CIHR Projects
Browse 12 CIHR-funded research projects
Search & Filter Projects
Showing 1-12 of 12 projects
Genetic and functional analyses of inflammatory caspase functions in inflammation and immunity
PI: Saleh, Maya
Two of the main challenges that multicellular organisms faced during evolution were to cope with invading microorganisms and eliminate and replace dying cells. Our innate immune system evolved to han…
PI: Kane, Kevin P
Natural killer (NK) cells play a vital role in virus infection to slow the spread of virus in the body and production of virus by infected cells, until other components of the immune system can becom…
PI: Lum, Julian J
During an encounter with a foreign pathogen such as a virus or bacterium, the immune system responds by generating a large number of specialized "T cells" to seek and destroy the invading pathogen. W…
PI: Levings, Megan K
The immune system is designed to recognize the difference between harmful and non-harmful foreign proteins, and to not react against proteins that normally exist in an individual. Unfortunately, when…
PI: Baldwin, Troy A
T cells are a type of white blood cell that are critical for providing protection against infections and cancer. T cells mature in an organ called the thymus. It is in the thymus where the ability of…
PI: Yang, Pingchang
As many as 4~8% populations have IgE-mediated hypersensitivity to food antigen. The prevalence of food allergy and related disorders increased rapidly across the world in last few decades. Research i…
PI: Zaph, Colby
An estimated two billion people worldwide are infected with soil-transmitted helminth parasitic worms. Field and experimental studies have shown that immunity in infected individuals is associated wi…
The immune system is critical to human health. In order to develop vaccines and treatments for diseases where the immune system malfunctions (such as immunodeficiency, autoimmunity, allergy and asthm…
PI: Kim, Sung O
Macrophages are key immune cells for detecting and eliminating microbial pathogens. Many pathogens induce macrophage death as a virulence tactic to survive and disseminate within the host. Recent stu…
PI: Rola-Pleszczynski, Marek; Stankova, Jana
Le PAF est une petite molecule bioactive qui attire et active les leucocytes. Il joue un role important dans plusieures maladies inflammatoires et allergiques, telles l'asthme et le choc septique. So…
PI: Collins, Stephen M; Bercik, Premysl
The gastrointestinal (GI) tract and the brain are intimately connected and behavioral factors are important in the expression of common GI diseases such as Irritable Bowel Syndrome (IBS). IBS is the …
This work is to study how a bacterial cell controls the production of a virus-like particle (the gene transfer agent, or GTA) that has the sole function of transfering genes from a donor to a recipie…