CIHR Projects
Browse 20 CIHR-funded research projects
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PI: Brumell, John H
Some bacteria have the remarkable ability to invade our cells and replicate within them during infection. Such bacteria use special toxins to alter the control systems of our cells. These toxins caus…
Microbiologists have traditionally focused on free-floating bacteria growing in laboratory cultures; yet they have recently come to realize that in the natural world more than 99% of all bacteria liv…
PI: Seidah, Nabil G; Labonté, Patrick
This project will focus on studying distinct aspects of the biochemistry, physiology, genetics and clinical applications of two members of a family of human proteases known as PCSK9 and SKI-1 and the…
PI: Moghadas, Seyed M; Pizzi, Nicolino (Nick); Wu, Jianhong
Given the threat of an unprecedented spread of the highly pathogenic avian influenza strain H5N1 in humans, and considering the high degree of morbidity and mortality of previous pandemics, research …
PI: Burrows, Lori L
Pseudomonas aeruginosa is a serious opportunistic and hospital-acquired pathogen, infecting burn, cancer, HIV and cystic fibrosis patients, as well as causing eye, ear and wound infections. It is rap…
Herpesviruses are a large family of pathogens that infect and cause disease in diverse animals ranging from oysters to elephants. My laboratory studies the alphaherpesvirus subgroup that includes the…
PI: Tremblay, CĂ©cile L; Bernard, Nicole F
A certain number of patients, very few, infected with HIV are able to control the virus with no anti-HIV medication. This group of rare patients has been identified as «long term non-progressors» and…
This project focuses on understanding the ways in which deadly fungal pathogens attack people with weakened immune systems. In particular, the project will study the fungal pathogen Cryptococcus neof…
One of the greatest mysteries of Human Immunodeficiency Virus Type 1 (HIV-1) infection has been to understand why the normal immune system is unable to eradicate or control this virus infection as op…
PI: Menzies, Richard
Although effective medications to treat and prevent Tuberculosis (TB) have been available for over 60 years, TB remains the most important infectious cause of mortality among adults in the world. One…
PI: Finlay, Barton B
Enteropathogenic E. coli (EPEC) are a leading cause of bacterial diarrhea, causing much morbidity and mortality in children worldwide. Enterohemorrhagic E. coli (EHEC; E. coli O157) is a close relati…
Hepatitis B virus (HBV) is an important human pathogen implicated in a wide range of clinical manifestations, ranging from cirrhosis, liver cancer and hepatic failure to seemingly asymptomatic and un…
Highly active antiretroviral therapy (HAART) has drastically reduced the morbidity and mortality associated with HIV infection, and transformed HIV from an invariably fatal disease into a manageable,…
Pathogenic E.coli infections are a serious global health concern. During their disease processes, these organisms remain outside of host cells and inject a multitude of pathogenic proteins to command…
Adolescence is a time when children with type 1 diabetes may resist parental involvement in their diabetes management but at the same time, they may neglect aspects of their self-management. Parents …
PI: Kaplan, Gilaad G
Crohn's disease and ulcerative colitis are incurable diseases that affect a patient's gut. The causes of these diseases are not known. However, it most commonly occurs in industrial countries such as…
Mitochondria are extremely dynamic organelles undergoing constant double membrane fusion and fission reactions. The control and mechanisms involved to regulate this activity are currently of great in…
PI: Rathee, Satyapal; Fallone, Biagio G
Nearly half of the cancer patients will receive radiation therapy for their treatment. Image guided radiotherapy promises to precisely align the diseased volume with the radiation beams in real time,…
Cardiovascular disease (CVD) is becoming more common among the First Nations population in Canada, resulting in an increasing burden of illness and death. Hospital admission rates for CVD are stable …
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