CIHR Projects
Browse 1999 CIHR-funded research projects
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Showing 1-50 of 1999 projects
The Canadian Nutrition Society is Canada's leading society for nutrition professionals. As an embedded Fellow, I will work with the Canadian Malnutrition Taskforce-their flagship initiative-to suppor…
PI: Nadeau-Fredette, Annie-Claire; Kilpatrick, Kelley; Tennankore, Karthik K
Quality of life is a priority research outcome for patients with advanced chronic kidney disease. When patients are treated with dialysis, their quality of life is often decreased, with levels consid…
PI: Chan, John S
High blood sugar and high blood pressure are major risk factors in the development of heart and kidney diseases, including stroke, heart attacks and kidney failure. In the kidney, blood passes throug…
PI: Martel, Guillaume; Fergusson, Dean A
Patients who suffer from colorectal cancer that has spread to the liver (metastases) can be treated with liver surgery. Liver surgery is the most effective treatment in improving survival for this di…
Skeletal muscle energetics and metabolic programming in treatment -sensitive and -resistant obesity
The causes of obesity are complex and currently available treatments are often not effective. Why some people are more at risk than others for obesity and obesity-related diseases is not well underst…
When infants are exposed to perturbed nutrition shortly after birth, their metabolism can be altered permanently. For example, if infants are premature or ill at birth, they may require intravenous n…
PI: Metherel, Adam
Young women have higher omega-3 polyunsaturated fatty acid (PUFA) status compared to men, particularly docosahexaenoic acid (DHA), and although this may be due to faster rates of DHA synthesis, this …
Cardiovascular disease (CVD) is the second leading cause of death in Canada, affecting ~2.4 million adults age 20 y and over. Several studies have associated CVD such as coronary heart disease (CHD) …
PI: Shah, Baiju R; Mulder, Carol
Nearly 2½ million people are affected by diabetes in Canada, but rates among First Nations people are much higher compared to other people in Canada. We recently completed a collaborative project bet…
Obesity is a major global health concern, especially in Western society where it is estimated that 65% of the population is overweight. Obesity is a major risk factor for other disorders, including d…
Our vision is to establish a complete understanding of the biology of human beta cells, the cells that make and secrete insulin after a meal. The inability to produce enough insulin results in diabet…
PI: Advani, Andrew
Kidney disease is one of the most devastating complications of diabetes. We urgently need new treatments. Sometimes kidney disease in diabetes develops gradually over years. This is called chronic ki…
Gut diseases have a huge impact on the Canadian health care system cost. Indeed, Canada has among the highest rates of intestinal inflammatory bowel diseases (IBD) in the world, with approximately 30…
Cardiometabolic disease (CMD) consists of several modifiable risk factors such as diabetes, obesity and lipids that can lead to a heart attack or stroke and accounts for the majority of deaths in Nor…
PI: Forbes, Nauzer; Heitman, Steven J
Endoscopic retrograde cholangio-pancreatography (ERCP) is a commonly performed procedure to treat conditions of the pancreas and bile ducts. About 50 000 ERCPs are performed in Canada every year, com…
PI: Ahmed, Sofia B
Transgender women (individuals assigned male sex at birth with affirmed woman gender identity), gender-diverse and non-binary individuals may use estrogen in the form of gender-affirming hormone ther…
PI: Thompson, Peter
Type 1 Diabetes (T1D) is a disease that results when the immune system mistakenly destroys most of the insulin-producing beta cells in the body. Insulin is required for our bodies to use energy and d…
Fibrillin-1 is a protein located outside of cells where it forms large fibers termed microfibrils. Genetic mutations in the fibrillin-1 gene cause Marfan syndrome (MFS) and related disorders. Patient…
PI: Shearer, Jane; Scantlebury, Morris
Epilepsy is the most frequent neurologic problem that occurs in childhood. The disease is characterized by a propensity for an individual to have recurrent and unprovoked epileptic seizures. At prese…
PI: Hébert, Marie-Josée; Cardinal, Héloise
Kidneys clean the blood and dispose in the urine of waste produced by all the cells of the body. About 20% of the blood pumped by the heart is filtered by kidneys at a given time. This translates int…
PI: Moore, Sarah A; Ball, Geoff D; Patton, Ian T
We are part of the Obesity Canada team developing the Canadian Clinical Practice Guideline for Managing Pediatric Obesity. Over the last 3 years we have worked together to summarize the best practice…
PI: Mathur, Sunita; Janaudis-Ferreira, Tania
Survival rates have been improving in people with advanced organ disease that undergo solid organ transplantation (SOT). Therefore, there is a need for interventions that enhance long-term health out…
Canada has amongst the highest rates of inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis. Approximately 0.8% of the population has IBD, and this number is expect…
Iron deficiency (ID) is the most common nutritional disorder in the world, and pregnant women and young children are most at risk. The WHO estimates 38% of pregnant women globally have anemia, and mo…
PI: Verdu, Elena F
Inflammatory bowel disease (IBD) is a chronic, relapsing condition that affects the intestinal tract. Canada has one of the highest frequencies of IBD world-wide, imposing a tremendous burden to our …
PI: Forhan, Mary A
More than 8.3 million adults and about 25-30% of Canadian children and youth live with obesity and could benefit from medical support to manage their obesity. Obesity is recognized as a chronic disea…
The 62nd International Conference of the Bioscience of Lipids (ICBL) will be held in-person at the Université du Québec à Montréal (UQAM) from September 4-7th, 2022. The ICBL holds high-quality annua…
PI: Hundemer, Gregory; Akbari, Ayub; Klein, Ran; McCudden, Christopher; Thavorn, Kednapa
Background: Chronic kidney disease (CKD) affects ~5 million Canadians. Not everyone with CKD progresses to kidney failure, but those who do require dialysis or a kidney transplant to survive. Kidney …
PI: McKay, Derek M; Shutt, Timothy E
Canada is a hotspot for inflammatory bowel disease (IBD): chronic conditions of the gut that affect 300,000 Canadians and are increasing in children and adults. Individuals suffering from IBD experie…
Obesity is defined as the excessive accumulation of white adipose tissue and is the most important risk factor for the development of insulin resistance, type 2 diabetes, dyslipidemia, liver diseases…
PI: Sockalingam, Sanjeev; Agic, Branka; Cassin, Stephanie E
Background: Over 60% of Canadians are overweight or obese and more than half have a history of a mental illness. The COVID-19 pandemic has made it difficult for people living with obesity to manage t…
PI: Lam, Tony K
The hallmark feature of obesity-associated type 2 diabetes is elevated blood glucose levels and body weight. The gastrointestinal tract regulates glucose levels, food intake and body weight in rodent…
PI: McGavock, Jonathan M; Baker, Christopher; Smith, Brendan
Type 2 diabetes is a leading cause of death and disability in Canada. To date, the majority of the proposed solutions for reducing the burden of type 2 diabetes in Canada focus on "individualized" in…
PI: Jung, Mary E; Alexander, Amanda; Allen, David P; Casmey, Samantha; Compton, Steve; Cullen, Lon; Hartley-Folz, Samantha; Hughes, Crystal L; Paterson, Kent; Squires, Sherry; Bean, Corliss; Li, Linda C; Mckay, Heather A; Witteman, Holly M
More than 6 million Canadians are at risk for developing type 2 diabetes (T2D). Laboratory-based diabetes prevention programs have not been effective when translated into community settings, mainly d…
PI: Booth, Gillian L; Gebremikael, Liben M; Bacon, Simon L; Ke, Calvin; Lofters, Aisha K; Rainham, Daniel Gareth C
Lifestyle interventions consisting of physical activity and weight loss can prevent or delay the onset of diabetes in people who have earlier stages of disease (known as prediabetes). While these int…
PI: Levin, Adeera; Beaucage, Mary B; Desjarlais, Arlene D; Hillier, David R; McCormick, Michael; Morrin, Louise; Stalker, Leanne; Verdin, Nancy E; Voyageur, Evelyn; Wilson, Mary; Woods, Cathy; Ahmed, Sofia B; Barrett, Brendan J; Battistella, Marisa; Bello, Aminu; Bohm, Clara; Collister, David; Dart, Allison B; Donald, Maoliosa (Mo); Elliott, Meghan; Garg, Amit; Hartwig, Sunny; James, Matthew T; King, Malcolm; Louie, Kelsey; Manns, Braden J; Matsuda-Abedini, Mina; McIntyre, Christopher W; Reich, Heather; Rigatto, Claudio; Sapir-Pichhadze, Ruth; Schick-Makaroff, Kara L; Scholey, James W; Silver, Samuel; Tangri, Navdeep; Tennankore, Karthik K; Thompson, Stephanie; Wicklow, Brandy A; Zappitelli, Michael
Chronic kidney disease (CKD) is a complex condition that affects 1 in 10 Canadians and is estimated to cost Canadian healthcare more than $50 billion each year. Patients with CKD have often been excl…
PI: Budd, Matthew
Type 1 diabetes (T1D) is an incurable, life-long autoimmune disease that affects ~300,000 Canadians. In T1D, the immune system attacks and destroys beta cells in the pancreas that normally produce in…
PI: Lofft, Zoe
Folate is a critical nutrient required for development. Folic acid (FA), the synthetic form of folate, has been fortified into grain products in Canada, which has greatly reduced neural tube defects.…
PI: Shama, Sara
Preterm, very low birth weight (VLBW; birth weight < 1,500 g) infants are born with an immature gastrointestinal tract and a gut bacterial community that is typically perturbed or imbalanced. Encoura…
PI: Prowting, Joel L
Dairy products are important sources of vitamins, minerals, and other beneficial molecules. Human research shows that dairy products can be anti-inflammatory and improve other markers of health. Infl…
If mothers drink alcohol during pregnancy, it can negatively affect the baby and their brain, resulting in fetal alcohol spectrum disorders (FASD). Since the brain runs our learning and memory, if it…
PI: Wong, Helen
Healthy diets are important for the prevention of chronic diseases and the maintenance of health. Retail food environments, like grocery stores, can shape the types of food that we buy and eat. Our f…
The implication of human adipocyte hypertrophy in systemic lipid metabolism and insulin resistance
PI: Ye, Run Zhou
Diabetes is a chronic illness affecting more than 2 million Canadians. There are two types of diabetes: type 1 diabetes and type 2 diabetes. Almost all patients with diabetes have type 2 diabetes. Th…
PI: Marko, Daniel
Many Canadians are overweight or obese and have a higher risk of type 2 diabetes and other metabolic diseases such as fatty liver disease. Sticking to a diet to prevent or reverse obesity and metabol…
In Canada, many children do not consume a healthy diet, increasing their risk of developing obesity and other chronic diseases in both childhood and adulthood. One way to help promote healthier diets…
Au cours des dernières décennies, plusieurs études ont mis en évidence que la consommation régulière de fruits et de légumes est bénéfique pour limiter l'incidence et la progression de maladies hépat…
PI: Côté, Mélina
Selon une étude, plus de la moitié des décès dus aux maladies chroniques sont attribuables aux mauvaises habitudes alimentaires. Au Québec, une étude a récemment démontré que l'alimentation des Québé…
Le système alimentaire mondial actuellement en place, peu favorable à la saine alimentation, a des impacts majeurs sur la santé des individus. En effet, les mauvaises habitudes alimentaires sont le p…
PI: Braun, Jessica L
25% of the Canadian population is considered obese and it's becoming imperative that research find alternative ways to fight off obesity and its associated negative effects. One way to counter obesit…
PI: Alexander, Robert T; Beaucage, Mary B; Burns, Kevin D; Farragher, Janine; Hartwig, Sunny; Ho, Julie; King, Malcolm; Konvalinka, Ana; Levin, Adeera; Madore, François; Pandeya, Sanjay; Schick-Makaroff, Kara L; Stalker, Leanne; Tennankore, Karthik K
The Kidney Research Scientist Core Education and Training (KRESCENT) Program 2.0 will expand and improve the successful original program, a unique, innovative and sustained collaboration between foun…