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PI: Janssen, Luke J
A large percentage of Canadians suffer from coronary artery disease; coronary artery bypass graft (CABG) surgery is the treatment of choice for these people. Although the intent of performing CABG is…
PI: Kaplan, Gilaad G
Crohn's disease and ulcerative colitis are incurable diseases that affect a patient's gut. The causes of these diseases are not known. However, it most commonly occurs in industrial countries such as…
Mitochondria are extremely dynamic organelles undergoing constant double membrane fusion and fission reactions. The control and mechanisms involved to regulate this activity are currently of great in…
PI: Rathee, Satyapal; Fallone, Biagio G
Nearly half of the cancer patients will receive radiation therapy for their treatment. Image guided radiotherapy promises to precisely align the diseased volume with the radiation beams in real time,…
Glucagon is a hormone secreted from the pancreas that together with insulin, controls levels of blood sugar through actions on the liver. Excess glucagon action in diabetic subjects underlies the ina…
PI: Brown, Grant W
Before a cell can grow and divide it must duplicate its DNA. In this way, when a cell divides to form two daughter cells, each of the daughters will receive the full complement of genes required for …
Cardiovascular disease (CVD) is becoming more common among the First Nations population in Canada, resulting in an increasing burden of illness and death. Hospital admission rates for CVD are stable …
Biomarkers of Disease Progression in Parkinsonism: Magnetic Resonance Imaging and Spectroscopy
Parkinson's disease (PD) is a progressive neurological disorder that affects the means by which the brain controls movement. Treatments that are currently available are reasonably effective at improv…
Heart failure is the inability of the heart to pump adequate blood and oxygen to supply the needs of the body. Patients with heart failure have difficulty breathing, get tired easily and often have s…
PI: Dilworth, F J
The different cell types within the human body all possess an identical DNA content. However, each cell-type has a specific subset of genes that it expresses which gives rise to its identity. Once a …
PI: Chen, Hsiao-Huei
Sensory neurons are frequently lost in patients with cancer, diabetes or HIV infection. Optimally, cell based therapies to selectively replace the missing sensory neurons will require knowledge of th…
It is generally thought that dendritic cells are playing a pivotal role in HIV-1 transmission as they serve as the first potential targets for virus infection. The central objective of our work is to…
PI: Dumont, Eric C
In spite of intense efforts in research, as well as clinical and field interventions to prevent and treat drug addiction, this health problem is still devastating and worse, is still growing. In part…
PI: Barrett, Sean P
One issue that may hinder our understanding of illicit drug addiction is the tendency for drug users to administer multiple substances at a time, a phenomenon known as simultaneous polysubstance use …
Environmental Scan and Stakeholder Consultation on Electronic Personal Health Records in Canada
PI: Archer, Norman P; Mckibbon, Kathleen Ann; Straus, Sharon E; Willison, Donald J
The Canadian healthcare system is moving towards a reduction of operating cost by an increased emphasis on caring for the elderly and patients with chronic diseases of all ages at home instead of ins…
The implementation of DNA repositories has brought to the forefront certain ethical and legal challenges surrounding genomic research. One such challenge is related to the regulation and control of t…
PI: Speechley, Mark; Adams, Paul C
The use of genetic tests to identify people who face an increased disease risk is growing in Canada. The social marketing of gene tests contains two misleading messages: i) the prices for tests are l…
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The threat posed by the emergence of the highly pathogenic strain of influenza A has been met with an abundance of preemptive scientific research to prepare for a pandemic. However, it is equally imp…
National network for characterization of influenza virus evolution and antiviral drug susceptibility
PI: Boivin, Guy
Influenza A viruses evolve constantly and rapidly leading to seasonal flu epidemics and occasional but devastating flu pandemics. There is thus a need to rapidly identify new emerging influenza strai…
PI: Pedlar, David J
Workplace Reintegration of Veterans with Mental Disorders Mental health has special significance in the Canadian military and Veteran (former military) populations. For example, the rate of depressio…
PI: Leblanc, Vicki R; Regehr, Cheryl
Emergency services work is characterized by high stress situations requiring immediate intervention and by exposure to distressing events that are outside the experience of the general public. Dispat…
Mindfulness-based Cognitive Therapy for the prevention of depressive relapse in the workplace
PI: Lau, Mark A
Depression is among the most costly of all health problems to employers. This is particularly true for the health service sector, which typically employs mostly women as depression is twice as preval…
PI: Lam, Raymond W
Clinical depression and anxiety in employees, managers and executives (workplace depression) is a significant burden to society from both human resource and economic viewpoints. Depression is now a l…
Coronary artery disease, leading to chest pain and heart attacks, is the leading cause of death in the developed world. The damaged heart muscle is replaced with scar tissue resulting in diminished a…