitals across Canada, frail elderly patients at or near the end of life are faced with decisions related to the use of life support machines. In a recent survey carried out at several…
G protein coupled receptors (GPCRs) are the single largest family of cell surface proteins involved in signal transduction, and represent one of the major pharmaceutical targets. Action of drugs and …
Detection of Acute Kidney Injury after Abdominal Aortic Aneurysm Repair: Role of New Biomarkers
PI: Garg, Amit
About 2% of adults will develop an aneurysm or 'ballooning' of the aorta, the main blood vessel supplying the body. These aneurysms usually form close to the vessels which supply blood to the kidneys…
PI: Chan, John S
Hypertension is a medical condition in which the blood pressure is chronically elevated. Persistent hypertension is one of the risk factors for vascular diseases, strokes, heart attacks, heart and ki…
PI: Peever, John H
Obstructive sleep apnea (OSA) is the most common and severe sleep disorder. It affects more than 18 million North Americans and causes disturbed sleep, excessive sleepiness, high blood pressure, clog…
PI: Peever, John H
Obstructive sleep apnea (OSA) is the most common and severe sleep disorder. It affects more than 18 million North Americans and causes disturbed sleep, excessive sleepiness, high blood pressure, clog…
Brain Mechanisms Determining Sympathetic Hyperactivity and Cardiac Dysfunction in Rats Post MI.
PI: Leenen, Frans H
Heart failure is a progressive disease, slowly, but surely disabling the patient. In recent years, it has become clear that besides the initial abnormality in the heart (eg heart attack) increased ac…
PI: Bacon, Simon L
Asthma is a chronic disorder of the airways primarily driven by increased airway inflammation, and is an escalating medical problem in Canada. For example, between 1994 and 2001 there was a 40% incre…
PI: Bacon, Simon L
Asthma is a chronic disorder of the airways primarily driven by increased airway inflammation, and is an escalating medical problem in Canada. For example, between 1994 and 2001 there was a 40% incre…
Each human kidney contains 1 million tiny structures called glomeruli. The glomeruli filter the blood as the first step in its purification by the kidney. Two very important blood vessels, the affere…
PI: Wassmann, Sven
Atherosclerotic diseases such as heart attack and stroke are the leading cause of death in the Western world. We investigate mechanisms that account for pathological changes in the vessel wall which …
A Phase 1, First-in-Man Trial of Intracoronary Collagenase Therapy For Chronic Total Occlusions
Coronary arteries that have been totally blocked for 6 weeks or longer, are called chronic total occlusions (CTO). CTO are found in 30% of all coronary angiograms and frequently cause significant car…
PI: Servant, Marc
Cardiovascular disease (CVD), including heart disease, stroke and peripheral vascular disease, is the leading cause of death in Canada and in Western society. When death is not the end point, CVD jeo…
The kinins are hormone-like substances generated from blood, but also potentially from the cells that constitute the blood vessels. Two types of receptors are activated by kinins: the B2 receptors ar…
PI: Keshavjee, Shaf
Lung transplantation (LTx) has become life saving therapy for patients suffering from many types of end-stage lung diseases (e.g. emphysema, pulmonary fibrosis, pulmonary hypertension and cystic fibr…
Heart malformations present at birth represent the single largest class of birth defects in humans, and are the leading cause of death in infants under one year old. Despite significant advances in o…
PI: Martin, James G
Asthma is caused by factors in the environment that act on the susceptible host, creating constriction of the airways or bronchospasm. The airways undergo changes after allergen exposure in sensitize…
PI: Meade, Maureen O; Ferguson, Niall D
Acute respiratory distress syndrome (ARDS) is a common and catastrophic complication of critical illness related to burns, motor vehicle accidents, or overwhelming infection. ARDS kills 40-70% of aff…
PI: Allan, David S
This research addresses the use of blood stem cell products to restore blood flow into damaged tissues. Blood stem cell products used for transplantation include bone marrow, peripheral blood stem ce…
The acid-base balance of organisms, including humans, must be carefully regulated. Both the pH (a measure of the concentration of acid) of cells and of the fluids that bathe them, including blood, ar…
PI: Rola-Pleszczynski, Marek; Stankova, Jana
Le PAF est une petite molecule bioactive qui attire et active les leucocytes. Il joue un role important dans plusieures maladies inflammatoires et allergiques, telles l'asthme et le choc septique. So…
Heart failure (HF) affects 2% Canadians and is now the second leading cause of death. It is therefore important to identify potentially treatable factors that could improve the outcome of this diseas…
PI: Janssen, Luke J
A large percentage of Canadians suffer from coronary artery disease; coronary artery bypass graft (CABG) surgery is the treatment of choice for these people. Although the intent of performing CABG is…
Heart failure is the inability of the heart to pump adequate blood and oxygen to supply the needs of the body. Patients with heart failure have difficulty breathing, get tired easily and often have s…
Coronary artery disease, leading to chest pain and heart attacks, is the leading cause of death in the developed world. The damaged heart muscle is replaced with scar tissue resulting in diminished a…