CIHR Projects
Browse 1992 CIHR-funded research projects
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Showing 1-50 of 1992 projects
PI: Ibarra Moreno, Carlos A; Pawliszyn, Janusz B
Malignant hyperthermia (MH) is a dangerous reaction to certain anesthetics, heat or exercise that can be fatal if left untreated, caused by an inherited dysregulation of calcium inside muscle cells. …
Chemo/radiation is standard therapy for most cancers, making the long-term consequences of radiation exposure a significant concern, particularly in childhood cancer survivors. The effects of chemo/r…
PI: Cowan, Kyle
While skeletal muscle has an extraordinary capacity to regenerate in healthy individuals following damage, there is a dramatic impairment in regenerative potential in Duchenne muscular dystrophy (DMD…
Osteoarthritis (OA) is one of the most common joint diseases in the world, affecting more than 6 million Canadians and costing $11 billion to the Canadian health care system in 2016. People affected …
PI: Kapoor, Mohit
Osteoarthritis (OA) is a progressive, degenerative disease of the joints, with the knee most commonly affected. Patients with OA experience significant pain, stiffness and loss of quality of life. Av…
PI: Rabbani, Shafaat A; Szyf, Moshe
Breast cancer metastasis to distant organs in general and to the skeleton in particular are a major cause of cancer associated morbidity and mortality. These patients are generally in advanced stages…
Total hip and knee replacements (TJR) for osteoarthritis are common orthopaedic procedures performed in Canada. Waits for these procedures are already lengthy, and the COVID-19 pandemic has further d…
PI: Velly, Ana Miriam; Allison, Paul J; Bhullar, Rajinder P; Chandad, Fatiha; Filiaggi, Mark J; Mathu-Muju, Kavita; Matthews, Debora C; Moreau, Alain; Papagerakis, Petros; Quiñonez, Carlos R; Sharifzadeh-Amin, Maryam; Siqueira, Walter L
Oral health is a major contributor to the overall health and well-being of Canadians. Poor nutrition can result from tooth loss and decay, and a number of oral health ailments can seriously reduce on…
PI: Dowling, James
Centronuclear myopathy (CNM) is a childhood muscle disease associated with significant disabilities, including respirator and wheelchair dependence, and early mortality. CNMs are defined by character…
PI: Wong, Ivan
The human shoulder has a large range of motion and as such is vulnerable to dislocations. Dislocations are commonly underestimated and are burdensome for individuals, causing pain, bone loss, stiffne…
PI: Birmingham, Trevor B; Appleton, Thomas C; Bryant, Dianne M; Giffin, James R; Hunt, Michael A; Moyer, Rebecca
Knee osteoarthritis (OA) is a leading cause of pain and disability globally. It currently affects over 4.4 million Canadians and the number is growing rapidly. There is currently no cure for OA, and …
PI: Vinet, Evelyne
With recent advances in lupus treatment, the vast majority of affected women can now consider pregnancy. However, pregnant women with lupus still face an unacceptably high risk of maternal and fetal …
PI: Graf, Daniel
Osteoarthritis is a debilitating, progressive disease affecting cartilaginous tissues, such as the knees and spine. Currently no cure exists. We recently discovered that cartilage can change its prop…
There are many diseases that result in an increase in the amount of extracellular matrix, making the skin hard and inelastic. Among these diseases, scleroderma and hypertrophic scars are two disablin…
PI: Haglund, Lisbet A; Ouellet, Jean A
Adolescent Idiopathic Scoliosis (AIS) is a curvature of the spine leading to a three-dimensional (3D) deformity, which affects 2-4% of children between 10-18 years of age. Clinically, patients with A…
PI: Kandel, Rita A
Degeneration of the intervertebral disc can result in pain, neurological symptoms and difficulty in performing many of the acts of daily living. This disease is so common that approximately 1 in 50 C…
PI: Willie, Bettina M; Rauch, Frank
Osteogenesis imperfecta is a rare disorder that results in frequent fractures and often requires orthopedic interventions. Our clinical studies show that the periosteal circumference is consistently …
PI: Herzog, Walter
Obesity is associated with an increased risk for cardiovascular diseases, diabetes, and metabolic syndrome. Recently, we discovered that obesity is also associated with muscle, bone, and joint degene…
PI: Thomas, Megan M
Inflammatory arthritis affects many people in Canada and usually requires lifelong treatment. Patients with inflammatory arthritis have different health outcomes, and many of these differences are be…
PI: Beauchamp, Marla K; Montero Odasso, Manuel M; Saunders, Stephanie; Sibley, Kathryn M
With an aging population, there are increasing concerns over health system capacity. Falls are a leading cause of hospitalization among older adults in Canada. Falls contribute to over $8.7 billion(C…
PI: Rozenberg, Dmitry; Logan, Sherrie; Mathur, Sunita
Solid organ transplantation (SOT) is a life saving procedure for many Canadians with end stage organ dysfunction. The main goals of SOT are to improve quality of life, physical function and daily act…
PI: Lacaille, Diane V; Koehn, Cheryl L; Bansback, Nicholas; Barber, Claire E; Li, Linda C
The current way of delivering care for people living with inflammatory rheumatic diseases (IRD) does not meet patients' needs, is outdated by 2022 standards, does not efficiently use the very effecti…
PI: Kellett, Peter; Da Silva, Keith; Kokaram, Denise; Mathu-Muju, Kavita; Nzekwu, Emeka; Sharifzadeh-Amin, Maryam
Access to oral health services is one of the many areas of health care inequality evident in the Canadian health care system. Using a novel social entrepreneurial model, Nation's Dental (ND) has esta…
PI: Li, Linda C; Liu-Ambrose, Teresa Y
What is a "healthy 24-hour day"? According to the new Canadian 24-hour Movement Guidelines, a healthy day includes a mix of physical activity, several hours of light activities such as standing or sl…
Bone cancer in the leg is most commonly treated with extensive reconstructive operations with the goal of saving the leg and avoiding amputation. These complex operations are associated with a high r…
PI: Affoo, Rebecca H
Oral health is a vital component of health and well-being. The consequences of poor oral health extend far beyond the mouth and include reduced quality of life, malnutrition, and the development of s…
PI: Gong, Siew-Ging
Tooth cavities, or dental caries, is the world's leading chronic disease. To fight against caries, we propose the use of specific "friendly" or probiotic bacteria that can kill cavity-causing bacteri…
PI: Hitzig, Sander L; Mackay, Crystal J; Mayo, Amanda; Miller, William C; Zidarov, Diana
Limb loss can negatively affect individuals' physical and mental health and their quality of life. In Canada, we have limited information about the size, scope, and impact of amputations to inform de…
PI: Stinson, Jennifer N; Ouellette, Carley
Immersive technologies (IT) such as augmented and virtual reality are promising tools to treat pain in both children and adults. Most of our knowledge of how IT work comes from acute (short lasting) …
National Pain Education Symposium: Building a network of educators to improve pain care and outcomes
PI: Sud, Abhimanyu
An estimated 8 million, or one in four Canadians suffer from chronic pain, costing the Canadian economy roughly $40 billion in 2019. Unfortunately, a gap exists between pain research and clinical pra…
PI: Manske, Sarah L
Rheumatoid arthritis (RA) is a common condition that can result in the presence of bone erosions, or holes within the bone, due to swelling in the joints. These erosions can lead to lower bone qualit…
Low back pain (LBP) is usually a long-term condition with episodes of improvement, remission, and recurrence. There is evidence that long term exercise combined with education and self-management is …
PI: Thombs, Brett D; Nassar, Elsa-Lynn
Systemic Sclerosis (scleroderma; SSc) is a rare musculoskeletal and skin disease characterized by thickening of the skin and fibrosis of internal organs. The burden and impact of SSc on quality of li…
PI: Rampersaud, Y. Raja; Groe, Silvana
Background: Low back pain (LBP) is the most common cause of chronic pain and disability around the world. Access to evidence-based LBP care from providers that work together and put the patient at th…
PI: Sale, Joanna E
A fragility fracture happens after a slip, trip, or fall from standing height or less (e.g. slipping on ice and breaking a wrist). Over 131,000 Canadians have one of these fractures every year. This …
PI: Logsetty, Sarvesh; Spiwak, Rae
Background: Alcohol use is one of the world's leading causes of disease and injury. Over 5.2 million people die worldwide yearly due to alcohol-related injuries. While there is growing information on…
PI: Leask, Andrew C
Fibrotic diseases such as scleroderma have limited therapeutic options. These diseases are characterized by extensive scar tissue deposition. The cells (fibroblasts) within the scar are subject to en…
The cells in our cardiac and skeletal muscle are highly specialized, displaying distinct shapes. These shapes are absolutely required for normal function, and are determined by the various proteins t…
PI: Giangregorio, Lora Marie; Alexander, Edward W; Hoshing, Natalie; Kingswood, Andrea; Vincent, Andrea; Straus, Sharon E; Walsh, Rachel L
Impaired mobility, social isolation and chronic health conditions can compromise health and wellbeing in older adults. There is strong evidence that meeting Canada's 24-Hour Movement guidelines, by g…
PI: Buckley, David N; Hudspith, Maria; Raymond, Vincent; Beaudry, Hélène; Birnie, Kathryn A; Bonin, Robert P; Bosma, Rachael L; Choinière, Manon; Gilron, Ian; Iorio, Alfonso; Latimer, Margot A; Lavis, John N; MacDermid, Joy C; Noel, Melanie E; Poulin, Patricia A; Presseau, Justin; Rash, Josh A; Stinson, Jennifer N; Sylliboy, John R
We will establish a national network to mobilize knowledge about pain to improve public awareness of pain, improve access to care and appropriateness of care, provide organizations with the best know…
PI: Lim, Changhyun
Periods of reduced physical activity (i.e., muscle disuse) caused by many clinical scenarios, such as hospitalization, a limb cast following a fracture, or joint replacement surgery, lead to a profou…
Muscle contraction underlies our every heartbeat, breath, and movement. For muscles to contract, an electrical signal from the brain must be converted to a chemical signal (calcium) in muscle cells, …
PI: Hamer, Mark
Skeletal muscle's oft-noted capacity for regeneration is severely diminished in cases of traumatic injury that result in volumetric muscle loss (VML). This type of injury commonly affects people invo…
Lower extremities torsional abnormalities: Improving management through evidence-based research
PI: Gagnon, Marianne
Knee pain is common, affecting 29% of adolescents. One of the underlying causes is a torsional deformity of the tibia and/or femurs. This has been termed "lower extremities torsional abnormalities", …
Evaluating Senolytics as preventative treatment option for Lower Back Pain in SPARC-null mice
Intervertebral discs (IVD) are rings of cartilage found in the spine between the vertebrae. Their degeneration is one of the major causes of back pain, a condition that represents a serious socio-eco…
PI: Marmura, Hana S
Anterior cruciate ligament (ACL) injuries are among the most common musculoskeletal injuries (~200,000/year), especially in young active individuals. ACL injuries often result in reduced quality of l…
Localized delivery of bFGF and periostin within a multi-scaffold system for periodontal regeneration
PI: Guo, Chengyu
Red and swollen gums? Most people think this condition is not a big deal; however, when left unattended, swollen gums can progress and cause irreversible damage to the boney architecture underneath t…
After surgery, some patients experience pain that lasts for a long time, known as chronic post-surgical pain (CPSP). People who have this type of pain often report that it negatively affects aspects …
Lumbar Spinal Stenosis (LSS) is a painful condition of the lower back. It is caused by narrowing of the spinal canal that holds the spinal cord, spinal nerves and blood vessels. This narrowing may le…
Multiple sclerosis (MS) can be a debilitating disease; however, exercise can combat disease progression. Many people with MS report having a most affected limb and a less symptomatic (preferred usage…