CIHR Projects
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While acute pain is uncomfortable and perhaps menacing, it serves a useful purpose in warning an organism of impending harm. In contrast, chronic pain serves no useful purpose, is usually out of prop…
The major objective of this proposal is to identify microRNA differences in prefrontal cortex and hippocampus of depressed suicides compared to controls. MicroRNA are small, noncoding RNA molecules t…
PI: Lau, Mark A
Depression is a potentially lifelong illness with a high relapse risk. The proposed study extends our research program studying the role of cognitive reactivity as a risk factor for depressive relaps…
PI: Ansari, Daniel
Most of us deal with numbers efficiently, oftentimes without being aware of it. A good example is reading a newspaper article. In the process of doing so, you will encounter several pieces of numeric…
PI: Malla, Ashok K; Joober, Ridha
The generally poor long term outcome in schizophrenia and related psychotic disorders is established relatively early in the first five "critical" years after onset. Specialized Early Intervention (S…
PI: Anisman, Hymie
Stressful events are known to promote major depressive disorder, and the occurrence of such an outcome is more pronounced among individuals that had previously experienced major life stressors. Indee…
PI: Gilron, Ian
Pain is a major public health problem affecting one-third of the population and costing $165 billion/year in North America alone. Individual pain-relievers provide incomplete relief and can often pro…
PI: Lam, Tania
Although many people who had a stroke can get better and walk again, there are still problems with walking that limit their ability to fully take part in many daily activities. Up to now, stroke rese…
Biomarkers of Disease Progression in Parkinsonism: Magnetic Resonance Imaging and Spectroscopy
Parkinson's disease (PD) is a progressive neurological disorder that affects the means by which the brain controls movement. Treatments that are currently available are reasonably effective at improv…
PI: Chen, Hsiao-Huei
Sensory neurons are frequently lost in patients with cancer, diabetes or HIV infection. Optimally, cell based therapies to selectively replace the missing sensory neurons will require knowledge of th…
PI: Dumont, Eric C
In spite of intense efforts in research, as well as clinical and field interventions to prevent and treat drug addiction, this health problem is still devastating and worse, is still growing. In part…
PI: Barrett, Sean P
One issue that may hinder our understanding of illicit drug addiction is the tendency for drug users to administer multiple substances at a time, a phenomenon known as simultaneous polysubstance use …
PI: Pedlar, David J
Workplace Reintegration of Veterans with Mental Disorders Mental health has special significance in the Canadian military and Veteran (former military) populations. For example, the rate of depressio…
PI: Leblanc, Vicki R; Regehr, Cheryl
Emergency services work is characterized by high stress situations requiring immediate intervention and by exposure to distressing events that are outside the experience of the general public. Dispat…
Mindfulness-based Cognitive Therapy for the prevention of depressive relapse in the workplace
PI: Lau, Mark A
Depression is among the most costly of all health problems to employers. This is particularly true for the health service sector, which typically employs mostly women as depression is twice as preval…
PI: Lam, Raymond W
Clinical depression and anxiety in employees, managers and executives (workplace depression) is a significant burden to society from both human resource and economic viewpoints. Depression is now a l…