CIHR Projects
Browse 12 CIHR-funded research projects
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PI: Zhang, Dawei
Atherosclerosis is the leading cause of death in Western societies. It is the most important cause of various heart diseases, strokes, myocardial infarctions, and even high blood pressure. Accumulati…
Brain Mechanisms Determining Sympathetic Hyperactivity and Cardiac Dysfunction in Rats Post MI.
PI: Leenen, Frans H
Heart failure is a progressive disease, slowly, but surely disabling the patient. In recent years, it has become clear that besides the initial abnormality in the heart (eg heart attack) increased ac…
PI: Ko, Dennis
Heart disease continues to be the leading cause of morbidity and mortality in Canada. Recently, treatment of heart disease patients has increasingly relied upon minimally invasive procedures such as …
Development of audit with feedback intervention to improve acute cardiovascular care using APPROACH
PI: Sales, Anne E; Ghali, William A; Knudtson, Merril L
In this research project, we are proposing to develop highly effective reports to give health care professionals, including heart specialists, primary care doctors, nurses, and pharmacists, to help t…
PI: Wassmann, Sven
Atherosclerotic diseases such as heart attack and stroke are the leading cause of death in the Western world. We investigate mechanisms that account for pathological changes in the vessel wall which …
A Phase 1, First-in-Man Trial of Intracoronary Collagenase Therapy For Chronic Total Occlusions
Coronary arteries that have been totally blocked for 6 weeks or longer, are called chronic total occlusions (CTO). CTO are found in 30% of all coronary angiograms and frequently cause significant car…
Mechanisms by which Diabetes Mellitus promotes the development and progression of atherosclerosis
Over 75% of people with diabetes will die prematurely of heart attack or stroke. The goal of our research is to; i) determine why, and ii) to find ways to prevent this from happening. We have identif…
Heart malformations present at birth represent the single largest class of birth defects in humans, and are the leading cause of death in infants under one year old. Despite significant advances in o…
PI: Schöck, Frieder
We have identified the LIM domain protein Zasp, which is involved in connecting cells to their environment. This connection is mediated by integrins, proteins that sit in the plasma membrane surround…
PI: Allan, David S
This research addresses the use of blood stem cell products to restore blood flow into damaged tissues. Blood stem cell products used for transplantation include bone marrow, peripheral blood stem ce…
Heart failure (HF) affects 2% Canadians and is now the second leading cause of death. It is therefore important to identify potentially treatable factors that could improve the outcome of this diseas…
Coronary artery disease, leading to chest pain and heart attacks, is the leading cause of death in the developed world. The damaged heart muscle is replaced with scar tissue resulting in diminished a…