CIHR Projects
Browse 3998 CIHR-funded research projects
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PI: Sayani, Ambreen
Lung cancer is the most commonly diagnosed cancer in Canada and is responsible for a quarter of all cancer-related deaths in the country. Screening for lung cancer using tools such as a CT scan can a…
PI: Hay, Kevin A; Hawrysh, Terry A; Kekre, Natasha; Krueger, Joerg; Li, Amanda; Szwajcer, David
Chimeric antigen receptor (CAR)-T cells targeting CD19, a marker on B cell cancers, have led to meaningful and durable remissions for patients with relapsed or refractory B-cell acute lymphoblastic l…
PI: Kekre, Natasha; Bredeson, Christopher; Hawrysh, Terry A; Fergusson, Dean A; Hay, Kevin A; Holt, Rob; Quizi, Jennifer L; Thavorn, Kednapa
Patients with some forms of blood cancer that do not respond to standard therapies have a particularly poor chance of survival. Chimeric Antigen Receptor modified T cells (CAR-Ts) are a powerful new …
PI: Elimova, Elena; Goodwin, Rachel A; Lim, Howard; O'Callaghan, Christopher J; Tu, Dongsheng
Patients with advanced stomach or esophageal cancer that is not treatable by surgical removal and which has high amounts of human epidermal growth factor receptor Type 2 (aka HER2) on the surface of …
PI: David Malkin, James Whitlock; Co-Dyre, Adrienne; McIntosh, Keith A; Denburg, Avram E; Deyell, Rebecca J; Duval, Michel; Jabado, Nada; Marjerrison, Stacey L; Rayar, Meera; Tsimicalis, Argerie
Cancer is the leading cause of disease-related death in children and adolescents beyond the newborn period. In Canada, ~10,000 children are living with cancer and ~1500 new cases are diagnosed each y…
PI: Leese, Jennifer
The Canadian Cancer Society (CCS) is the largest national charitable funder of cancer research in Canada. With a mandate to improve the health of people living with cancer in all communities across C…
Despite there being a wealth of evidence that exercise therapy is beneficial for cancer patients, our provincial Cancer Care Program does not offer sustainable exercise programming tailored for patie…
PI: Alduaij, Waleed
Aggressive B-cell lymphoma is a cancer of the immune system that affects 4000 Canadians annually. Despite available treatments, one-third of afflicted patients die of their disease. This project will…
PI: Vanner, Robert J
Clonal hematopoiesis is a common condition where a mutant stem cell excessively contributes to blood. We discovered that one type of clonal hematopoiesis activates the immune system to help patients …
Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Whereas, some patients can be cured with surgery alone, a significant number will need complimentary treatments sinc…
PI: Gallo, Marco
PFA ependymoma is an incurable brain tumor affecting mostly infants and young children. Unlike other tumor types, PFA has few mutations in genes, and only rarely the same gene is mutated in more than…
Childhood cancer while rare is nevertheless responsible for the most disease-related deaths in childhood. For children whose cancers relapse after treatment or for whom those initial treatments are u…
PI: Khalvati, Farzad; Ertl-Wagner, Birgit B
Pediatric low-grade gliomas (pLGG) are the most common brain tumours in children. With surgical excision as the main treatment, and chemotherapy and radiation as additional treatment options, death f…
Background and Significance: Human papillomavirus (HPV) related head and neck cancer is the fastest rising cancer in North America. The standard of care treatment is high dose chemotherapy with high …
PI: Purdie, Thomas G; Berlin, Alejandro; Mcintosh, Christopher J
Radiotherapy is an essential part of cancer treatment. Although 50% of curative-intent cancer therapy involves radiotherapy, the availability of radiotherapy varies greatly as resource constraints ar…
PI: Zadeh, Gelareh
Meningiomas are the most common brain tumour and the WHO grade and extent of resection guide adjuvant radiotherapy (RT). However, up to 40% of all meningiomas progress despite RT. Recently, we develo…
PI: Benard, Francois
CXCR4 is a protein in humans that is observed in high abundance in more than 20 different types of cancer. This protein has been shown to be involved in homing of cancer cells to the bone marrow, and…
PI: Cullis, Pieter R
Chimeric Antigen Receptor (CAR) T cell therapy is relatively new and exciting form of cancer therapy which uses a patients own re-programmed immune cells to specifically target and destroy cancer cel…
PI: Culos-Reed, S.Nicole; Wurz, Amanda J
Physical activity is safe and enhances well-being among children and adolescents diagnosed with cancer. We co-created, with key stakeholders, a tailored, 1:1, online physical activity intervention ca…
A tumor marker called GD2 is present almost exclusively on the surface of tumors, such as 80% of human melanoma. GD2 activates pathways that give tumors a growth advantage, and causes immunosuppressi…
External beam radiotherapy (EBRT), brachytherapy boost and androgen deprivation therapy (ADT) is the evidence-based standard of care for unfavourable risk (high-tier intermediate or high risk) prosta…
The long-term goal of our research program is to understand the molecular recognition process that takes place between a special type of protein involved in cancer development and drug molecules. Spe…
PI: Evgin, Laura E
T cells patrol the body using their T cell receptors (TCR) to seek out cells which display evidence of intracellular pathogens or cancers. In order to focus their attention on specific cancer antigen…
PI: Chen, Guojun
Immune checkpoint blockade (ICB) is a new type of cancer therapy that works by strengthening immune systems to attack tumor cells. Several ICB drugs have been approved for treating solid cancers and …
PI: Ignea, Codruta
Taxol is one of the best anticancer drugs ever developed, used against ovarian, breast, lung and other cancers. Its effectiveness combined with anticipated further therapeutic applications has genera…
PI: Awadalla, Philip; Abelson, Sagi; Alvi, Riaz; Bhatti, Parveen; broet, philippe; Dummer, Trevor J; Kirsh, Victoria; Mclaughlin, John R; Shen-Tu, Grace; Sweeney, Ellen; Turner, Donna C; Urquhart, Robin L
The global burden of cancer is a major public health crisis that has been deeply exacerbated by the COVID-19 pandemic. Since the World Health Organization declared COVID-19 a pandemic on March 11 202…
Using AI to predict the presence of occult invasive carcinoma following diagnosis of DCIS on biopsy
PI: Martel, Anne L; Nofech-Mozes, Sharon
The number of women diagnosed with Ductal Carcinoma In Situ (DCIS), a non-invasive form of breast cancer, has increased rapidly since the introduction of breast screening programs. DCIS is regarded a…
PI: Done, Susan J
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with more deaths occurring within the first 5 years after diagnosis than for other subtypes. Breast cancers are ro…
Acute myeloid leukemia (AML) is characterized by the uncontrolled growth of immature bone marrow cells. Across Canada, every year there are approximately 1500 new cases of AML and 1000 deaths, making…
PI: Parulekar, Wendy R; Welch, Stephen A
Endometrial cancer (EC) is the most common gynecologic malignancy and the fourth most-commonly diagnosed cancer in Canadian women. The incidence of EC is rising worldwide. Based on 2021 Canadian Canc…
PI: Tremblay, André
Cancers related to the reproductive organs, such as breast, uterus, and ovarian cancers, continue to be the leading forms of cancer in terms of incidence in Canadian women. Of these, ovarian cancer l…
PI: Mak, Tak W
Each year, over 20 000 Canadians are diagnosed with blood cancers. Many of these cancers are very difficult to treat. These tumors are caused by defects in genes that control the development of blood…
PI: Copeland, John W
For many types of cancer it is the spread of the tumor away from its original location that ultimately proves lethal. This process, called metastasis, is driven by cell motility (movement). My labora…
Gliomas are the most common brain tumor and the most common cause of cancer-related morbidity and mortality in adolescent/young adults (AYA). While children are now successfully molecularly matched t…
Targeting lung microbiome for developing early detection and intervention strategies for lung cancer
PI: Lam, Wan L
Bacteria residing in the human lung may contribute to cancer development. This study determines whether specific changes in bacterial composition in the airways is indicative of cancer development an…
PI: Kuzmin, Elena
Cancer is associated with an accumulation of alterations in genes that confer the ability of cancer cells to grow uncontrollably. These alterations can contribute to increased deleterious function or…
PI: Yang, Hua; Benard, Francois
Radioactive atoms that emitting alpha-particles, so called alpha-emitters, are powerful weapons for late-stage cancer treatments. Those radionuclides can deposit a lot of energy in a short distance. …
PI: Leong, Hon Sing; Lim, Christopher
Early detection and diagnosis of prostate cancer still needs significant improvement. Too many men are erroneously submitted to an invasive biopsy procedure that will reveal no evidence of cancer. Mo…
PI: Rushton-Marovac, Moira K; Cescon, David W; Seymour, Lesley
Breast cancers sensitive to the female hormone estrogen (ER+) are the most common subtype of breast cancer, and represent a majority of cases of incurable metastatic disease in Canada and worldwide. …
Our research explores the mechanisms regulating protein synthesis (translation) in cancer cells and how these can be exploited for therapeutic purposes. Specifically, we focus on a key regulator of t…
Prostate-targeted PET/TRUS dual-modality imaging system for diagnosis and image-guided biopsy.
PI: Reznik, Alla
Prostate cancer (PCa) remains the most commonly diagnosed solid organ malignancy in men. However, unlike other more aggressive cancers, prostate cancers exhibit a broad range of biology ranging from …
PI: Kim, Tae-Hee
Colon cancer is one of the most common and deadly cancers in Canada. Approximately, one in 13-16 people in Canada is expected to develop colon cancer during their lifetime, and more than 20 people di…
Novel contrasting functions of RNF168 and RNF169 in breast cancer and therapeutic implications.
PI: Hakem, Razqallah
Understanding the root causes of breast cancer is essential to improve its therapy. Despite advances made in the past decades in identifying mechanisms that drive breast cancer development, there is …
PI: Nabi, Ivan R
The cell is surrounded by a lipid membrane and contains multiple, distinct organelles, also surrounded by membranes. Different organelles contact each other, forming nanometer (nm)-scale membrane con…
PI: Saibil, Samuel D
The treatment of cancers, especially blood cancers, with the transfer of genetically-engineered T cells has demonstrated great promise. Unfortunately, many barriers remain to be overcome to allow pat…
PI: Poirier, Donald
There is strong evidence converging to the key role of cholesterol in pancreatic cancer. The development of a drug acting via the disturbance of cholesterol homeostasis (balance) seems very promising…
Prostate cancer (PCa) is the most common cancer type in males in Western countries. Following surgery or radiotherapy, standards of care for recurrent PCa are to block the androgen receptor (AR), eit…
Glioblastoma (GB) is the most malignant primary brain tumor in adults. The present standard of care includes maximal surgical removal of the tumors followed by treatment with Temozolomide (TMZ) and i…
PI: Brown, Jeremy A
Most traditional methods for treating tumours, such as radiation therapy or even traditional focused ultrasound, work by heating the tumour until the cancer cells die. Focused ultrasound therapy with…
As cancer grows and progresses, tumor cells have increased demand for nutrients and this need is met by altering the metabolic activity. Indeed, recent studies have shown that the tumor cells have re…