CIHR Projects
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PI: Schummers, Laura
In Canada, longstanding inadequate and inequitable access to reproductive health services has limited the ability for women to optimally time and space pregnancies - a key reproductive population hea…
PI: Sayani, Ambreen
Lung cancer is the most commonly diagnosed cancer in Canada and is responsible for a quarter of all cancer-related deaths in the country. Screening for lung cancer using tools such as a CT scan can a…
Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer's disease (AD). When combined with ultrasound contrast agents (termed 'microbubbles') th…
PI: Letourneau, Nicole L; Reimer, Jan; Duffett-Leger, Linda A; Graham, Ian D; Moshirpour, Mohammad; Nixon, Kendra L; Parrilla Lopez, Maria Jose; Ross, Kharah M; Stewart-Tufescu, Ashley
Addressing the impact of early childhood adversity (e.g. family violence, parental depression, low-income) can promote children's mental health and development, giving children the best start in life…
PI: Roos, Leslie E; Braun, Mildred J; Archibald, Mandy M; Clement, Fiona Mary; MacKinnon, Anna; Nickel, Nathan C; Tomfohr-Madsen, Lianne M
Untreated parent mental illness often impacts young children by exposing them to stressful events such as violence or unsupportive parent-child relationships. We have created an App-based program cal…
PI: Sadikovic, Bekim
Mitochondrial disorders (MD) are a genetically diverse group of individually rare, but severe human diseases for which no causal treatments are available. The GENOMIT consortium assembles the nationa…
PI: Kao, Dina H
Primary Clostridioides difficile infection (pCDI) is a gastrointestinal infection that presents with diarrhea, fever and abdominal pain and is often resistant to antibiotic therapy. pCDI is often a c…
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PI: Ibarra Moreno, Carlos A; Pawliszyn, Janusz B
Malignant hyperthermia (MH) is a dangerous reaction to certain anesthetics, heat or exercise that can be fatal if left untreated, caused by an inherited dysregulation of calcium inside muscle cells. …
PI: Singh, Karun
Genetic changes affecting the copy number of chromosome 15q13.3 have been linked to a group of rare neurodevelopmental conditions including developmental delay, intellectual disability, autism spectr…
PI: Bolduc, François; Droit, Arnaud
Neurodevelopmental disorders (NDDs) are a major public health problem worldwide, affecting more than 3% of children. These past years, an increasing number of variants in genes encoding proteins of t…
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PI: Lucas, Lynnette J; Bell, Rhonda C; Bill, Lea; Montesanti, Stephanie R; Nepomnaschy, Pablo A; Oster, Richard T; Reading, Jeffrey L; Titone, Sebastien; Venners, Scott; Waddell, Charlotte A; Watts, Jeannette C
The Indigenous Healthy early Life Trajectories Initiative (I-HeLTI) is a novel, community-led partnership focused on strengths-based, multi-generational resilience research. Connecting early life sta…
Canadian ADAptive Platform Trial of COVID-19 Therapeutics in Community Settings (Can-ADAPT COVID)
PI: Pinto, Andrew D; Keynan, Yoav; Greiver, Michelle; Jüni, Peter; Lee, Todd C; McDonald, Emily G; Murthy, Srinivas; Selby, Peter L
While public health measures and vaccines have reduced the spread of SARS-CoV-2, most scientists predict this virus will be endemic and new variants will emerge. Effective and affordable medications …
PI: Masellis, Mario
The pandemic of Coronavirus Disease 2019 (COVID-19) has been implicated in inducing direct and indirect neurological, cognitive, and behavioral effects. Since COVID-19 is manifested as a viral pneumo…
PI: Yee, Amanda
Artificial intelligence (AI) and robotics can advance healthcare and quality of life. The application of these technologies in geriatric medicine, care of older adults, is important as health needs b…