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Showing 1-50 of 2832 projects for "diabetes"
The Human Milk Oligosaccharide Status in Women With and Without Gestational Diabetes Mellitus
PI: Churchill, Megan
Gestational Diabetes Mellitus (GDM) is a maternal intolerance to glucose (a simple sugar) that can develop during the second to third trimester of pregnancy (20-32 weeks). Human milk (HM) is consider…
Spinal Cord Injury (SCI) is one of the leading causes of disability, and although rehabilitation strategies are common, there is a need for new treatment options that focus on the regeneration of cel…
Cardiorenal benefits of sodium-glucose cotransporter 2 inhibition in type 1 diabetes mellitus
Diabetes mellitus is one of the fastest growing public health crises worldwide and accounts for 6% of global prevalence. Chronic high blood glucose, a hallmark of diabetes, stems from impaired insuli…
PI: Eissa, Azza
The number of Canadians living with diabetes is projected to grow from 10% to 30% by 2030. African, Caribbean and Black (ACB) adults have a 6.6 times higher prevalence of diabetes compared to white a…
Multiple sclerosis (MS) is a progressive inflammatory autoimmune disease and is now increasingly considered to be a metabolic disease. In individuals with MS, the immune system attacks the protective…
PI: Au, Emily
Antipsychotic drugs are often used to treat schizophrenia but these drugs have side effects such as weight gain and increased risk of diabetes and heart disease which may contribute to the shorter li…
Crohns disease (CD) and type 2 diabetes (T2D) are chronic inflammatory diseases characterized by inflammation of the digestive tract and impaired metabolism, respectively. A considerable reduction in…
Elucidating the Cardiovascular Biology of Growth Differentiation Factor 15 in Type 2 Diabetes
PI: Chan, Jordan S
It is now estimated that over 450 million people have diabetes. The majority of these people have type 2 diabetes (T2D), which is the type of diabetes where the body does not respond to the actions o…
As the worldwide population is aging, Canada, particularly New Brunswick, is no exception, with about 1 in 4 individuals above 65 years old. As the population ages, a simultaneous increase in the pre…
PI: Surdi, Julian
Numerous studies have found that exercise training improves glucose handling, insulin sensitivity and prevents type II diabetes, but few have examined whether there are differences in adaptations bet…
Dysfunction of CD8+ T Cell Immunometabolism in Advanced Liver Fibrosis Hepatitis C virus (HCV) infection and non-alcoholic fatty liver disease (NALFD) place a significant burden on individuals and he…
PI: Turner, Lauren V
The number of Canadians living with type 1 diabetes (T1D) continues to rise. T1D is an autoimmune disease where the body does not make insulin, which brings glucose (sugar) out of the blood and into …
PI: Lin, Jeffrey
In 2020, Pancreatic cancer (PC) is the 3rd leading cause of cancer death in Canada, which accounts for 6.4% of total cases. Although the incidence of pancreatic cancer is relatively low compared with…
PI: Chun, Felice I
The prevalence of type 2 diabetes T2D continues to rise, with the International Diabetes Federation estimating 700 million affected individuals by the year 2045. Mirroring the rise of diabetes is the…
The COVID-19 pandemic has resulted in over 250 million cases and over five million deaths worldwide. To combat the global crisis, large-scale vaccination efforts have expedited and redefined the time…
PI: Shi, Qianwen
Skeletal muscle is important for supporting our normal daily activities through maintaining posture and allowing movement. It also helps to regulate blood sugar in our bodies, and when muscles are da…
PI: Thomas, Alaina
Inuit communities in Canada are extraordinarily resilient. Nevertheless, intergenerational trauma stemming from historical and ongoing colonialism continues to impact the mental health of Inuit youth…
Loss of critical heart cells and the associated reduction in heart contraction are defining features of heart dysfunction in aging and after a serious cardiovascular event. Plasminogen activator inhi…
PI: Baerg, Lauren
It is estimated that the population of bacteria that live in our gut, known as the gut microbiota, outnumber the cells of the human body 100 times. The diversity of microbial species and their capabi…
Discriminating Metabolic Health Status in a Cohort of Nursing Students: A Cross-Sectional Study
PI: Lowes, Shanna L
Obesity has become an increasingly problematic health issue worldwide. Obesity is one of the factors that determines an individuals metabolic health, along with blood pressure, blood sugar, and fat l…
Cardiovascular disease (CVD) is the leading cause of death in Canadian women. Weight gain between pregnancies is an essential predictor of a womans lifelong health. By her next pregnancy, a woman is …
Association between fatty acid biomarkers of dairy fat consumption and insulin sensitivity in humans
Greater intake of dairy products has been associated with lower type 2 diabetes(T2D) risk. This inverse association is particularly strong when circulating 15:0, 17:0 and t16:1n-7 fatty acid(FA) leve…
PI: Wu, Olivia
Climate change and chronic disease are global crises linked by a common factor: food. Current food systems contribute to global greenhouse gas emissions and promote nutrient-poor, excessively-caloric…
PI: Chon, Ji-Eun
Obesity is a major global health problem as it poses a significant risk for many chronic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation is a central playe…
Vitamin K is an essential micronutrient known to regulate blood coagulation and bones. Recent clinical observations in humans suggest that partial vitamin K deficiency might be linked to the developm…
PI: Udy, Shannon
Background: Indigenous Peoples in Canada are disproportionately burdened by food insecurity and nutrition-related health problems. Holistic approaches considering all areas of the food system are nee…
Obesity, type 2 diabetes (T2D), and non-alcoholic fatty liver disease are interlinked diseases that have high health and economic burdens. Most research associates intestinal bacteria to T2D and fatt…
PI: Oh, Jean
As the incidence and prevalence of dementia continues to rise, there is a growing need for accessible interventions to manage this devastating condition. Vascular cognitive impairment, primarily caus…
Effects of Resistance Exercise on Blood Glucose in Post-Menopausal Women with Type 1 Diabetes
PI: Logan, Jessica E
Post-menopausal women with type 1 diabetes are at higher risk of heart disease, muscle loss, and bone density loss than women without diabetes, leading to an increased risk of frailty. Existing evide…
PI: Carere, Joseph
Sport related concussion is a common brain injury that happens following a physical force to the head or body. Having a sport related concussion involves short-term disruption in brain function and c…
Having a child with a chronic physical illness (e.g., epilepsy, diabetes) can be detrimental to the mental wellbeing of parents; this can subsequently place children with a physical illness at an inc…
PI: Feng, Jia Nuo
Insulin has saved millions of lives world widely for a century, while GLP-1 as an incretin, stimulates insulin secretion postprandially. GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) including liraglut…
PI: Khouri, Hannah
When deprived of sugar due to starvation, our tissues need an alternative source of energy, so they turn to ketone bodies. Our skeletal muscles are the main location for sugar uptake following a meal…
PI: Wong, Jordan
Introduction: Islet transplantation is an effective way that type 1 diabetic patients can be freed from insulin injections, however the lifelong immunosuppression required to subvert the immune respo…
Bone fractures are among the most commonly occurring musculoskeletal injuries, resulting from a wide variety of causes. From the young and healthy to the aged, bone fractures can occur at any point d…
Our body relies on peptide hormones to control a variety of biological processes involved in growth metabolism. Peptide hormones are first produced as larger proteins (prohormones), which are further…
PI: Osakwe, Adrien
Advances in genetics have increased our understanding of hereditary diseases and their pathologies. New sequencing technology has allowed for the study of different aspects of the human genome, provi…
Type 1 diabetes is an auto-immune disease characterized by the loss of insulin due to the destruction of pancreatic beta cells. Dysregulated production of insulin results in elevated blood glucose le…
Understanding the Connections between IgA-mediated Immunity, the Microbiota & Type I Diabetes
PI: Strachan, Erin
Type 1 Diabetes (T1D) is an autoimmune disease that involves the destruction of insulin-producing cells in the pancreas by autoreactive lymphocytes. Research has shown that abnormalities in the gut p…
I will examine whether brain insulin resistance is involved in the pathophysiology of major depressive disorder (MDD). This research question evolved following the observation that MDD is often co-mo…
Trends in risk factors for diabetes in Canada: migration, temporal, and socioeconomic factors
PI: Chen, Kitty
Knowledge of the diabetes risk factors and their trends has not been developed in Canada, making it difficult to assess the impact of prevention programs on the Canadian population. Differences in th…
PI: Barros, Daniel
Obesity associated type 2 diabetes is characterized by a disruption in glucose homeostasis and energy balance in males and females. Metformin increases glucose tolerance and lowers body weight in rod…
Nobody knows yet why strict blood pressure control (aiming for lower blood pressure levels) prevents heart disease in some people with type 2 diabetes but can have no effect or cause harm in others. …
PI: Patel, Priya
Approximately 30%of Canadian teens are not getting the recommended eight hours of sleep. Certain subgroups are likelier to experience sleep deprivation including girls and Hispanic and Black teens. L…
Northern communities have limited access to fruits and vegetables. This makes it easier to develop health problems. Opaskwayak Cree Nation (OCN) in northern Manitoba near The Pas, has a high rate of …
The prevalence of obesity has tripled since 1975, now affecting over 650 million adults worldwide. Obesity is linked to the development of multiple comorbidities including type 2 diabetes, cardiovasc…
PI: Wood, Madeline
Dementia is a pressing concern given Canadas aging population coupled with the lack of effective treatments for dementia-causing disorders. Vascular risk factors (e.g., diabetes, high cholesterol, hi…
PI: Mahmood, Bushra
Background COVID-19 and pandemic response measures implemented to limit its spread have resulted in various indirect health impacts due to the disruption of many preventative, diagnostic, and managem…
PI: Campbell, David J; Donald, Maoliosa (Mo); James, Matthew T; Manns, Braden J; Pannu, Neesh I; Tsuyuki, Ross T
People with conditions like diabetes, kidney disease, and heart disease take medications that protect them from complications; yet, these same medications may be harmful during times of illness (such…
PI: Chan, John S
High blood sugar and high blood pressure are major risk factors in the development of heart and kidney diseases, including stroke, heart attacks and kidney failure. In the kidney, blood passes throug…