CIHR Projects
Browse 7698 CIHR-funded research projects
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Showing 1-50 of 7698 projects for "cancer"
PI: Sayani, Ambreen
Lung cancer is the most commonly diagnosed cancer in Canada and is responsible for a quarter of all cancer-related deaths in the country. Screening for lung cancer using tools such as a CT scan can a…
PI: Sears, Carly S
Chronic non-cancer pain, encompassing several multifaceted conditions, imposes substantial personal and societal burden worldwide, with yearly costs of approximately $40 billion in Canada alone. Due …
Childhood brain cancer occurs at a critical stage of physical and cognitive development. Although treatments have improved in the past two decades, the severity of the disease and the intensity of th…
PI: Leung, Chelsea
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein 9 (Cas9) is a gene-editing technology that can be used to treat disease. One impactful potential applicati…
PI: Gupta, Keshav
Rhabdomyosarcoma (RMS) is the most common soft-tissue cancer in children and has a particularly poor prognosis with a 5 year survival rate of 30% in individuals with metastatic (spreading throughout …
A Three Dimensional Evaluation of NK cell Prognostic Impact on High Grade Serous Ovarian Cancer
Among all gynecological malignancies high-grade serous carcinoma (HGSC) is the deadliest and most common. It is nicknamed the silent killer because it is detected at later stages and has a poor survi…
PI: Forder, Aisling
Nasopharyngeal carcinoma (NPC) is a cancer that forms in the throat at the level of the nose. The location of the tumour makes it very difficult to detect early, when it is still small, as it does no…
Family caregivers play an important role in the care and support of patients. In fact, they are in a unique position to relieve much of the responsibility from the notoriously burdened medical system…
PI: Trkulja, Kyla L
The nuclear export protein Exportin 1 (XPO1), which carries proteins, ribosomal subunits, and RNA into the cytoplasm, is overexpressed in almost all patients with solid and hematological cancers. Sel…
PI: Feighan, Kira M
Synaptic plasticity, the activity dependent changes in efficacy and strength of synaptic connections in the adult brain, is thought to underlie learning and memory formation. Netrin-1 is a protein th…
PI: Gray, Aidan
The focus of this project is on a type of breast cancer called triple-negative breast cancer (TNBC) that is very aggressive and has a poor prognosis. It affects mainly young women in the prime of lif…
PI: Soliman, Rania
Most patients who have pelvic radiotherapy (RT) as a treatment for cancer experience some degree of acute gastrointestinal (GI) and genitourinary (GU) toxicities. All patients must have access to wel…
PI: Al-Khaz'Aly, Ali
All living cells produce unique vibrations due to internal metabolic processes which have previously been recorded using Atomic Force Microscopy (AFM). These studies have established proof of concept…
Investigating the impact of PGC-1a-coupled metabolic reprogramming on breast cancer metastasis
An increasingly recognized feature of cancer is its ability to make alterations to metabolism to meet the high energy demands of rapidly growing tumours. The ability to reprogram their metabolism als…
PI: Torrens, Aidan
Drug resistance is a major medical challenge leading to low survival rates amongst diseases like lung cancer, the most diagnosed cancer in Canadians. Cisplatin is the current standard of care, but dr…
Cancer mortality rates can be greatly ameliorated by improving early diagnosis mechanisms and routinely screening the population. However, most tumour diagnosis methods are highly invasive and unfeas…
PI: Wang, Nicole I
Invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells are unique subsets of T cells that have been shown to be involved in regulating immune responses to tumors and …
PI: Radadia, Nisarg
Lung cancer is common in Canada. For people diagnosed with early-stage lung cancer, the ideal course of treatment is for the tumor to be surgically removed. However, lung complications are common adv…
PI: Ribeiro, Tiago
Cancer is the leading cause of death in Canada. According to the Canadian Cancer Statistics 2021 report 43% of Canadians will be diagnosed with cancer in their lifetime, one-quarter of which will die…
PI: Wang, Edward
Recent data suggests that stereotactic body radiation therapy (SBRT) may extend progression-free (PFS) and overall survival (OS) of patients with oligometastatic disease (OMD). However, SBRT is not e…
PI: Pain, Rony
Myristoylation is the modification of proteins by a piece of fat named myristate. The two enzymes named NMT1 and NMT2 transfer myristate are found in healthy cells. The Berthiaume lab discovered a pi…
Breast cancer is the most frequently diagnosed cancer in women, and although the 5-year overall survival rate is over 85%, the development of therapy resistance and progression into a metastatic dise…
PI: Lee, Kiera J
Synovial sarcoma is a soft-tissue malignancythat mainly affects adolescents and young adults. Unfortunately, standard chemotherapeutics do not increase survival, creating a need for targeted therapie…
PI: Cuda, Natalie M
Background: Breast cancer survivors (BCS) may experience poor mental health following chemotherapy treatment. The COVID-19 pandemic has exacerbated these symptoms leading to increased levels of anxie…
PI: Tieu, Thuan Minh
Acute lymphoblastic leukemia (ALL) is a serious public health problem in the pediatric population affecting 1 in 1,500 children worldwide, and contributes to 85% of deaths from childhood cancer. It i…
PI: Taal, Dirk B
Oncolytic viruses can be used to target and destroy cancer without harming healthy cells. Clinical trials using an oncolytic reovirus have shown positive results, though the optimization of treatment…
PI: Walker, Richard
Robotic surgery expands the limits of what surgeons can achieve using a minimally invasive approach and is being rapidly adopted in Canada. However, the cost and longer operating times confer signifi…
Epstein-Barr virus (EBV) is a common human herpesvirus that spreads mainly through saliva, often leading to mononucleosis upon initial infection before setting up a lifetime infection. Lifetime infec…
Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer. When it spreads to nearby lymph nodes (LNs), the five-year survival rate halves and the risk for metastasis to distant si…
PI: Hong, Megan M
Immunotherapy is becoming a forerunner in cancer treatment as it enhances the patient's immune system to eliminate cancer cells. Immune checkpoint molecules expressed on T cells regulate the immune s…
PI: Jhajj, Aneet
Approximately 2 in 5 Canadians are expected to be diagnosed with cancer in their lifetime. As cancer incidence rises, advances in early screening and treatment have led to increased overall cancer su…
PI: Xing, Elaine S
The gut microbiota in the gastrointestinal tract is composed of a dense microbial community and makes up the second genetic pool in humans, the microbiome. Notably, the microbiota is necessary for th…
Exploring the use of exosomal plasma gelsolin as a biomarker for early ovarian cancer diagnosis
PI: Gerber, Emma
Ovarian cancer (OVCA) is the most lethal gynecological disease. Unfortunately, less than half of those diagnosed with OVCA will live to see the next 5 years. One of the reasons for this low survival …
PI: Ser, Terri
Adoptive Cell Transfer (ACT) is becoming a popular therapy option for cancer. This treatment involves transferring healthy immune cells into patients to kill cancer cells. Thus far, ACT seems promisi…
Le cancer du sein triple négatif (CSTN) représente 15% des cancers du sein, mais c’est le sous-type de cancer du sein le plus agressif pour lequel aucune thérapie ciblée approuvée n’est disponible. L…
The human colonic microbiome is composed of a diverse range of microorganisms (e.g. bacteria, viruses, fungi) which significantly influence human health and disease. These microbiota collectively pro…
PI: Price, Jared D
Telomeres are regions of repetitive nucleotide sequences located at the end of chromosomes to help preserve the integrity of the genome. These sequences are maintained by Telomerase, a large enzyme c…
PI: Galvin, Claire R
Today, over 80% of children diagnosed with cancer will survive into adulthood. With more and more children surviving, researchers want to focus on improving long-term outcomes as many childhood cance…
PI: Hall, Michael G
Despite recent efforts to improve cancer diagnosis and treatment, the Canadian Cancer Society estimates that cancer will kill 1 in 4 Canadians. A reason for the high proportion of cancer-related deat…
Role of clonal hematopoiesis-associated mutations in neutrophil function and infectious disease
PI: Sadh, Sanathan N
Haematopoetic stem cells (HSCs) which reside in the bone marrow differentiate into various blood cell types including neutrophils and macrophages that are important for first line of defence against …
Lung cancer is the deadliest cancer type in Canada, claiming the lives of 21,000 Canadians every year. Current treatments are damaging not only to cancer cells but also healthy cells. This emphasizes…
PI: Lin, Jeffrey
In 2020, Pancreatic cancer (PC) is the 3rd leading cause of cancer death in Canada, which accounts for 6.4% of total cases. Although the incidence of pancreatic cancer is relatively low compared with…
PI: Hakoum, Mariam
Neuroblastoma (NB) is the second most common pediatric solid tumor cancer of immature nerve cells. NB tumors have a diverse range of clinical behaviors, from spontaneous regression in infants under 2…
Investigating the role of a novel microtubule associating protein in cerebellar morphogenesis
PI: Blommers, Marley
The cerebellum is a structure located at the back of the brain and it regulates the integration and processing of sensory and motor information. Structurally, the cerebellum is relatively simple, com…
PI: Hundal, Anisha
Two major pathways cells use to repair DNA double-strand breaks (DSB) are homologous recombination (HR) and non-homologous end joining (NHEJ). BRCA1 steers cells toward HR and mutations in BRCA1 incr…
Le taux de survie à 5 ans de la leucémie lymphoblastique aiguë (LLA) de l’enfant dépasse maintenant 90%. Cependant, les survivants ont un risque accru de développer des effets secondaires à long term…
Acromegaly is a chronic endocrine condition characterized by excess secretion of growth hormone (GH), most often due to a non-cancerous tumour of the anterior pituitary gland, and subsequent overprod…
PI: Tyrrell, Aidan D
Inflammation is the immune systems response to foreign bodies, where if dysregulated can lead to chronic inflammation playing a major role in numerous diseases including cancer, metabolic syndromes, …
PI: Woo, Stanley
Cancer patients undergoing chemotherapy lose muscle mass. This often occurs concurrently with a pathological deposition of fat into the muscle, a condition known as myosteatosis. Muscle loss and myos…